%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 77 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 145.56700134 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 239.41900635 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.73300171 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 74.73899841 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000700080009000A000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33699799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 108.27799988 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000C00080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.19100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.56500244 12.82499981 Tm [(anti)-1(-Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.61500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.98899841 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.20100403 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 141.81700134 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000E000F0010000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0011001200130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 175.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 126 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 149.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 242.43400574 m 416.75 242.43400574 l 416.75 273.63400269 l -1.45000005 273.63400269 l h f* Q q 1 0 0 1 0 242.43400574 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 301.57299805 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 121.42500305 156.75 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.73400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.23400116 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.63000107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.12999725 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63700104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.13700104 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.02999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.52999878 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.602005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.102005 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.82899475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.32899475 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.41600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.91600037 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.85699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.35699463 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.38198853 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.88198853 27.3220005 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.26199913 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.82300186 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.32300186 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.28399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.78399658 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.06199646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.56199646 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.26599884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.76599884 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.67399597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.17399597 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.33999634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.83999634 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.93499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.43499756 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.71200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.21200562 42.92200089 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.53099823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.03099823 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.5490036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.0490036 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.63400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.13400269 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.64599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.14599609 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.79299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.29299927 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.79800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.29800415 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.43899536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.93899536 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.91400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.41400146 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.92599487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42599487 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.26800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.76800537 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.47198486 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.97198486 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(da)1(ptive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.05799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.55799866 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.01699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.51699829 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.68099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.18099976 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.98800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.48800659 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.58299255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.08299255 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.30000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.80000305 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.48199463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.98199463 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.16299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.66299438 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.5289917 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.0289917 74.12200165 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(unc)-1(t)1(i)-1(o)1(n)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.95299911 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.45299911 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.52799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.02799988 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.47399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.97399902 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.0490036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5490036 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.55000305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.05000305 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.79800415 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.29800415 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.52000427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.02000427 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.04100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.54100037 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.54200745 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.04200745 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.03900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.53900146 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.33200073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.83200073 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61899948 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11899948 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.27799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.77799988 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35399628 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.85399628 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.1309967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.6309967 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.01400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.51400757 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.58900452 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.08900452 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.39300537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.89300537 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.89399719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.39399719 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.23800659 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.73800659 105.3219986 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.70299911 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.20299911 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.04499817 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.54499817 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.54599762 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.04599762 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14099884 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.64099884 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.227005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.727005 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.28799438 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.78799438 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.43099976 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.94299316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.44299316 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.5 120.92199707 Tm [(rec)-1(o)1(mbin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.98999977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.48999977 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.76699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.26699829 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.26800156 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.76799774 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.58399963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.08399963 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9260025 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.4260025 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.79899597 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.29899597 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.24000549 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.74000549 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.26100159 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.76100159 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.64500427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.14500427 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.4730072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.97299194 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.94799805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.44799805 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.97601318 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.28800011 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.78800011 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.55199814 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.05199814 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.61299896 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.11299896 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.75800323 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.25800323 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.33300018 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.83300018 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.68699646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.18699646 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.29800415 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.79800415 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.53399658 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 120.67500305 0.75 l 120.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 121.67500305 -0.25 l 121.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 121.42500305 31.95000076 l h f* Q q 1 0 0 1 121.05000305 0 cm -0.625 -0.25 m 302.375 -0.25 l 302.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.73899841 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.51699829 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2559967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.7559967 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.99499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.49499512 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.772995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.272995 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64599609 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.91499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41500854 11.72200012 Tm [(1/)-1(20)-1(0-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(50)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.11100006 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.227005 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 0.75 m 121.05000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.05000305 157.5 m 121.05000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 491.02301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 518.9619751 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>