%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 81 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.69799805 23.67700005 Tm 0 g [(HRP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 134.17199707 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 294.28799438 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.60198975 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 69.13899994 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HRP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.29199982 12.82499981 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.41700745 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.00300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 102.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.00900269 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.69999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.07400513 12.82499981 Tm [(anti)-1(-Min)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.43800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.81199646 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.02400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 136.21699524 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.29199982 12.82499981 Tm [<0003000400140007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 125.29199982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 169.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 203.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.66699982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 236.83399963 m 416.75 236.83399963 l 416.75 268.03399658 l -1.45000005 268.03399658 l h f* Q q 1 0 0 1 0 236.83399963 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 268.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 295.97299194 cm q /GS2 gs 1 g 0.375 0.75 m 105.875 0.75 l 105.875 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 106.875 -0.25 l 106.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.625 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 106.625 156.75 l h f* Q q 1 0 0 1 106.25 0 cm -0.625 -0.25 m 320.92498779 -0.25 l 320.92498779 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 83.02200317 11.72200012 Tm [<000D>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 92.02200317 11.72200012 Tm [(IgG)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 107.11699677 11.72200012 Tm [<000E>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 116.11699677 11.72200012 Tm [(,is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.84500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.34500122 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.71899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.21899414 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.56100464 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.56199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.06199646 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.73599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.23599243 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.18099976 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.6539917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.1539917 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.09500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.59500122 11.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(erum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.52199936 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.02199936 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.41799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.91799927 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.42500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.92500305 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.81800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.31800079 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.38999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.88999939 27.3220005 Tm [(9.5)-1(-)1(1)-1(2.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.5059967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.0059967 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.8690033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.3690033 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.30999756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.80999756 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.83499146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.33499146 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.84500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.34500122 27.3220005 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.69299984 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.19299984 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75399971 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25399971 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71499634 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.49299622 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.1969986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6969986 42.92200089 Tm [(defenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.95199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45199585 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.61799622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.11799622 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.21299744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.71299744 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.98999023 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.48999023 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.49099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.99099731 42.92200089 Tm [(mol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ec)-1(ule)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.83300018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.33300018 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.85100174 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.35100174 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.93599701 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.43599701 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.94799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.44799805 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.09500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.59500122 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.1000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.6000061 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.74099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.24099731 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.21600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.71600342 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.22799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.72799683 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.57000732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.07000732 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.77400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.27398682 58.52199936 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.30700684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.80700684 58.52199936 Tm [(im)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mune)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63100052 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13100052 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.29499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.79499817 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.60199738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.10199738 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1969986 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.6969986 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.91400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.41400146 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.09599304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.59599304 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.7769928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.2769928 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.14300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.64300537 74.12200165 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.71600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.21600342 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.29098511 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.79098511 74.12200165 Tm [(bi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.87800026 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.37800026 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.37900162 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.87900162 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.6269989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.1269989 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.34899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84899902 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.86999512 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.36999512 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.3710022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.8710022 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.86799622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.36799622 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.64500427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.14500427 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.22000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.72000122 89.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.50698853 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.00698853 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.16598511 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.66598511 89.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ell)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.06200027 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.56200027 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.8390007 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.3390007 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.22200012 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.29699707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.79699707 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10099792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.60099792 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.602005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.102005 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.94599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.44599915 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.25300598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.75300598 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.30801392 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.80801392 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.6499939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.1499939 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.15100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.65100098 105.3219986 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.7460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.58600044 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.08600044 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.64699936 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.14699936 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.29000092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.79000092 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.30200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.80200195 120.92199707 Tm [(Somat)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.38699341 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.88699341 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.7769928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.2769928 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.55400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.05400085 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.05499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.55499268 120.92199707 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.3710022 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.8710022 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.7130127 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.2130127 120.92199707 Tm [(spe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ci)-1(f)1(ic)-1(ities)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.35200119 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.85200119 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.79299927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.29299927 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.81399918 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.31400299 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.19799805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.69799805 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.02600098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.52600098 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.50100708 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.00100708 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.52900696 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.02900696 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.31700134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.81700134 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.58099365 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.08099365 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64199829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.14199829 136.52200317 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.7869873 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.2869873 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.36199951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.86199951 136.52200317 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.71600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.21600342 136.52200317 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.79199982 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 105.875 0.75 l 105.875 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 106.875 -0.25 l 106.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.625 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 106.625 31.95000076 l h f* Q q 1 0 0 1 106.25 0 cm -0.625 -0.25 m 320.92498779 -0.25 l 320.92498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.73899841 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.51699829 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2559967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.7559967 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.99499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.49499512 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.772995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.272995 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64599609 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.91499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41500854 11.72200012 Tm [(1/)-1(20)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.09899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.59899902 11.72200012 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.8690033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.3690033 27.3220005 Tm [(1/)-1(20)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.05299377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.55299377 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.83099365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.33099365 27.3220005 Tm [(Immunoc)-1(yt)1(oc)-1(ehmist)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.71600342 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.25 0.75 m 106.25 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.25 157.5 m 106.25 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 426.17498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 426.92498779 189.07499695 l S Q Q q 1 0 0 1 0 485.42300415 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>