%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 79 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [(AlexaFlu)1(or488)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 136.68400574 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 274.71200562 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.02600098 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 310 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -66 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -66 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -13.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -3 61.9640007 Tm [(AlexaFl)-1(uor488)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.82499695 61.9640007 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 126.44999695 61.9640007 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.66200256 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.03599548 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98300171 12.82499981 Tm [(488-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.28900146 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.99699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.3710022 12.82499981 Tm [(anti)-1(-hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.61199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140003000400150007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 126 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Alexa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66100311 12.82499981 Tm [(Fl)-1(uo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98300171 12.82499981 Tm [(488)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.94799805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 216.83399963 m 416.75 216.83399963 l 416.75 248.03399658 l -1.45000005 248.03399658 l h f* Q q 1 0 0 1 0 216.83399963 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 275.97299194 cm q 1 g 0.375 0.75 m 107.92500305 0.75 l 107.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 108.92500305 -0.25 l 108.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 108.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 108.67500305 156.75 l h f* Q q 1 0 0 1 108.30000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.44000244 11.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(erum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.52199936 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.02199936 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.41799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.91799927 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.42500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.92500305 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.81800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.31800079 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.38999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.88999939 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.61700439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.11700439 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.97999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.47999573 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.42100525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.92100525 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.94599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.44599915 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.95599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.45599365 27.3220005 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.55099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.05099487 27.3220005 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.1269989 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.40499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.90499878 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.60900116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.10900116 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.51699829 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.18299866 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.27799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.77799988 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.55499268 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.55599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.05599976 42.92200089 Tm [(molec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ule)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.23099899 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.73099899 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.31600189 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.81600189 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.32800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.82800293 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.97499847 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.47999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.97999573 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.1210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.6210022 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.59599304 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.09599304 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.60800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.10800171 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.94999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.44999695 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.15400696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.65400696 58.52199936 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.68701172 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.18701172 58.52199936 Tm [(im)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mune)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63100052 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13100052 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.29499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.79499817 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.60199738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.10199738 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1969986 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.6969986 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.91400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.41400146 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.09599304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.59599304 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.7769928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.2769928 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.14300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.64300537 74.12200165 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.71600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.21600342 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.29098511 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.79098511 74.12200165 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.27300072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.77300072 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.77399826 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.27399826 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.02200317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.52200317 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.7440033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2440033 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.26499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.76499939 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.76600647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.26600647 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.26300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.76300049 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.03999329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.53999329 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.61500549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11500549 89.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.90200806 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.40200806 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.56100464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.57600021 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.07600021 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.35300064 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.85300064 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.23600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.73600006 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.81099701 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.31099701 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.61500549 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.11500549 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.11599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.61599731 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.46000671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.96000671 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.76699829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.26699829 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.82199097 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.32199097 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.16400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.66400146 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.66500854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.16500854 105.3219986 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.69299984 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.19299984 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.77899933 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.27899933 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.84000015 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.34000015 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.48300171 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.98300171 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.49500275 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.99500275 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.55200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.05200195 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.94200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.44200134 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.71899414 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.21899414 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.22000122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.72000122 120.92199707 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.53601074 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.03601074 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.87799072 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.3730011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.8730011 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.81399918 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.31400299 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.83499908 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.33499908 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.21900177 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.71900177 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.04699707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.54699707 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.52200317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.02200317 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.55000305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05000305 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.33799744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.83799744 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.602005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.102005 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.66299438 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.16299438 136.52200317 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.80801392 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.30801392 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.38299561 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.88299561 136.52200317 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.71699905 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.21699905 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.95300293 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 107.92500305 0.75 l 107.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.92500305 -0.25 l 108.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 108.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.67500305 16.35000038 l h f* Q q 1 0 0 1 108.30000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(1/)-1(10)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(FCM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.83399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.33399963 11.72200012 Tm [(1/)-1(10)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.79499817 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.07299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.57299805 11.72200012 Tm [(Immunofluoresce)-1(nc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.17498779 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.30000305 0.75 m 108.30000305 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.30000305 157.5 m 108.30000305 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q q 1 0 0 1 0 449.82299805 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 477.76199341 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 505.70098877 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 533.64001465 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 561.57897949 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 589.51800537 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>