%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 78 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.3030014 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 173.15499878 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 203.46899414 23.67700005 Tm 2 Tr [<0007>-4<0008>-4<0009>-4<000A>-4<000B>-4<000C>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 335.99700928 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000E000F00100011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 57.75 12.82499981 Tm [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 102.375 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.58699799 12.82499981 Tm [<000700080009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.58700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.83700562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012000E000F00100011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(anti)-1(-hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.39100647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.76499939 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.977005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.35099792 12.82499981 Tm [(\(Affi)-1(ni)-1(P)1(u)-1(r)1(e\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.36500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00130014001500160011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0017001800190005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001C001D0007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001E000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 113.92500305 156.75 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.68799973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.18799973 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08399963 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.09100342 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48400116 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.05599976 27.3220005 Tm [(9.5)-1(-)1(1)-1(2.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.67199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.17199707 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53500366 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.47599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.97599792 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.00100708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.50100708 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.01098633 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.09500027 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.59499931 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.15600014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.65600014 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.61699677 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.11699677 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.39499664 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.89499664 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.59899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.09899902 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.00700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.50700378 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.67300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.17300415 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.26800537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.76800537 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.04501343 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.54501343 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.54598999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.38299942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.88299942 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.40100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90100098 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.48600006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.98600006 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.4980011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.9980011 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.64500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.14500427 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.6499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.1499939 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.79100037 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.76600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.26600647 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.27799988 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.61999512 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.32400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.82400513 58.52199936 Tm [(ad)1(apt)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.83100033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.33100033 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.79000092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.29000092 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.45400238 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.95400238 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.76100159 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.26100159 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.35600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85600281 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.07299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.57299805 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.25500488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.75500488 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.93600464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.43600464 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.30200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.80200195 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.90800095 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.40800095 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.85400009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.35400009 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.42900085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.92900085 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.93000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.43000031 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1780014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.6780014 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.8999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.3999939 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.42100525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.92100525 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.92199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.42199707 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.41900635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.91900635 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.1960144 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.6960144 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.77099609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.27099609 89.72200012 Tm [(rec)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(uit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29399967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79399967 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.95299911 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.45299911 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.02899933 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.52899933 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.80599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30599976 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.68899536 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.18899536 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.26400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.76400757 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.06799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.56799316 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.56900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.06900024 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.91299438 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.41299438 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.22000122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.72000122 105.3219986 Tm [(var)1(i)-1(a)1(bilit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.1060009 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.6060009 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60699844 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.10699844 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.20199966 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.70199966 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.28800201 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.78800201 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.34899902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.84899902 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.99200439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.49200439 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.0039978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.5039978 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.06100464 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.56100464 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.45098877 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.95098877 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.22799683 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.72799683 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.72900391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.81600189 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.31600189 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.15800095 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.65800095 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.03099823 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.53099823 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.47200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.97200012 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.49299622 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.99299622 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.8769989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.3769989 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.70500183 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.20500183 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.17999268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.67999268 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.20799255 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.70799255 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.9960022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.4960022 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.26000977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.76000977 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.3210144 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.8210144 136.52200317 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(tima)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.37200165 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.87200165 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.9469986 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.4469986 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.30099869 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.8010025 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.91200256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.41200256 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.147995 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 113.92500305 31.95000076 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(00-10)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01699829 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.79499817 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03399658 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.272995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.772995 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.55099487 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92399597 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.19299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.69299316 11.72200012 Tm [(1/)-1(20)-1(0-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.11100006 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.227005 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 0.75 m 113.55000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 157.5 m 113.55000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 429.54501343 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 457.48400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 541.30102539 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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