%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.76799774 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 140.44400024 23.67700005 Tm 0 Tr [(NFKB)1(IA)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.09199524 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 324.53201294 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(NFKB)1(IA)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.73999786 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.24000549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.74000549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BIA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.22299957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.59700012 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.24699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.6210022 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.17999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.55400085 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IK)1(BA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.6969986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.07099915 12.82499981 Tm [(MAD-3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.93000031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.30400085 12.82499981 Tm [(NFKB)1(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.71800232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)1(IA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.48999786 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 143.92500305 141.1499939 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.15400696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.65400696 11.72200012 Tm [(inhibito)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.18600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.68600464 11.72200012 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(amily,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.12800026 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.62800026 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.72499847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.22499847 27.3220005 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.27400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.77400208 27.3220005 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.14599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.64599609 27.3220005 Tm [(ankrin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.44400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94400024 27.3220005 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.66900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.16900635 27.3220005 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.32899475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.82899475 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.63598633 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.13598633 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nc)-1(o)1(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.40100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.90100098 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.20800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.70800018 42.92200089 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.55200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.05200195 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.94799805 42.92200089 Tm [(REL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.38999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.88999939 42.92200089 Tm [(dimers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.18400574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.68400574 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.75900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.25900269 42.92200089 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.63299561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.13299561 42.92200089 Tm [(NF-kap)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pa)1(-B/)-1(RE)1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.55099869 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.05099869 58.52199936 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.30200195 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.39900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.89900208 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.41700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.91700745 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.28599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.78599548 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.727005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.227005 58.52199936 Tm [(inflammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.772995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.27301025 58.52199936 Tm [(res)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(po)1(n)-1(ses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.62099838 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.12099838 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.9280014 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4280014 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.93499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.43499756 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.74200439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.24200439 74.12200165 Tm [(moves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.39300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.89300537 74.12200165 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.96499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.46499634 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.46600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.96600342 74.12200165 Tm [(cy)-1(t)1(oplas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.43299961 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.93299961 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.20999908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.70999908 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.71099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.21099854 89.72200012 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.02899933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.52899933 89.72200012 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.6230011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.1230011 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.09799957 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.59799957 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.11599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.61599731 89.72200012 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.42599487 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.92599487 89.72200012 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.15899658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.65899658 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.93600464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.43600464 89.72200012 Tm [(CR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(M1-mediated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.84700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.34700012 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.86499786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.36499786 105.3219986 Tm [(expor)1(t.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.45899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.95899963 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.80799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.30799866 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.24899292 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.74899292 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.20500183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.70500183 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.22099304 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.72099304 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.06799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.56799316 105.3219986 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ee)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75899982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.25900078 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.94900131 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.44900131 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.38999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.88999939 120.92199707 Tm [(ec)-1(t)1(odermal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.68699646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.18699646 120.92199707 Tm [(dyspla)1(sia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.5269928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.0269928 120.92199707 Tm [(anhid)1(rotic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.66000366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.16000366 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.55599976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.05599976 120.92199707 Tm [(T-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.51800537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.01800537 120.92199707 Tm [(im)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(munodefici)-1(enc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46199799 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.96199799 136.52200317 Tm [(auto)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2480011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.7480011 136.52200317 Tm [(do)1(mi)-1(na)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.47399902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.97399902 136.52200317 Tm [(disease.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.81199646 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFKBIA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.43600082 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 0.75 m 143.55000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 141.8999939 m 143.55000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 158.25 m 143.55000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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