%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 159 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.0739975 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.75 23.67700005 Tm 0 Tr [(NHE)1(J1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 208.78500366 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 22 Tf 1 0 0 -1 319.2250061 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(NHEJ1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.36599731 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.86599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.11599731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(HEJ1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.22399902 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.87399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.2480011 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.80700684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.18099976 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.977005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XLF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.68900299 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NHEJ1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.11599731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0013000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001A000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.80000305 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.49099731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B001C001D0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001E0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001D0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 143.17500305 109.94999695 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.49900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.99900055 11.72200012 Tm [(breaks)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.33100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.83100128 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.27200317 11.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.2769928 11.72200012 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.27999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.77999878 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.49099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.99099731 11.72200012 Tm [(genoto)1(xic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.16600037 11.72200012 Tm [(st)1(re)-1(ss)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.83300781 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.29499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.79499817 27.3220005 Tm [(amo)1(n)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.22699738 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.72699738 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.72799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.22799683 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.90200043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.40200043 27.3220005 Tm [(da)1(maging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.4960022 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.33799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.83799744 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.34300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.84300232 27.3220005 Tm [(lesi)-1(o)1(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.5059967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.0059967 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.26800537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.76800537 27.3220005 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(en)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75899982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.25900078 42.92200089 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.17599869 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.67599869 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.65100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.15100098 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.65599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.15599823 42.92200089 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.25299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.75299835 42.92200089 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.87199402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.37199402 42.92200089 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.58000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.08000183 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.35800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.85800171 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.85899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.35899353 42.92200089 Tm [(nonhom)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(olog)1(ous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.02899933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.52899933 58.52199936 Tm [(en)-1(d)1(-joining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.59600067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.09600067 58.52199936 Tm [(pa)1(thw)1(ay,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.72399902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.22399902 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.32099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.82099915 58.52199936 Tm [(preferentially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.70399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.20399475 58.52199936 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.4960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.09700012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.59700012 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.43899918 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.93899918 74.12200165 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.20300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.70300293 74.12200165 Tm [(breaks.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.20100403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.70100403 74.12200165 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.55000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.05000305 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.99099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.49099731 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.94700623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.44700623 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.9630127 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.4630127 74.12200165 Tm [(ca)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(use)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.81799984 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.31800079 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.25799942 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.75799942 89.72200012 Tm [(ki)-1(nd)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.52200317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.02200317 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.86399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36399841 89.72200012 Tm [(seve)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.00999451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.50999451 89.72200012 Tm [(combine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.72999573 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.22999573 89.72200012 Tm [(immun)-1(o)1(defic)-1(ienc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.52099609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.02099609 89.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(isord)1(e)-1(r)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.35200119 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NHEJ1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.06800079 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(NHEJ1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.93099976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(non-ho)1(mologo)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.43199921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.93199921 11.72200012 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.34100342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.84100342 11.72200012 Tm [(joining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.10499573 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.22399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.72399902 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.0019989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 110.69999695 m 142.80000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 127.04999542 m 142.80000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 143.3999939 m 142.80000305 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 159.75 m 142.80000305 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.7250061 m 423.17498779 175.7250061 l S Q Q Q 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