%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 146 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 16.53300095 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 66.20899963 23.67700005 Tm 0 Tr [(NFKB)1(IE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.75799561 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73199463 23.67700005 Tm [(\(Ph)1(osph)1(o-Ser22\))] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 288.32598877 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 398.76599121 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(NFKB)1(IE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.16600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.54000092 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser2)1(2\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 190.63000488 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 243.13000488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.88000488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BIE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.27500153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.64900208 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser2)1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.73899841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.11300659 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.76300049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.13699341 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.6960144 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.07000732 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.86599731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IK)1(BE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.93900299 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)1(IE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.54100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.91500092 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser2)1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.00500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 144.67500305 94.34999847 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.71699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.21699524 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.29200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.79200745 11.72200012 Tm [(components)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.64700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.14700317 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.98901367 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(NF-kapp)1(a-B,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.04399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.54399872 27.3220005 Tm [(tr)1(app)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.5019989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.0019989 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.00299835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.50299835 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.98199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.48199463 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.42300415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.92300415 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92399597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.42399597 27.3220005 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.49200439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.99200439 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.26899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.76901245 27.3220005 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(eve)-1(nt)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.5340004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.0340004 42.92200089 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.7820015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.2820015 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.49299622 42.92200089 Tm [(activat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.47799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.97799683 42.92200089 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.66000366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.16000366 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.10099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.60099792 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.602005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.102005 42.92200089 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.08700562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.58700562 42.92200089 Tm [(Pho)1(spho)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(lat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.38500023 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.88500023 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.72700119 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.22700119 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.22800064 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.72800064 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.23500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.73500061 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.04200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.54200745 58.52199936 Tm [(ta)1(rgets)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.68800354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.18800354 58.52199936 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.93600464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.43600464 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.21400452 58.52199936 Tm [(dest)1(ru)-1(ctio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.10800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.60800171 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.11999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 74.12200165 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.18199921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.68199921 74.12200165 Tm [(pa)1(thw)1(ay,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.30999756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.80999756 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.90699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.40699768 74.12200165 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.96699524 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.46699524 74.12200165 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.34399414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.84399414 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.35600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.85600281 74.12200165 Tm [(maki)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 89.72200012 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.5510006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.0510006 89.72200012 Tm [(ava)1(il)-1(a)1(ble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.73899841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.23899841 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.31400299 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.81400299 89.72200012 Tm [(tr)1(ansloc)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35400391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.85400391 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.92900085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.42900085 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.42999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.92999268 89.72200012 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.91499329 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFKBIE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.05200005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.55199814 11.72200012 Tm [(\(Pho)1(spho)1(-Ser2)-1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.6969986 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.67500305 16.35000038 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(NFKBIE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.91499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.41499329 11.72200012 Tm [(\(Pho)1(spho)1(-Ser2)-1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.55999756 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 144.67500305 31.95000076 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.51799965 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01800156 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.13700104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.63700104 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.47899628 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.97899628 11.72200012 Tm [(kappa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.3239975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.8239975 11.72200012 Tm [(light)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.76499939 11.72200012 Tm [(po)1(l)-1(yp)1(e)-1(pt)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.60699463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.10699463 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.6230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.1230011 11.72200012 Tm [(en)-1(h)1(anc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.89399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.39401245 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.33499146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(B-c)-1(ells)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.11599922 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.61600113 27.3220005 Tm [(inhibito)1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.31400299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.81400299 27.3220005 Tm [(epsilon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.89199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.39199829 27.3220005 Tm [(\(Pho)1(spho)1(-Ser2)-1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.53700256 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.34999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 0.75 m 144.30000305 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 95.09999847 m 144.30000305 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 111.44999695 m 144.30000305 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 127.79999542 m 144.30000305 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 144.1499939 m 144.30000305 175.34999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.34999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.72499084 m 423.17498779 175.72499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>