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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 99.13700104 23.67700005 Tm 0 g [(HRP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 142.61099243 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 280.63900757 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.16299438 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(HRP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 72.79199982 12.82499981 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 138.41700745 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.98199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.35600281 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(HRP-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.13500214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.50900269 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.21699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.59100342 12.82499981 Tm [(anti)-1(-hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.2460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.61999512 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.18499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(HRP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 72.79199982 12.82499981 Tm [<0003000400130007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 114.79199982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.66699982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 102.67500305 156.75 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 321.125 -0.25 l 321.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 11.72200012 Tm [(normally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86199951 11.72200012 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 11.72200012 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42399597 11.72200012 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.48599243 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82800293 11.72200012 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01600647 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.42700195 11.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.62298584 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.25899887 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.75899887 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.31999969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.81999969 27.3220005 Tm [(pro)1(min)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.10600281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.60600281 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.54699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.04699707 27.3220005 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.7230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.2230072 27.3220005 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.68200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.18200684 27.3220005 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.34500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.84500122 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.91999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.41999817 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.09399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.59399414 27.3220005 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.43798828 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.33799934 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.83799934 42.92200089 Tm [(larg)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.66600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.16600037 42.92200089 Tm [(confine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.8710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.3710022 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.44599915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.94599915 42.92200089 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.63699341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.13699341 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.54600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.04600525 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.1210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.6210022 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.53500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.03500366 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.70399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.20399475 42.92200089 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.46299744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.96299744 42.92200089 Tm [(Monomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.63000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.13000488 42.92200089 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55000019 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.04999924 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.61100006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.11100006 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.26499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.76499939 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.90599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.40599823 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.3809967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.8809967 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.66499329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.16499329 58.52199936 Tm [(bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.48300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.98300171 58.52199936 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.24200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.74200439 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.00999451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.50999451 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.51098633 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.01098633 58.52199936 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.87399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.37399292 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.21600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.64699984 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.14700031 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.72299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.22299957 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.5 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.14099884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.64099884 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.61599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.11599731 74.12200165 Tm [(pentamer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.81999969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.31999969 74.12200165 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.61999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.11999512 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.66499329 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.16499329 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.17700195 74.12200165 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.86799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.36799622 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.10998535 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.60998535 74.12200165 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.11801147 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.61801147 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.69299316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.19299316 74.12200165 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.90099907 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.40100098 89.72200012 Tm [(valenc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.4240036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.9240036 89.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.12000275 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.62000275 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.18099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.68099976 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.3789978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.8789978 89.72200012 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.53399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.03399658 89.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.44900513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.94900513 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.10800171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.60800171 89.72200012 Tm [(isot)1(y)-1(p)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.52801514 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.08898926 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.58898926 89.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.73300171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.84400177 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.34400177 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.74000168 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.23999786 105.3219986 Tm [(repeating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.66300201 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.16300201 105.3219986 Tm [(epito)1(pe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.50799561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.00799561 105.3219986 Tm [(\(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.28100586 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.78100586 105.3219986 Tm [(pa)1(rticle)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.8690033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.3690033 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.64599609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.14599609 105.3219986 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.44599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.9460144 105.3219986 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.28900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.78900146 105.3219986 Tm [(ce)-1(lls\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.3710022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.33799934 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.83799934 120.92199707 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.5359993 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.0359993 120.92199707 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.69100189 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.19100189 120.92199707 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.60600281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.10600281 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.20100403 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.70100403 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.64199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.14199829 120.92199707 Tm [(activiat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.52200317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.02200317 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.022995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.522995 120.92199707 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.8789978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.3789978 120.92199707 Tm [(pa)1(thw)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(y.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.92999983 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.43000031 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.23699951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.73699951 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75299835 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.03099823 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.53099823 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.53199768 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.03199768 136.52200317 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.01100159 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.51100159 136.52200317 Tm [(constant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.68400574 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.18400574 136.52200317 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.14599609 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.64599609 136.52200317 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.86099243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.36099243 136.52200317 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.18499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.68499756 136.52200317 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.67800903 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.17800903 136.52200317 Tm [(sepa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(rat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.62700081 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.12700081 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.63899994 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.13899994 152.12199402 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.35800171 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.85800171 152.12199402 Tm [(interven)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.76899719 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.26899719 152.12199402 Tm [(seque)-1(nce)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.44900513 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 321.125 -0.25 l 321.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(50)-1(-)1(2)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90599823 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18399811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.68399811 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.35800171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.85800171 11.72200012 Tm [(ap)1(plic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.62199402 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 0.75 m 102.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 157.5 m 102.30000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q q 1 0 0 1 0 447.48400879 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 475.42300415 cm Q Q 1 0 0 -1 0 841.90002441 cm
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