%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 86 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 112.43499756 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 272.55099487 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.86499023 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 139.125 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.33700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.71099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Gol)-1(d-con)-1(jugated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.05400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42799377 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.13600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.50999451 12.82499981 Tm [(anti)-1(-rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.8480072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.22200012 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.43400574 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500160008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0019001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Gol)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.08699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.58699799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 158.17500305 0.75 l 158.17500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 159.17500305 -0.25 l 159.17500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.92500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 158.92500305 187.94999695 l h f* Q q 1 0 0 1 158.55000305 0 cm -0.625 -0.25 m 264.875 -0.25 l 264.875 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(rot)1(e)-1(ins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.72500038 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.22499847 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.16600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.66600037 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.35399628 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.85399628 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.25 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.75 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.25700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.75700378 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.6499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.1499939 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.22200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.72200012 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.44900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.94900513 27.3220005 Tm [(mg/m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.39499998 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.89499998 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.83600044 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.33600044 42.92200089 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.36100006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.86100006 42.92200089 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.8710022 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.46600342 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.02700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52700043 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.48800659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.98800659 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.26600647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.76600647 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.47000122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.97000122 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.87800598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.37800598 42.92200089 Tm [(ag)1(ain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.51900005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.01900005 58.52199936 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.11399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.61399841 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.89099884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.39099884 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.39199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.89199829 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.2749939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.7749939 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.29299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.79299927 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.37800598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.87800598 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.38999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.64699984 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.14700031 74.12200165 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.15200043 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.29299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.79299927 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.76799774 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.26799774 74.12200165 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.77999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.27999878 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.12200165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.62200165 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.32600403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.82600403 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.85899353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.35899353 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.81799316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.31799316 74.12200165 Tm [(respo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nse.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.98500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.48500061 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.29199982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.79199982 89.72200012 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.88700104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.38700104 89.72200012 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.60399628 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.10399628 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.78600311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.28600311 89.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.46699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.96699524 89.72200012 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.83299255 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.33299255 89.72200012 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.40600586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.90600586 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.98100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.48100281 89.72200012 Tm [(bi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.87800026 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.37800026 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.37900162 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.87900162 105.3219986 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.6269989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.1269989 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.34899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84899902 105.3219986 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.86999512 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.36999512 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.3710022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.8710022 105.3219986 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.86799622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.36799622 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.64500427 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.14500427 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.22000122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.72000122 105.3219986 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(cru)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.24399948 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.74399948 120.92199707 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.90299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.40299988 120.92199707 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.97899628 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.47899628 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.7559967 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.2559967 120.92199707 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.63900757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.13900757 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.21400452 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.71400452 120.92199707 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.01800537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.51800537 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.51899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.01899719 120.92199707 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.86300659 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.36300659 120.92199707 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 136.52200317 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.70299911 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.20299911 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.04499817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.54499817 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.54599762 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.04599762 136.52200317 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14099884 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.64099884 136.52200317 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.227005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.727005 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.28799438 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.78799438 136.52200317 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93099976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.43099976 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.94299316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.44299316 136.52200317 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.5 136.52200317 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ec)-1(omb)1(in)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.45399857 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.95399857 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.23100281 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.73100281 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.73200226 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.23200226 152.12199402 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04800415 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.54800415 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.38999939 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.88999939 152.12199402 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26300049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.76300049 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.70399475 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.20399475 152.12199402 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.7250061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2250061 152.12199402 Tm [(indi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(vidual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.79199982 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.29199982 167.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61999893 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11999893 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.09500122 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.59500122 167.72200012 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.1230011 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.6230011 167.72200012 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.91100311 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.41100311 167.72200012 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.17500305 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.67500305 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.23599243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.73599243 167.72200012 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.3809967 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.8809967 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.95599365 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.45599365 167.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.30999756 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.80999756 167.72200012 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.92100525 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.42100525 167.72200012 Tm [(va)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(riant)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.03800011 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 158.17500305 0.75 l 158.17500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 159.17500305 -0.25 l 159.17500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.92500305 0.75 m 422.42498779 0.75 l 422.42498779 47.54999924 l 158.92500305 47.54999924 l h f* Q q 1 0 0 1 158.55000305 0 cm -0.625 -0.25 m 264.875 -0.25 l 264.875 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(-)1(1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90599823 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18399811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.68399811 11.72200012 Tm [(immun)-1(o)1(e)-1(lec)-1(t)1(ron)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.43699646 11.72200012 Tm [(mic)-1(r)1(osc)-1(o)1(py\(IEM\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.41499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.91499329 11.72200012 Tm [(immun)-1(o)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(old)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.8739996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 27.3220005 Tm [(st)1(ain)-1(ing)1(\(IGS\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.21700287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.71700287 27.3220005 Tm [(go)1(l)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.84700012 27.3220005 Tm [(immun)-1(o)1(c)-1(h)1(romat)1(ogra)1(phy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.83799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.33799744 27.3220005 Tm [(assa)1(y)-1(\(G)1(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(CA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35900021 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 235.5 cm q /GS2 gs 1 g 0.375 0.75 m 158.17500305 0.75 l 158.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.17500305 -0.25 l 159.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Co)-1(nj)1(uga)1(te)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.49900055 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 158.92500305 16.35000038 l h f* Q q 1 0 0 1 158.55000305 0 cm -0.625 -0.25 m 264.875 -0.25 l 264.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Go)1(l)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.56599998 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.06599998 11.72200012 Tm [(\(15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.62799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.12799835 11.72200012 Tm [(nm\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.11299896 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 251.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.55000305 0.75 m 158.55000305 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.55000305 188.69999695 m 158.55000305 235.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.55000305 236.25 m 158.55000305 251.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 251.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 235.875 m 422.42498779 235.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 252.2250061 m 423.17498779 252.2250061 l S Q Q q 1 0 0 1 0 526.23400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 554.17297363 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 582.11199951 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>