%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.17500305 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 141.85099792 23.67700005 Tm 0 Tr [(NFKB)1(IZ)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 212.68499756 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.125 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(NFKB)1(IZ)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 109.08100128 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 161.58099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.08099365 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BIZ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.06400299 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.43800354 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.08799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46200562 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.02099609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.39500427 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.19099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IK)1(BZ)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.53800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.91200256 12.82499981 Tm [(IN)1(AP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.64499664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.01899719 12.82499981 Tm [(MAIL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.13200378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)1(IZ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.33100128 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 148.42500305 172.3500061 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 275.375 -0.25 l 275.375 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(anky)-1(rin-)1(re)-1(p)1(e)-1(a)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.10099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.60099792 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.68299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.18299866 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.46000671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.95999146 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52099609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.61999893 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.11999893 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.63199997 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.13199997 27.3220005 Tm [(lipop)1(olysac)-1(cha)1(ride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.397995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.897995 27.3220005 Tm [(\(LPS\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.39599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.89599609 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.70300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.20300293 27.3220005 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.75700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.25700378 27.3220005 Tm [(po)1(rtio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.88800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.38800049 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.38899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.88899994 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.39600372 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.89600372 42.92200089 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.97100067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.47100067 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.56799316 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.06799316 42.92200089 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.28300476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.78300476 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.78399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.28399658 42.92200089 Tm [(anky)-1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.84599304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.34599304 42.92200089 Tm [(repe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.65999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.15999985 58.52199936 Tm [(sha)1(re)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.55099869 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.05099869 58.52199936 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.28600311 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.78600311 58.52199936 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.63300323 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.13300323 58.52199936 Tm [(similarit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.83999634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.33999634 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.73599243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.23599243 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.23699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.73699951 58.52199936 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.38299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.88299561 58.52199936 Tm [(kappa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.22799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.72799683 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.875 58.52199936 Tm [(fa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.98699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.48699951 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.32900047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.82899857 74.12200165 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.46800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.96800232 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.77500153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.27500153 74.12200165 Tm [(lat)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.89399719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.39399719 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.91200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.41200256 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.23100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.73100281 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.80599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.30599976 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.18699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.68699646 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.66200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.16200256 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.82200623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.32200623 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.76300049 74.12200165 Tm [(inf)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(lammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.48500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.98500061 89.72200012 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14800262 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.64800262 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.72299957 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.22299957 89.72200012 Tm [(LPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.54199982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.04200745 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.55400085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.05400085 89.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.88699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.38699341 89.72200012 Tm [(interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.727005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.227005 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.6230011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.1230011 89.72200012 Tm [(NF-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.76199341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.47299957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.97299957 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.87000275 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.37000275 105.3219986 Tm [(anky)-1(rin-)1(re)-1(p)1(e)-1(a)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.55000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.05000305 105.3219986 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.21000671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.71000671 105.3219986 Tm [(Studies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.22799683 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.72799683 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.66900635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.16900635 105.3219986 Tm [(mous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(indic)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.64599991 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.14599991 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.36799622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.86799622 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.3239975 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8239975 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33999634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.83999634 120.92199707 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.91499329 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.41499329 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.97599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.47599792 120.92199707 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8500061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.3500061 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.19200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.69200134 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.69299316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.19299316 120.92199707 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.71099854 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.21099854 120.92199707 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.85699463 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.35699463 120.92199707 Tm [(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ap)1(pa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.44499969 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.94499969 136.52200317 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.59199905 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.09199905 136.52200317 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.56500244 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.06500244 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.34200287 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.84200287 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.36299896 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.86299896 136.52200317 Tm [(activat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.30900574 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80900574 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.65100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.15100098 136.52200317 Tm [(IL-6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.58700562 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.08700562 136.52200317 Tm [(pro)1(duc)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.99099731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.49099731 136.52200317 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.47799683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.92200089 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.42200089 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.99199677 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.49199677 152.12199402 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.83399963 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.33399963 152.12199402 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.27400208 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.77400208 152.12199402 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93400574 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.43400574 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.78100586 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.28100586 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.78799438 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.28799438 152.12199402 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ound)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.56999969 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06999969 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.34799957 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.84799957 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.30400085 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.80400085 167.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.48600006 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 0.75 m 148.05000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>