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12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(GEF)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 107.08699799 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 109.46099854 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 135.11099243 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 137.48500061 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 181.04400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 183.41799927 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 221.21400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(neuron)-1(al)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 101.41100311 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 103.78500366 12.82499981 Tm [(guani)-1(ne)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 137.94099426 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 140.31500244 12.82499981 Tm [(nu)-1(cleotid)-1(e)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 185.6269989 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 188.00100708 12.82499981 Tm [(exchange)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 228.44200134 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 230.81599426 12.82499981 Tm [(factor;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 259.01400757 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 261.38800049 12.82499981 Tm [(EPHEXIN;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 301.29098511 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 303.66500854 12.82499981 Tm [(ARHG)1(E)-1(F27)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 349.20300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000F>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NG)1(E)-1(F)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 86.35299683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019001A001B001C>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<001E>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000E>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 91 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700220024>] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 98 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 99 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 101 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 12.89099979 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 103 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 149.92500305 141.1499939 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 104 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Acts)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 18.36499977 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 22.86499977 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 32.00600052 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 36.50600052 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 41.48099899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 45.98099899 11.72200012 Tm [(guanine)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 80.85199738 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 85.35199738 11.72200012 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 130.79100037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 135.29100037 11.72200012 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 176.39700317 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 180.89700317 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 206.01600647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 210.51600647 11.72200012 Tm [(\(GE)1(F)-1(\))] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 232.94999695 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 237.44999695 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 262.54699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(ll)-1(y)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 53.86399841 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 58.36399841 27.3220005 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 95.9240036 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 100.4240036 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 114.42500305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 118.92500305 27.3220005 Tm [(GTPa)1(se)-1(s)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 154.69599915 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 159.19599915 27.3220005 Tm [(RHOA,)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 187.86599731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 192.36599731 27.3220005 Tm [(RA)1(C1)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 215.87199402 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 220.37199402 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 236.64900208 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 241.14900208 27.3220005 Tm [(CDC4)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(2.)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 7.44399977 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 11.94400024 42.92200089 Tm [(Plays)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 33.75 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 38.25 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 43.22499847 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 47.72499847 42.92200089 Tm [(role)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 64.38500214 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 68.88500214 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 76.8259964 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 81.3259964 42.92200089 Tm [(axo)1(n)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 102.12999725 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 106.62999725 42.92200089 Tm [(guida)1(n)-1(ce)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 146.2250061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 150.7250061 42.92200089 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 194.99099731 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 199.49099731 42.92200089 Tm [(ephrin-induce)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 41.17300034 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 45.67300034 58.52199936 Tm [(cone)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 66.55999756 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 71.05999756 58.52199936 Tm [(collapse)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 106.08000183 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 110.58000183 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 126.85700226 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 131.35699463 58.52199936 Tm [(dendrit)1(i)-1(c)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 169.61599731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 174.11599731 58.52199936 Tm [(spine)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 197.07699585 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 201.57699585 58.52199936 Tm [(morp)1(hog)1(e)-1(nesi)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s.)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 6.33300018 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 10.83300018 74.12200165 Tm [(Up)1(on)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 34.56800079 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 39.06800079 74.12200165 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 81.01799774 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 85.51799774 74.12200165 Tm [(by)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 96.02999878 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 100.52999878 74.12200165 Tm [(ephrin)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 128.30299377 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 132.80299377 74.12200165 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 167.69999695 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 172.19999695 74.12200165 Tm [(EPHA4,)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 203.39199829 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 207.89199829 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 221.89300537 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 226.39300537 74.12200165 Tm [(GE)1(F)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 242.81500244 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 247.31500244 74.12200165 Tm [(acti)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(vity)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 15.23600006 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 19.73600006 89.72200012 Tm [(sw)1(i)-1(t)1(c)-1(h)1(e)-1(s)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 56.08300018 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 60.58300018 89.72200012 Tm [(to)1(war)1(d)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 90.93199921 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 95.43199921 89.72200012 Tm [(RHOA)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 121.93499756 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 126.43499756 89.72200012 Tm [(resulting)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 164.13600159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 168.63600159 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 176.57699585 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 181.07699585 89.72200012 Tm [(its)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 190.99099731 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 195.49099731 89.72200012 Tm [(activat)1(ion.)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 239.60800171 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 244.10800171 89.72200012 Tm [(Activ)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(at)1(e)-1(d)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 19.19099998 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 23.69099998 105.3219986 Tm [(RHOA)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 50.19400024 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 54.69400024 105.3219986 Tm [(pro)1(motes)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 96.3809967 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 100.8809967 105.3219986 Tm [(cone)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 121.76799774 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 126.26799774 105.3219986 Tm [(retra)1(c)-1(t)1(ion)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 168.10400391 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 172.60400391 105.3219986 Tm [(at)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 180.93200684 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 185.43200684 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 199.43299866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 203.93299866 105.3219986 Tm [(expense)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 239.27400208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 243.77400208 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 252.61599731 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 257.11599731 105.3219986 Tm [(R)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(AC1-)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 21.52400017 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 26.02400017 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 42.30099869 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 46.80099869 120.92199707 Tm [(CDC42-stimulat)1(e)-1(d)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 125.62599945 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 130.12600708 120.92199707 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 161.04200745 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 165.54200745 120.92199707 Tm [(cone)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 186.42900085 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 190.92900085 120.92199707 Tm [(extension)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 232.43099976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 236.93099976 120.92199707 Tm [(\(By)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 250.3480072 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 254.8480072 120.92199707 Tm [(si)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(milarit)1(y)-1(\).)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 37.31800079 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 241 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 242 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 243 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 249 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 254 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 255 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NGE)1(F)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 23.73900032 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 0.75 m 149.55000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 141.8999939 m 149.55000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 158.25 m 149.55000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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