%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 77 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.69799805 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 170.55000305 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 206.07400513 23.67700005 Tm 2 Tr [<0007>-4<0008>-4<0009>-4<000A>-4<000B>-4<000C>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 338.60198975 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000E000F00100011>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.69000244 12.82499981 Tm [<000700080009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.69000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.94000244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012000E000F00100011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06500244 12.82499981 Tm [(anti)-1(-mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.5249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.89900208 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.46400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.83799744 12.82499981 Tm [(\(Affi)-1(ni)-1(P)1(u)-1(r)1(e\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.852005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00130014001500160011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0017001800190004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001C001D0007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001E000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 119.17500305 0.75 l 119.17500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 120.17500305 -0.25 l 120.17500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.92500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 119.92500305 172.3500061 l h f* Q q 1 0 0 1 119.55000305 0 cm -0.625 -0.25 m 303.875 -0.25 l 303.875 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 11.72200012 Tm [(normally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86199951 11.72200012 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 11.72200012 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42399597 11.72200012 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.48599243 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82800293 11.72200012 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01600647 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 27.3220005 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.95500183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.45500183 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.01599884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.51599884 27.3220005 Tm [(pro)1(min)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.80200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.30200195 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.24299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.74299622 27.3220005 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.41900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.91900635 27.3220005 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.37800598 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.87800598 27.3220005 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.04100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.54100037 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.61599731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.11599731 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.79000854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.29000854 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ntigens)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.86899948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.36899948 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.64599991 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.14599991 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.70700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.20700073 42.92200089 Tm [(larg)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.03500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.53500366 42.92200089 Tm [(confine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.24000549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.74000549 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.81500244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.31500244 42.92200089 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.0059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.5059967 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.91499329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.41499329 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.49000549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.99000549 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.90400696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.40400696 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.07299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.57299805 42.92200089 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Monomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.66699982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.16699982 58.52199936 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.36299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.86299896 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.4240036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.9240036 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.07800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.57800293 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.71899414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.21899414 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.19400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.69400024 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.47799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.97799683 58.52199936 Tm [(bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.29600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.79600525 58.52199936 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.55499268 58.52199936 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.04700089 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54700089 74.12200165 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.40999985 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.90999985 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.7519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.2519989 74.12200165 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.89900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.39900208 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.97499847 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.47499847 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.7519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.2519989 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.39300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.89300537 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.86799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.36799622 74.12200165 Tm [(pentamer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.07200623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.57200623 74.12200165 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.87199402 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.37199402 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.91699219 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.41699219 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.9289856 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.4289856 74.12200165 Tm [(pl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(asma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54800034 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04800034 89.72200012 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79000092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.29000092 89.72200012 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.79799652 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.29799652 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.3730011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.8730011 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.78700256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.28700256 89.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.52200317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.02200317 89.72200012 Tm [(valenc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.04499817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.54499817 89.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.74099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.24099731 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.80200195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.30200195 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.5 89.72200012 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.15499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.65499878 89.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.07000732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.57000732 89.72200012 Tm [(ot)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.08399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.58399963 105.3219986 Tm [(isot)1(y)-1(p)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.00400162 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.50400162 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.06500244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.56500244 105.3219986 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.70899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.20899963 105.3219986 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.05299377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.55299377 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.44900513 105.3219986 Tm [(repeating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.87199402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.37199402 105.3219986 Tm [(epito)1(pe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.71699524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.2170105 105.3219986 Tm [(\(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.48999023 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.98999023 105.3219986 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(art)1(ic)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.34000015 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.84000015 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.11700058 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.61700058 120.92199707 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.91699982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.41699982 120.92199707 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.76000214 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.26000214 120.92199707 Tm [(ce)-1(lls\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84200287 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.34199524 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.6190033 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.1190033 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.67999268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.17999268 120.92199707 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.87800598 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.37800598 120.92199707 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.03300476 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.53300476 120.92199707 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.94799805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.44799805 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.54299927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.04299927 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.98400879 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.48400879 120.92199707 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(tivia)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.89300156 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.39300156 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.39400101 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.89400101 136.52200317 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.25 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.75 136.52200317 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.37800598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.87800598 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.68499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.18499756 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.70100403 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.20100403 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.47900391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.97900391 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.97999573 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.47999573 136.52200317 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.45899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.95901489 136.52200317 Tm [(constan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 152.12199402 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.81499863 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.31499863 152.12199402 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.52999878 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.02999878 152.12199402 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.85399628 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.35399628 152.12199402 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.34700012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.84700012 152.12199402 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.47000122 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.97000122 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.48199463 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.98199463 152.12199402 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.20100403 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.70100403 152.12199402 Tm [(interven)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.61199951 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.11199951 152.12199402 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(eque)-1(nce)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.01399994 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 119.17500305 0.75 l 119.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 120.17500305 -0.25 l 120.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 119.92500305 31.95000076 l h f* Q q 1 0 0 1 119.55000305 0 cm -0.625 -0.25 m 303.875 -0.25 l 303.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.97799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.47799683 11.72200012 Tm [(1/)-1(20)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.43899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.93899536 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.21699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.71699524 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.58999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.08999634 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.35899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.85899353 11.72200012 Tm [(1/)-1(20)-1(-)1(2)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.26501465 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.77799988 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.89399719 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.55000305 0.75 m 119.55000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.55000305 173.1000061 m 119.55000305 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q q 1 0 0 1 0 445.14498901 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 473.08401489 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 501.02301025 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 528.9619751 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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