%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 102 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.39099884 23.67700005 Tm 0 g [(JMJD)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.20399475 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.20399475 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.9079895 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(JMJD7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.45500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.70500183 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.70500183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(JMJD7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.45500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.82900238 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.03099823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.40499878 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.38499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.75900269 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.23300171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ju)-1(m)1(o)-1(nji)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.39199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.76599884 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.16299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.53700256 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.37199402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.7460022 12.82499981 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.06799316 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(128-3)1(07)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(JMJD7)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 395.89099121 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(jumonji)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.44900131 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.94900131 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.77600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.27600098 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.02300262 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.52300262 11.72200012 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.80099487 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P0C8)-1(70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.63800049 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(25)-1(29)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 125.55000305 l 115.47499847 125.55000305 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.06400299 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.56399536 11.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.64100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.14100647 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.44799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.94799805 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.34399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.84399414 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.81900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.31900024 11.72200012 Tm [(JmjC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.73999023 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.23999023 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.76399994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.26399994 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.7820015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.2820015 27.3220005 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.79399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.29399872 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.13600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.63600159 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.63700104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.13700104 27.3220005 Tm [(cu)-1(p)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.88499451 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.38499451 27.3220005 Tm [(metalloenzyme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.14500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.64500427 27.3220005 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.89599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.39599609 27.3220005 Tm [(JmjC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.81698608 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.31698608 27.3220005 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(teins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.56599998 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.06599998 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.23699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.73699951 42.92200089 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.47799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.97799683 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.1190033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.6190033 42.92200089 Tm [(2-oxo)1(glutar)1(ate-Fe\(II\)-dependent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.69500732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.19500732 42.92200089 Tm [(diox)1(y)-1(g)1(e)-1(nase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 58.52199936 Tm [(Most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.86700058 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.36700058 58.52199936 Tm [(tiss)1(u)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.26499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.76499939 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.02200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.52200317 58.52199936 Tm [(express)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.81300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.31300354 58.52199936 Tm [(read-)1(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.37800598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.87800598 58.52199936 Tm [(tr)1(ansc)-1(rip)1(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.96600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.46600342 58.52199936 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.17700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.67700195 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.13299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.63299561 58.52199936 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.12199974 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.1230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.6230011 74.12200165 Tm [(do)1(wnstr)1(e)-1(am)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.22299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.72299957 74.12200165 Tm [(ph)1(osph)1(olipase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.69700623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.19700623 74.12200165 Tm [(A2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.97399902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.47399902 74.12200165 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.68299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.18299866 74.12200165 Tm [(IVB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.56199646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.06199646 74.12200165 Tm [(\(cy)-1(t)1(osolic\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.61599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.11599731 74.12200165 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ne)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.81900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.31900024 89.72200012 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.74599838 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.24599838 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08800125 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58800125 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.68499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.18499756 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.35600281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.85600281 89.72200012 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.60600281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.10600281 89.72200012 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.60099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.10099792 89.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.57400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.07400513 89.72200012 Tm [(combinin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.1289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.6289978 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.63000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.13000488 89.72200012 Tm [(N-t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ermin)-1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.62900162 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.12900162 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.97100067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.47100067 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.92700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.42700195 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.73400116 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.23400116 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.62999725 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.13000488 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.1309967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.6309967 105.3219986 Tm [(ph)1(osph)1(olipase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.60499573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.10499573 105.3219986 Tm [(A2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.88200378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.38200378 105.3219986 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.59100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.09100342 105.3219986 Tm [(IVB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.47000122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.97000122 105.3219986 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.21399975 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 0.75 m 115.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 17.10000038 m 115.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 33.45000076 m 115.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 49.80000305 m 115.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 66.15000153 m 115.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 82.5 m 115.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 98.84999847 m 115.09999847 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.0249939 m 426.92501831 224.0249939 l S Q Q q 1 0 0 1 0 607.5289917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>