%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 157 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.49900055 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 140.17500305 23.67700005 Tm 0 Tr [(NFKB)1(ID)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.36099243 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 324.80099487 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(NFKB)1(ID)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 121.12400055 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.62399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.98200226 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.63200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.0059967 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.56500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93899536 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.73500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TA-NFKBH,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.33699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.71099854 12.82499981 Tm [(IkappaBNS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.53599548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)1(ID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.87400055 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 24.53299904 m 42 24.53299904 l 42 42.54399872 l 0 42.54399872 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 38.11399841 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 38.11399841 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 155.17500305 203.55000305 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.53199959 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.03199959 11.72200012 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.70700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.20700073 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.20800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.70800018 11.72200012 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.66200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.16200256 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.0039978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.5039978 11.72200012 Tm [(IL-2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.60600281 11.72200012 Tm [(IL-6,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.20799255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.70799255 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.98500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.48500061 11.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.64399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.14399719 11.72200012 Tm [(cy)-1(t)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ki)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.11300087 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.61300087 27.3220005 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.50999832 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.01000214 27.3220005 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.24099731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.74099731 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.00900269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.50900269 27.3220005 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.38600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.88600159 27.3220005 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.52400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.02400208 27.3220005 Tm [(Fun)-1(ctio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.15299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.65299988 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.65399933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.15399933 42.92200089 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.38500214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.88500214 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.72699738 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.22699738 42.92200089 Tm [(inflammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.772995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.272995 42.92200089 Tm [(responses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.60299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.10299683 42.92200089 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.63499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13499451 42.92200089 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.39199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.67499924 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.17499924 58.52199936 Tm [(TCR-induce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.7440033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2440033 58.52199936 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.20599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.70599365 58.52199936 Tm [(sele)-1(ction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.00900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.50900269 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.35099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.85099792 58.52199936 Tm [(th)1(y)-1(mo)1(c)-1(ytes.I)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 252.37800598 58.52199936 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 74.12200165 Tm [(BNS)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.32500076 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.82500076 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.82600021 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.32600021 74.12200165 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.84400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.34400177 74.12200165 Tm [(I)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 81.98999786 74.12200165 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.13600159 74.12200165 Tm [(B-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.47299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.97299957 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77999878 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.28700256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.78700256 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.29899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79899597 74.12200165 Tm [(Nfkbid,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.20199585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.70199585 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.76300049 74.12200165 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(equire)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.10400009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.60400009 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.88199997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.38199997 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.38300323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.88300323 89.72200012 Tm [(development)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.88000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.38000488 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.22200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.72200012 89.72200012 Tm [(marg)1(in)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.63400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.13400269 89.72200012 Tm [(zo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.93299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.43299866 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.71000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.21000671 89.72200012 Tm [(perit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(oneal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.74399948 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24399948 105.3219986 Tm [(B-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.06200027 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.56200027 105.3219986 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.20899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.70899963 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.28500366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.78500366 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.06199646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.56199646 105.3219986 Tm [(ad)1(ditionally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.98899841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.48899841 105.3219986 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.02999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.52999878 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.80799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.30799866 105.3219986 Tm [(extra)1(follic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.35199928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.85199928 120.92199707 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.11100006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.61100006 120.92199707 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.77400208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.27400208 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.34899902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.84899902 120.92199707 Tm [(T-independe)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.8690033 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.3690033 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.64599609 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.14599609 120.92199707 Tm [(-d)1(e)-1(p)1(e)-1(nde)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 136.52200317 Tm [(immun)-1(o)1(gen)-1(s)1(.I)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 74.86100006 136.52200317 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 80.00700378 136.52200317 Tm [(BNS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.16500092 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.66500092 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.34700012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.84700012 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.35400391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.85400391 136.52200317 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.78500366 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.28500366 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.42599487 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.92599487 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.90100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.40100098 136.52200317 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.66499329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 152.12199402 Tm [(I)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 34.48899841 152.12199402 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 39.63499832 152.12199402 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.2820015 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.7820015 152.12199402 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.86399841 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.36399841 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.20600128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.70600128 152.12199402 Tm [(NF-)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 109.69799805 152.12199402 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 114.84400177 152.12199402 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.49099731 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.99099731 152.12199402 Tm [(inhibito)1(rs,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.85499573 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.35499573 152.12199402 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.45199585 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.95199585 152.12199402 Tm [(undergoes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.09500122 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.59500122 152.12199402 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.3769989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.8769989 167.72200012 Tm [(upon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.43900299 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93900299 167.72200012 Tm [(TCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.9940033 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.4940033 167.72200012 Tm [(signaling.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.59199524 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.09199524 167.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 139.73800659 167.72200012 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 144.88400269 167.72200012 Tm [(BNS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.04200745 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.54200745 167.72200012 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.83399963 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.33399963 167.72200012 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.69799805 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.19799805 167.72200012 Tm [(po)1(siti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.83100033 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.33100033 183.32200623 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.6079998 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.10800171 183.32200623 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.06999969 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.56999969 183.32200623 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.08599854 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.58599854 183.32200623 Tm [(regulat)1(i)-1(o)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.98300171 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.48300171 183.32200623 Tm [(depending)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.20100403 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.70100403 183.32200623 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.96899414 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.46899414 183.32200623 Tm [(individua)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.39499998 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.89499998 198.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.30500031 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.80500031 198.92199707 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.77600098 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.27600098 198.92199707 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55699921 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.05699921 198.92199707 Tm [(cy)-1(t)1(oki)-1(ne.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.52200317 198.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 0.75 m 154.80000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>