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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 99.22699738 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 148.90299988 23.67700005 Tm 0 Tr [(NHP2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 205.63200378 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 316.07199097 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 65.80999756 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 89.43499756 12.82499981 Tm [(NHP)1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.12599945 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.62600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.87600708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(HP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.7990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.17299652 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.82299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.19700623 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.7559967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.13000488 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.92599487 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(NHP)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.06600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.44000244 12.82499981 Tm [(rib)-1(onu)-1(c)1(l)-1(eoprotein)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.3999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.77400208 12.82499981 Tm [(DKCB2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.13000488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.5039978 12.82499981 Tm [(NHP)1(2P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.80400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.17799377 12.82499981 Tm [(NOLA2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.72000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(NHP)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.06600189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019001A001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D001E001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001F0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 24.53299904 m 42 24.53299904 l 42 42.54399872 l 0 42.54399872 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 38.11399841 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 42 38.11399841 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 152.92500305 0.75 l 152.92500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 153.92500305 -0.25 l 153.92500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 153.67500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 153.67500305 203.55000305 l h f* Q q 1 0 0 1 153.30000305 0 cm -0.625 -0.25 m 270.125 -0.25 l 270.125 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(H/)-1(A)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.41299438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.91299438 11.72200012 Tm [(snoRNP)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.21099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.71099854 11.72200012 Tm [(\(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.08099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.58099365 11.72200012 Tm [(nu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cl)-1(eolar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.04199982 27.3220005 Tm [(ribo)1(n)-1(ucle)-1(o)1(prot)1(e)-1(ins\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.65000153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15000153 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.66600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.16600037 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.41400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.91400146 27.3220005 Tm [(snoRNP)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.21200562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.71200562 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.22999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.72999573 27.3220005 Tm [(invo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.98200035 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.48200035 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.42300034 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.92300034 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.88700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.38700104 42.92200089 Tm [(asp)1(e)-1(cts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.41400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.91400146 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.7559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.2559967 42.92200089 Tm [(rRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.21699524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.71699524 42.92200089 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.272995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.772995 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.05000305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.55000305 42.92200089 Tm [(mod)1(i)-1(f)1(ic)-1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.43999863 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.93999863 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.28699875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.78699875 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.29399872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.79399872 58.52199936 Tm [(cl)-1(a)1(ssified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.78199768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.28199768 58.52199936 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.29800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.79800415 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.97900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.47900391 58.52199936 Tm [(fa)1(mi)-1(lies:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.6309967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.1309967 58.52199936 Tm [(C/D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.852005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.352005 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.6289978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(H/)-1(A)1(CA.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.65800095 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.15800095 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.96500015 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.46500015 74.12200165 Tm [(H/)-1(A)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.95700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.45700073 74.12200165 Tm [(snoRNP)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.75500488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.25500488 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.51199341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.01199341 74.12200165 Tm [(inc)-1(lude)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.27000427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.77000427 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.77099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.27099609 74.12200165 Tm [(DK)1(C1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.30400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.80400085 74.12200165 Tm [(NOL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(A1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.60999966 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.11000061 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.38700104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.88700104 89.72200012 Tm [(NOLA3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.76699829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.26699829 89.72200012 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.90599823 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.40599823 89.72200012 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.48599243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.98599243 89.72200012 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.80999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.30999756 89.72200012 Tm [(H/)-1(A)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.80200195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.30200195 89.72200012 Tm [(snoRNP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.43400574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.93400574 89.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 105.3219986 Tm [(localize)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.63899994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.13899994 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.21399689 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.71399689 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.71499634 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.21499634 105.3219986 Tm [(dense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.89700317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.39700317 105.3219986 Tm [(fib)1(ril)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.69299316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.19299316 105.3219986 Tm [(components)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.04800415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.54800415 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.38999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.88999939 105.3219986 Tm [(nuc)-1(leoli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.50799561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.85199928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.35200119 120.92199707 Tm [(coile)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.24000168 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.73999786 120.92199707 Tm [(\(Caja)1(l)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.51999664 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.01999664 120.92199707 Tm [(bo)1(die)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.91400146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.41400146 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.35499573 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.85499573 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.85600281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.35600281 120.92199707 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.34100342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.84100342 120.92199707 Tm [(Both)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.10400391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.60400391 120.92199707 Tm [(18)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.35400391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.85400391 120.92199707 Tm [(rRN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 136.52200317 Tm [(pro)1(duc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.57099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.07099915 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.34799957 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.84799957 136.52200317 Tm [(rRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.80899811 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.30899811 136.52200317 Tm [(pseudourid)1(y)-1(la)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.63699341 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.13699341 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.65499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.15499878 136.52200317 Tm [(impair)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.40100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.90100098 136.52200317 Tm [(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41598511 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(any)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.2840004 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.7840004 152.12199402 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.15800095 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.65800095 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.5 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.00099945 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.50099945 152.12199402 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.32499695 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.82499695 152.12199402 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.29800415 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.79800415 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.35899353 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.85899353 152.12199402 Tm [(depleted.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.35499573 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.85499573 152.12199402 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.66200256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16200256 152.12199402 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.98599243 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.48599243 152.12199402 Tm [(H/)-1(A)1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 167.72200012 Tm [(snoRNP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.96500015 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.46500015 167.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.93800354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.43800354 167.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.95600128 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.45600128 167.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.71299744 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.21299744 167.72200012 Tm [(components)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.06799316 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.56799316 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.41000366 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.91000366 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.91099548 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.41099548 167.72200012 Tm [(telomera)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 183.32200623 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.41799927 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.91799927 183.32200623 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18000031 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68000031 183.32200623 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.19599915 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.69599915 183.32200623 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.61300659 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.11300659 183.32200623 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.08799744 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.58799744 183.32200623 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89500427 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.39500427 183.32200623 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.52400208 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.02400208 183.32200623 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.09899902 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.59899902 183.32200623 Tm [(Sacc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(ha)1(romyc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.6570015 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.1570015 198.92199707 Tm [(ce)-1(revisiae)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08100128 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.58100128 198.92199707 Tm [(Nhp)1(2)-1(p)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.38000488 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.88000488 198.92199707 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.60299683 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.10299683 198.92199707 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.01800537 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.51800537 198.92199707 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.68699646 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.18699646 198.92199707 Tm [(i)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.30000305 0.75 m 153.30000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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6 0 obj
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