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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 73.4980011 23.67700005 Tm 0 g [(JAKMIP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.09700012 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 165.09700012 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 341.80099487 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(JA)1(KMIP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.24700165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.49700165 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.49699402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(JA)1(KMIP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.24700165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.6210022 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.82299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.19700623 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.17700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.55099487 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.0249939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(jan)-1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.68199921 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.05599976 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48999786 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.55299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.92700195 12.82499981 Tm [(microtu)-1(bul)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.06300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.43699646 12.82499981 Tm [(in)-1(te)1(ractin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.6210022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.99499512 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.37701416 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.75100708 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.88198853 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.25601196 12.82499981 Tm [(NECC1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.48901367 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.86300659 12.82499981 Tm [(JA)1(MIP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 348.65499878 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(215)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(JA)1(KMIP2)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 338.10299683 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(janus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.63599968 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.13599968 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.22399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.72399902 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.00099945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.50099945 11.72200012 Tm [(mic)-1(r)1(otubule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.69500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.19500732 11.72200012 Tm [(interacting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.57000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.07000732 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.3769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.8769989 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.15499878 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NECC1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.75 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.25 11.72200012 Tm [(JAMIP)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37000275 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(A)1(A8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.83300018 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(17)-1(35)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.67500305 16.35000038 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 132.67500305 78.75 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(repor)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.83200073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.33200073 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.90699768 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.76100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.26100159 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.23599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.73599243 11.72200012 Tm [(compon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(en)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.00500011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50499916 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84700012 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.84799957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.34799957 27.3220005 Tm [(Go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.30899811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.80899811 27.3220005 Tm [(mat)1(rix.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.6289978 27.3220005 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.62799835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.12799835 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.29899597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.79899597 27.3220005 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.63999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.13999939 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.28100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.78100586 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.7559967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.2559967 27.3220005 Tm [(go)1(l)-1(g)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.82699585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.32699585 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.63400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.13400269 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.64599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.14599609 27.3220005 Tm [(ne)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.71199989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.2120018 42.92200089 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.47799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.97799683 42.92200089 Tm [(tr)1(ansit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.20200348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.70200348 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.54399872 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.04399872 42.92200089 Tm [(sec)-1(reto)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.647995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.147995 42.92200089 Tm [(cargo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.55099487 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.05099487 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.32800293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.82800293 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.33999634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.83999634 42.92200089 Tm [(acting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.3789978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.8789978 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.01998901 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.51998901 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49499512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(st)1(ruc)-1(tura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.72000122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.22000122 58.52199936 Tm [(scaff)1(old)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.98799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.48799896 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.33000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.83000183 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.83100128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.33100128 58.52199936 Tm [(Go)1(l)-1(g)1(i.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.45899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.95899963 58.52199936 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.68200684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.18200684 58.52199936 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.09700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.59700012 58.52199936 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.76599121 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.26599121 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.20700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.37200165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.87200165 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.79399872 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.29399872 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.02999878 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 0.75 m 132.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 17.10000038 m 132.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 33.45000076 m 132.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 49.80000305 m 132.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 66.15000153 m 132.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 82.5 m 132.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 98.84999847 m 132.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 115.19999695 m 132.30000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm
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