%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 10.2329998 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 59.9090004 23.67700005 Tm 0 Tr [(NFKB)1(IB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.05799866 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.03199768 23.67700005 Tm [(\(Ph)1(osph)1(o-Ser23\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.62600708 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 294.62600708 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 405.06600952 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(NFKB)1(IB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.75099945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.125 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser2)1(3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.21499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 196.46499634 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 248.96499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.21499634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BIB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.85900116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.23300171 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser2)1(3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.32299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.69700623 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.34700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.72099304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.27999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.6539917 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.45001221 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IK)1(BB;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.33300018 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.70700073 12.82499981 Tm [(TRIP9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.91600037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)1(IB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.12599945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.5 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser2)1(3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 136.42500305 0.75 l 136.42500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 137.42500305 -0.25 l 137.42500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.17500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 137.17500305 125.55000305 l h f* Q q 1 0 0 1 136.80000305 0 cm -0.625 -0.25 m 286.625 -0.25 l 286.625 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Inhibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.79000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29000092 11.72200012 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.16699982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.66699982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.17900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.67900085 11.72200012 Tm [(complexin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.85600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.35600281 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.7519989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.2519989 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.52900696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.02900696 11.72200012 Tm [(tr)1(app)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.98699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.48699951 11.72200012 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.73498535 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67599487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17599487 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 27.3220005 Tm [(cy)-1(t)1(oplas)1(m.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.38299942 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.88300323 27.3220005 Tm [(However,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.21199799 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.71199799 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.71299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.21299744 27.3220005 Tm [(unphos)1(phor)1(y)-1(lat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.27900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.77900696 27.3220005 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.49000549 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.99000549 27.3220005 Tm [(resyn)-1(t)1(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(sized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.85000038 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.35000038 42.92200089 Tm [(af)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.3409996 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.8409996 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.25099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.75099945 42.92200089 Tm [(st)1(i)-1(mulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.02899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.52899933 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.08999634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.58999634 42.92200089 Tm [(ab)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.81399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.31399536 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.38900757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.88900757 42.92200089 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.33500671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.83500671 42.92200089 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.71200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.21200562 42.92200089 Tm [(allow)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 58.52199936 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.71699905 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.21699905 58.52199936 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.95200348 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.45200348 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.52700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.02700043 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.02799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.52799988 58.52199936 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.34599304 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.84599304 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.1230011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.6230011 58.52199936 Tm [(pro)1(tec)-1(t)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.55299377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.05299377 58.52199936 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.80099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.30099487 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.37600708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.87600708 58.52199936 Tm [(furt)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.41598511 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.91598511 58.52199936 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(KBA-)1(depe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.61199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.11199951 74.12200165 Tm [(inac)-1(t)1(ivat)1(i)-1(o)1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.16999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.66999817 74.12200165 Tm [(Ass)1(oc)-1(ia)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.95500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.45500183 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.85099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.35099792 74.12200165 Tm [(inhibito)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.88299561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.38299561 74.12200165 Tm [(kappa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.72799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(B-interacting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.91600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.41600037 89.72200012 Tm [(NKIRA)1(S1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.77100372 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.27100372 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.54799652 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.04799652 89.72200012 Tm [(NKIRA)1(S2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.40299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.90299988 89.72200012 Tm [(prevent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.92399597 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.42399597 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.33799744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.83799744 89.72200012 Tm [(ph)1(osph)1(orylati)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 105.3219986 Tm [(renderin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.85400009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.35400009 105.3219986 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.10199738 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.60199738 105.3219986 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.30000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.80000305 105.3219986 Tm [(resista)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.29699707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.79699707 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.87199402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.37199402 105.3219986 Tm [(degra)1(dat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.31700134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.81700134 105.3219986 Tm [(explaining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.24099731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.74099731 105.3219986 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.65499878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(slow)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.93199921 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.43199921 120.92199707 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.3769989 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 136.42500305 0.75 l 136.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.42500305 -0.25 l 137.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.17500305 16.35000038 l h f* Q q 1 0 0 1 136.80000305 0 cm -0.625 -0.25 m 286.625 -0.25 l 286.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.62699986 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 136.42500305 0.75 l 136.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.42500305 -0.25 l 137.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.17500305 16.35000038 l h f* Q q 1 0 0 1 136.80000305 0 cm -0.625 -0.25 m 286.625 -0.25 l 286.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFKBIB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.75 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.25 11.72200012 Tm [(\(Pho)1(spho)1(-Ser2)-1(3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.39499664 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 136.42500305 0.75 l 136.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.42500305 -0.25 l 137.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 137.17500305 16.35000038 l h f* Q q 1 0 0 1 136.80000305 0 cm -0.625 -0.25 m 286.625 -0.25 l 286.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(NFKBIB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.61300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.11300659 11.72200012 Tm [(\(Pho)1(spho)1(-Ser2)-1(3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.25799561 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.80000305 0.75 m 136.80000305 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.80000305 126.30000305 m 136.80000305 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.80000305 142.65000916 m 136.80000305 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.80000305 159.00001526 m 136.80000305 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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