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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 145.56700134 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 239.41900635 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.73300171 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 107.625 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.83699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.21099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000C00080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06500244 12.82499981 Tm [(anti)-1(-Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.37399292 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.58599854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000E000F0010000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0011001200130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 100.42500305 156.75 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.44000244 11.72200012 Tm [(ser)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(um)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.97900009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.47900009 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.875 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.375 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.88200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.38200378 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.27500153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.77500153 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.84700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.34700012 27.3220005 Tm [(9.5)-1(-)1(1)-1(2.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.96299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.46299744 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.32600403 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.82600403 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.76699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.26699829 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.29200745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.79199219 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.30200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.80200195 27.3220005 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.89700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.39700317 27.3220005 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.1269989 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.40499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.90499878 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.60900116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.10900116 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.51699829 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.18299866 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.27799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.77799988 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.55499268 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.55599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.05599976 42.92200089 Tm [(molec)-1(ul)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.29000092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.79000092 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.875 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.38700104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.88700104 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.53399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.03399658 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.53900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.03900146 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.17999268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.67999268 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.65499878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.15499878 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.66700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.16700745 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.00900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.50900269 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.21299744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.71299744 58.52199936 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.7460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.2460022 58.52199936 Tm [(immun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.77000046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.27000046 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.07700348 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.57700348 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.67199707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.17199707 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.38900757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.88900757 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.57099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.07099915 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.2519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.7519989 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.61799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.11799622 74.12200165 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.19100952 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.69100952 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.76599121 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.26599121 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.71200562 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.21200562 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.2869873 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.24900055 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.74900055 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.97100067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.47100067 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.49199677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.99299622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.49299622 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.49000549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.99000549 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.26699829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.76699829 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.84199524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.34199524 89.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.1289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.6289978 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.78799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.28799438 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.86401367 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.36401367 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.63999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.13999939 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.21499634 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.71499634 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01899719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51899719 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51999664 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.01999664 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.86399841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.36399841 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.17100525 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.67100525 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.22599792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.72599792 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.56799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.06799316 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.06900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.56900024 105.3219986 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.66400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.16400146 105.3219986 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.75 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.25 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.81100464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.14300156 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.64300156 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.15499878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.65499878 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.21199799 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.71199799 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.602005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.102005 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.3789978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.8789978 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.88000488 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.38000488 120.92199707 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.19599915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.69599915 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.53799438 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.03799438 120.92199707 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.41101074 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.96199989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.46199989 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.34600067 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.84600067 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.1740036 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.6740036 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.64900208 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.14900208 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.67700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.17700195 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46499634 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96499634 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.72900391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.22900391 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.78999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.28999329 136.52200317 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.93499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.43499756 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.50999451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.00999451 136.52200317 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.86401367 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.36401367 136.52200317 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.4750061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.9750061 136.52200317 Tm [(var)1(i)-1(a)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ts)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.68599987 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 99.67500305 0.75 l 99.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 100.67500305 -0.25 l 100.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 100.42500305 31.95000076 l h f* Q q 1 0 0 1 100.05000305 0 cm -0.625 -0.25 m 323.375 -0.25 l 323.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(50)-1(0-200)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.97799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.47799683 11.72200012 Tm [(1/)-1(10)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.16200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.66200256 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.44000244 11.72200012 Tm [(We)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.70500183 11.72200012 Tm [(st)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.31300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.81300354 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.08200073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.58200073 11.72200012 Tm [(1/)-1(10)-1(0-200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.26599121 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.76599121 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.04400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.54400635 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mmunohist)1(oc)-1(h)1(e)-1(mist)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.56500244 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 0.75 m 100.05000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.05000305 157.5 m 100.05000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 429.54501343 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 457.48400879 cm Q Q 1 0 0 -1 0 841.90002441 cm
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