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10.5 Tf 1 0 0 -1 135.79200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.04200745 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.00900269 12.82499981 Tm [(Av)1(i)-1(di)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.67900085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000F00100011000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.66699982 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.37400055 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.37400055 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 75.27500153 0.75 l 75.27500153 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 76.27500153 -0.25 l 76.27500153 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 76.02500153 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 76.02500153 172.3500061 l h f* Q q 1 0 0 1 75.65000153 0 cm -0.625 -0.25 m 347.7749939 -0.25 l 347.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Avid)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.14900017 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.64900017 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.20999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.70999908 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.68500137 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.18500137 11.72200012 Tm [(tetr)1(americ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.29299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.79299927 11.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.9509964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.4509964 11.72200012 Tm [(dimeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.48699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.98699951 11.72200012 Tm [(biot)1(in-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.18299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.68299866 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.99000549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.49000549 11.72200012 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.07501221 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.57501221 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.51599121 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.01599121 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.51699829 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(viducts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.45400047 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95399857 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.79600143 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.29600143 27.3220005 Tm [(bird)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.96499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.46499634 27.3220005 Tm [(rept)1(i)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.17199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.67199707 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.94900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.44900513 27.3220005 Tm [(amp)1(hibians)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.3710022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.8710022 27.3220005 Tm [(depo)1(sited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.98100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.48100281 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.42199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.92199707 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.92300415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.42300415 27.3220005 Tm [(wh)1(ites)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.59100342 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.43301392 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.93301392 27.3220005 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.76599121 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(eggs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.95299911 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.45299911 42.92200089 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.64400101 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.14400101 42.92200089 Tm [(chic)-1(ke)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.65899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.15899658 42.92200089 Tm [(egg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.77899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.27899933 42.92200089 Tm [(wh)1(ite,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.9469986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.44700623 42.92200089 Tm [(avid)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.23899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.73899841 42.92200089 Tm [(make)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.31900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.81900024 42.92200089 Tm [(up)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.11300659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.61300659 42.92200089 Tm [(ap)1(prox)1(i)-1(ma)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.22399902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.72399902 42.92200089 Tm [(0.0)-1(5%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73098755 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.23098755 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.07299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.57299805 42.92200089 Tm [(to)1(tal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.36999512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 58.52199936 Tm [(\(ap)1(prox)1(i)-1(ma)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.4240036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.9240036 58.52199936 Tm [(1.8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.64600372 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.14600372 58.52199936 Tm [(mg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.33599854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.83599854 58.52199936 Tm [(per)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.1269989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.6269989 58.52199936 Tm [(egg\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.41900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.91900635 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.72599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.22599792 58.52199936 Tm [(tetr)1(americ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.33399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.83399963 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.14099121 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.64099121 58.52199936 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.85598755 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.35598755 58.52199936 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.70400047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.20400047 74.12200165 Tm [(identical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.63899994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.13899994 74.12200165 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.60500336 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.10500336 74.12200165 Tm [(\(ho)1(motetra)1(me)-1(r\))1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.90100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.40100098 74.12200165 Tm [(eac)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.53700256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.03700256 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.8789978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.3789978 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.47599792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.97599792 74.12200165 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.01000977 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.51000977 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.95599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.45599365 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.53100586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.03100586 74.12200165 Tm [(biot)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.19000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.69000244 74.12200165 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(Vitamin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.18299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.68299866 89.72200012 Tm [(B7)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.77399826 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.27399826 89.72200012 Tm [(vita)1(min)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.09500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.59500122 89.72200012 Tm [(H\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.56199646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.06199646 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.45800018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.95799255 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43299866 89.