%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 77 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 142.96200562 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 236.81399536 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.3380127 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 107.625 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.56400299 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000C00080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06500244 12.82499981 Tm [(Anti-)-1(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.04600525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.41999817 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.98500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000E000F0010000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0011001200130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 111.67500305 156.75 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 11.72200012 Tm [(normally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86199951 11.72200012 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 11.72200012 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42399597 11.72200012 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.48599243 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82800293 11.72200012 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01600647 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.42700195 11.72200012 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.79300022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.29300022 27.3220005 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.55199814 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.05199814 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.61299896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.11299896 27.3220005 Tm [(pro)1(min)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.39900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.89900208 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.83999634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.33999634 27.3220005 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.01600647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.51600647 27.3220005 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.9750061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.4750061 27.3220005 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.63800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13800049 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.21299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.71299744 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.38699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.88699341 27.3220005 Tm [(antig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(en)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.81799984 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.31800079 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.59500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.09500122 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.65599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.15599823 42.92200089 Tm [(larg)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.98400116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.48400116 42.92200089 Tm [(confine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.18900299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.68900299 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.76400757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.26400757 42.92200089 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.95500183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.45500183 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.86399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.36399841 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.43899536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.93899536 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.85299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.35299683 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.02200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.52200317 42.92200089 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.78100586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.28100586 42.92200089 Tm [(Mono)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(meric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.88400078 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.38400078 58.52199936 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.58000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.08000183 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.64099884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.14099884 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.29499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.79499817 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.93599701 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.43599701 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.41100311 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.91099548 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.69500732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.19500732 58.52199936 Tm [(bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.51300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.01300049 58.52199936 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.27200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.77200317 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.04000854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.54000854 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.54098511 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.04098511 58.52199936 Tm [(su)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.15099907 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.65099907 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.49300003 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.99300003 74.12200165 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.63999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.13999939 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.71600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.21600342 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.49299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.99299622 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.13400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.63400269 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.60900116 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.10900116 74.12200165 Tm [(pentamer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.81300354 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.31300354 74.12200165 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.61300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.11300659 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.65800476 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.15800476 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.66999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.16999817 74.12200165 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.86099243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.36099243 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.10299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.50799942 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.00799942 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.08300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.58300018 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.49700165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.99700165 89.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.23200226 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.73200226 89.72200012 Tm [(valenc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.75499725 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25499725 89.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.4509964 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.95100403 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.51199341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.01199341 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.71000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.21000671 89.72200012 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.86500549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.36500549 89.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.77999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.27999878 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.43899536 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.93899536 89.72200012 Tm [(isot)1(y)-1(p)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.35900879 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85900879 89.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.81000137 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.31000137 105.3219986 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.15399933 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65399933 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.05000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55000305 105.3219986 Tm [(repeating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.9730072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.4730072 105.3219986 Tm [(epito)1(pe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.81799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.31799316 105.3219986 Tm [(\(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.59100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.09100342 105.3219986 Tm [(pa)1(rticle)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.1789856 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.6789856 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.95599365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.45599365 105.3219986 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.75601196 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.34300041 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.84300041 120.92199707 Tm [(ce)-1(lls\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.42499924 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.92499924 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.20200348 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.70200348 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.26300049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.76300049 120.92199707 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.46099854 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.96099854 120.92199707 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.61599731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.11599731 120.92199707 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.53100586 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.03100586 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.12600708 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.62600708 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.56700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.06700134 120.92199707 Tm [(activiat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.44700623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.94699097 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.94799805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.44799805 120.92199707 Tm [(comp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(lem)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.94000053 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.43999863 136.52200317 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.06800079 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.56800079 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.375 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.875 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.39099884 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.89099884 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.16900635 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.66900635 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.66999817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.16999817 136.52200317 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.14900208 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64900208 136.52200317 Tm [(constant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.82200623 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.32200623 136.52200317 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.28399658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.78399658 136.52200317 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.99899292 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.49899292 136.52200317 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ur)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.98200035 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.48200035 152.12199402 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.47499847 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.97499847 152.12199402 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.59799957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.09799957 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.61000061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.11000061 152.12199402 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.32899475 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.82899475 152.12199402 Tm [(interven)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.74000549 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.24000549 152.12199402 Tm [(seque)-1(nce)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.41999817 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 111.67500305 31.95000076 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 312.125 -0.25 l 312.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(00-10)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01699829 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.79499817 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03399658 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.272995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.772995 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.55099487 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92399597 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.19299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.69299316 11.72200012 Tm [(1/)-1(20)-1(0-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.11100006 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.227005 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 0.75 m 111.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 157.5 m 111.30000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 429.54501343 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 457.48400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>