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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 39.11899948 23.67700005 Tm 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.89700317 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.8710022 23.67700005 Tm [(Flu)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.82499695 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.79899597 23.67700005 Tm [(555)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 185.75 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 345.86599731 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 376.17999268 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.03700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.41100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.35900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.73300171 12.82499981 Tm [(555)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.32299805 12.82499981 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 202.44799805 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.66000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.03399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98300171 12.82499981 Tm [(555-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.28900146 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.99699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.3710022 12.82499981 Tm [(anti)-1(-mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.83099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.20498657 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.41699219 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150003000400160007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 126 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0019001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(VAlexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.2440033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.61799622 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.56600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.94000244 12.82499981 Tm [(555)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.90499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.27900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 133.42500305 172.3500061 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.29499817 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.69100189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.19100189 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.19799805 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.59100342 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.66299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.16299438 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.88999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.38999939 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.477005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.977005 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.91799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.41799927 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.44299316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.51000023 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00999832 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.10499954 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.60499954 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.16600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.66600037 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1269989 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.60899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.10899353 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.51699829 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.18299866 42.92200089 Tm [(mic)-1(r)1(oorg)1(anis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.59899998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.09900093 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.37599945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.87599945 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.8769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3769989 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.76000214 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.26000214 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.27799988 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.86300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.36300659 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.375 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.52200317 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.0269928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.5269928 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.66799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.16799927 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.14300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.64300537 58.52199936 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(art)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.76399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.26399994 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.1060009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6060009 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.31000137 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81000137 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.84300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.34300232 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.80200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30200195 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.46600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.96600342 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.772995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.272995 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.36799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.86799622 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.08500671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.58499146 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.26699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.76699829 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(wo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 89.72200012 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.19400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.69400024 89.72200012 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.76699829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.26699829 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.34200287 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.84200287 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.28799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.78799438 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.86300659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.36300659 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.36399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.86399841 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.61199951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.11199951 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33399963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.83399963 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.85501099 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.35501099 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 105.3219986 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.14500046 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.64500046 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.92199707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.42199707 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.49700165 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.99700165 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.78399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.28399658 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.44299316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.94299316 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.51899719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.01899719 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.29600525 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.79600525 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.17900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.67900085 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.7539978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.2539978 105.3219986 Tm [(dest)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(oy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.48499966 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.98499966 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.98600006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.48600006 120.92199707 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.33000183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.83000183 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.63700104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.13700104 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.69200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.19200134 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.03399658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.53399658 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.53500366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.03500366 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.13000488 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.63000488 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.21600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.71600342 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.2769928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.7769928 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.92001343 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.42001343 120.92199707 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 136.52200317 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.82099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.32099915 136.52200317 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.21099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.71099854 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.98800659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.48800659 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.48899841 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.98899841 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80499268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.30499268 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.14700317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.64700317 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.51998901 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.46099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.96099854 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.93000031 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.43000031 152.12199402 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.75800323 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.25800323 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.23300171 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.73300171 152.12199402 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26100159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.76100159 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.0490036 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.54899597 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.31300354 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.81300354 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.37399292 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.87399292 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.51899719 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.01899719 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.09399414 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.59399414 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.44799805 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.94799805 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.05899048 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.55899048 152.12199402 Tm [(va)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(riant)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.03800011 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 132.67500305 0.75 l 132.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.67500305 -0.25 l 133.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 133.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 133.42500305 16.35000038 l h f* Q q 1 0 0 1 133.05000305 0 cm -0.625 -0.25 m 290.375 -0.25 l 290.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(50)-1(-)1(2)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90599823 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18399811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.68399811 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.35800171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.85800171 11.72200012 Tm [(ap)1(plic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.62199402 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 0.75 m 133.05000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 133.05000305 173.1000061 m 133.05000305 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07501221 m 423.17498779 189.07501221 l S Q Q q 1 0 0 1 0 463.08401489 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 491.02301025 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 518.9619751 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 546.90100098 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 574.84002686 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 602.7789917 cm Q Q 1 0 0 -1 0 841.90002441 cm
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