%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 86 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 61.20700073 23.67700005 Tm 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.98500061 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.95899963 23.67700005 Tm [(Flu)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.91299438 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.88699341 23.67700005 Tm [(488)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 207.83799744 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.77801514 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 354.0920105 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00080009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.03700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.41100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.35900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.73300171 12.82499981 Tm [(488)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.32299805 12.82499981 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.44799805 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.66000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.03399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98300171 12.82499981 Tm [(488)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.94799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.32200623 12.82499981 Tm [(con)-1(jugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.07400513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.44799805 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.13900757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.51300049 12.82499981 Tm [(Anti-)-1(Chi)-1(ck)1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.7250061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.09899902 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.31100464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000F00100011000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130003000400140006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 126 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98300171 12.82499981 Tm [(488)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.94799805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 135.67500305 172.3500061 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.15299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.65299988 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.3409996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.8409996 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.23699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.73699951 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.2440033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.7440033 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.63699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.13699341 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.20899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.70899963 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.43600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.93600464 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.022995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.522995 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.46400452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.96398926 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.98901367 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.51000023 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00999832 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.10499954 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.60499954 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.16600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.66600037 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1269989 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.60899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.10899353 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.51699829 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.18299866 42.92200089 Tm [(mic)-1(r)1(oorg)1(anis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.59899998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.09900093 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.37599945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.87599945 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.8769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3769989 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.76000214 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.26000214 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.27799988 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.86300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.36300659 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.375 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.52200317 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.0269928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.5269928 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.66799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.16799927 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.14300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.51199913 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.01199913 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.85400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.35400009 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.05799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.55799866 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.59100342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.09100342 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.55000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.05000305 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.21400452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.71400452 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.52099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.02099609 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.11599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.61599731 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.83300781 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.33300781 74.12200165 Tm [(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.84700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.34700012 89.72200012 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.21299744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.71299744 89.72200012 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.78600311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.28600311 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.36100006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.86099243 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.30700684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.80700684 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.88200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.38200378 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.38299561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.88299561 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.6309967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.1309967 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.35299683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.85299683 89.72200012 Tm [(eli)-1(cit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.36400032 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.86399841 105.3219986 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.86100006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.36100006 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.63800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.13800049 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.21299744 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.71299744 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.5 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.15899658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.65899658 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.23500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.73500061 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.01199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.51199341 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.89498901 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.39498901 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.47000122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.30400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.80400085 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.80500031 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.30500031 120.92199707 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.14900208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.64900208 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.45600128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.95600128 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.51100159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.01100159 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.85299683 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.35299683 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.35400391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.85400391 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.94900513 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.44900513 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.03500366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.53500366 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.09599304 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.59599304 120.92199707 Tm [(gene)-1(r)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.2159996 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.7159996 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.22800064 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72800064 136.52200317 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.28500366 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.78500366 136.52200317 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.67500305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.17500305 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.45199585 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.95199585 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.95300293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.45300293 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.26899719 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.76899719 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.61099243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.11099243 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.48400879 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 152.12199402 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.96199989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.46199989 152.12199402 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.34600067 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.84600067 152.12199402 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.1740036 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.6740036 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.64900208 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.14900208 152.12199402 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.67700195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.17700195 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46499634 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96499634 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.72900391 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.22900391 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.78999329 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.28999329 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.93499756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.43499756 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.50999451 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.00999451 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.86401367 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.36401367 152.12199402 Tm [(10)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.51399994 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(10)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(Immunofluoresce)-1(nc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.84100342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.34100342 11.72200012 Tm [(11)-1(00)-1(-)1(1)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.45700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.95700073 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.73500061 11.72200012 Tm [(FCM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.33000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 0.75 m 135.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 173.1000061 m 135.30000305 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07501221 m 423.17498779 189.07501221 l S Q Q q 1 0 0 1 0 463.08401489 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 491.02301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 518.9619751 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 546.90100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 574.84002686 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 602.7789917 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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