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.66799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.16799927 89.72200012 Tm [(degree)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.43800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.93800354 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.77999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.27999878 89.72200012 Tm [(af)1(fini)-1(t)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.94700623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.44700623 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.72399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.22399902 89.72200012 Tm [(speci)-1(f)1(ic)-1(it)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.85900879 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.35900879 89.72200012 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.54998779 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.04998779 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.96398926 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(tetr)1(americ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.10800171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.60800171 105.3219986 Tm [(fo)1(rm,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.48600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.98600006 105.3219986 Tm [(avid)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.77799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.27799988 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.83899689 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.33899689 105.3219986 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.98399353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.48399353 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.55900574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05900574 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.91299438 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.41299438 105.3219986 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.48500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.98500061 105.3219986 Tm [(66)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.54100037 105.3219986 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.40100098 105.3219986 Tm [(69)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.95700073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.45700073 105.3219986 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.18701172 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.68701172 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.62799072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.12799072 105.3219986 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.38699341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.88699341 105.3219986 Tm [(Te)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.69900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(perce)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.81000137 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.31000137 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.15200043 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.65200043 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.65299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.15299988 120.92199707 Tm [(molec)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.6740036 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.1740036 120.92199707 Tm [(weigh)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.43299866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.93299866 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.4940033 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.9940033 120.92199707 Tm [(at)1(trib)1(u)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.01600647 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.59100342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.09100342 120.92199707 Tm [(carbo)1(hydrat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.41799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.91799927 120.92199707 Tm [(conten)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.05700684 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.55700684 120.92199707 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(mpo)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.93199921 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.43199921 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.27399826 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.77399826 136.52200317 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.59799957 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.09799957 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.17299652 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.67299652 136.52200317 Tm [(five)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01899719 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51899719 136.52200317 Tm [(mannose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.01300049 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.51300049 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.78999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.28999329 136.52200317 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.83399963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.33399963 136.52200317 Tm [(N-a)1(c)-1(etylgluc)-1(o)1(samine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.20401001 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.70401001 136.52200317 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.54998779 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 152.12199402 Tm [(carbo)1(hydrat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.63400269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.13400269 152.12199402 Tm [(moieties)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.81099701 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.31099701 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.15299988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.65299988 152.12199402 Tm [(avid)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.44500732 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94500732 152.12199402 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.9940033 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.4940033 152.12199402 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.82200623 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.32200623 152.12199402 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.31700134 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.81700134 152.12199402 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.36099243 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.86099243 152.12199402 Tm [(uni)-1(q)1(ue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.75698853 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.25698853 152.12199402 Tm [(oligo)1(sac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(charide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.72400093 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.22399902 167.72200012 Tm [(st)1(ruc)-1(tura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.94400024 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.44400024 167.72200012 Tm [(types)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.58100128 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.08100128 167.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.3030014 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.80299377 167.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.32099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.82099915 167.72200012 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.01600647 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.51600647 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.45700073 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.95700073 167.72200012 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.41400146 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.91400146 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.19099426 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.69100952 167.72200012 Tm [(composit)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.57199097 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 75.27500153 0.75 l 75.27500153 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 76.27500153 -0.25 l 76.27500153 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 76.02500153 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 76.02500153 31.95000076 l h f* Q q 1 0 0 1 75.65000153 0 cm -0.625 -0.25 m 347.7749939 -0.25 l 347.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.73899841 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.51699829 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2559967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.7559967 11.72200012 Tm [(1/)-1(50)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.71699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.21699524 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.49499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.99499512 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.86799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.36799622 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.63699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.13699341 11.72200012 Tm [(1/)-1(20)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.8210144 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.3210144 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.59899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.09899902 11.72200012 Tm [(Im)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(munohist)1(oc)-1(h)1(e)-1(mist)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.13200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.63200378 27.3220005 Tm [(1/)-1(20)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.31599426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.81599426 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.09399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.59399414 27.3220005 Tm [(Immunoc)-1(yt)1(oc)-1(ehmist)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.97900391 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 75.65000153 0.75 m 75.65000153 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 75.65000153 173.1000061 m 75.65000153 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q q 1 0 0 1 0 478.68399048 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 506.62298584 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 534.56201172 cm Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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6 0 obj
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