%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 81 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 101.74199677 23.67700005 Tm 0 g [(HRP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 145.21600342 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 283.24398804 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.55801392 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HRP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.29199982 12.82499981 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 148.91700745 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.1289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.50300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.00900269 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.69999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.07400513 12.82499981 Tm [(anti)-1(-chi)-1(ck)1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.08200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.45599365 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.66799927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.29199982 12.82499981 Tm [<0003000400130007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 125.29199982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.66699982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 107.17500305 156.75 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 83.02200317 11.72200012 Tm [<000D>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 92.02200317 11.72200012 Tm [(IgG)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 107.11699677 11.72200012 Tm [<000E>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 116.11699677 11.72200012 Tm [(,is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.84500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.34500122 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.71899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.21899414 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.56100464 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.56199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.06199646 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.73599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.23599243 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.18099976 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.6539917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.1539917 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.09500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.68799973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.18799973 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08399963 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.09100342 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48400116 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.05599976 27.3220005 Tm [(9.5)-1(-)1(1)-1(2.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.67199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.17199707 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53500366 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.47599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.97599792 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.00100708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.50100708 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.01098633 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.51098633 27.3220005 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(gG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44999981 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.95000076 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.51099968 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.01099968 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.97200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.47200012 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.75 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.25 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.95400238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.45400238 42.92200089 Tm [(defenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.70899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.20899963 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.375 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.875 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.97000122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.47000122 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.74700928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.24700928 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.24798584 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.74798584 42.92200089 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(olec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95000076 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45000076 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.9679985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4679985 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.0530014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.5530014 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.06500244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.56500244 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.21199799 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.71200562 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.21699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.71699524 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.85800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.35800171 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.33299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.83299255 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.34500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.84500122 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.68699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.18699646 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.89099121 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.39099121 58.52199936 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.42401123 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.45899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.95899963 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.1230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.6230011 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.43000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.93000031 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.02500153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.52500153 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.74200439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.24200439 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.92399597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.42399597 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.60499573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.10499573 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.97099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.47099304 74.12200165 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.54400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.04400635 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.11898804 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.02099991 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.52099991 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52199936 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.02199936 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.76999664 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26999664 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.49199677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.99199677 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.01300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.51300049 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.51400757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.01400757 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.01100159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.51100159 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.28799438 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.36300659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.86300659 89.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.6499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.1499939 89.72200012 Tm [(ot)1(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.51300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.01300049 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.29000092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.79000092 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.17299652 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.67299652 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.7480011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.2480011 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.55200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.05200195 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.05299377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.55299377 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.39700317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.89700317 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.70399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.20399475 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.75900269 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.25900269 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.10101318 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.60101318 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.60198975 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.09500027 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.59499931 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.18099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.68099976 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.24200058 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.74200058 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.88500214 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.38500214 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.89700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.39700317 120.92199707 Tm [(Somat)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.98199463 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.48199463 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.37199402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.87199402 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.14900208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.64900208 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.6499939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.1499939 120.92199707 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.96600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.46600342 120.92199707 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.99300003 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.49300003 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.43399811 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.93399811 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.45500183 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.95500183 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.83900452 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.33900452 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.66700745 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.16700745 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.14199829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.64199829 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.16999817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.66999817 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.95799255 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.45799255 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.22200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.72200012 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.28300476 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.78300476 136.52200317 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.42800903 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.92800903 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.00299072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.85400009 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35400009 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.46500015 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.96500015 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.7009964 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 107.17500305 31.95000076 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.73899841 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.51699829 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2559967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.7559967 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.99499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.49499512 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.772995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.272995 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64599609 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.91499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41500854 11.72200012 Tm [(1/)-1(20)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.09899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.77799988 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.89399719 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 0.75 m 106.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 157.5 m 106.80000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 463.08401489 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 491.02301025 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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