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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.18699646 23.67700005 Tm 0 g [(HMMR)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.40899658 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.11300659 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HMMR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 98.44799805 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.44799805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HMMR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.5719986 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.147995 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.12800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.5019989 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.97599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(hyal)-1(uronan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.48600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.86000061 12.82499981 Tm [(me)1(d)-1(iated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.68600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.05999756 12.82499981 Tm [(moti)-1(li)-1(ty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.00100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.375 12.82499981 Tm [(re)1(ceptor;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.96499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33900452 12.82499981 Tm [(CD168;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.17199707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.54598999 12.82499981 Tm [(IHABP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.7539978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.12799072 12.82499981 Tm [(RHAMM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 335.40100098 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(395-5)1(94)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(HMMR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 398.63400269 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.5289917 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(hyaluronan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.44499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.94499969 11.72200012 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.82700348 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.32700348 11.72200012 Tm [(mot)1(il)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.13699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.63699341 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05900574 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CD16)-1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.87599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.37599945 11.72200012 Tm [(IHABP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.63500214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.13500214 11.72200012 Tm [(RHAMM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.89099884 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O75)-1(33)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(08)-1(90)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.57499695 16.35000038 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 99.82499695 0.75 l 99.82499695 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 100.82499695 -0.25 l 100.82499695 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.57499695 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 100.57499695 78.75 l h f* Q q 1 0 0 1 100.19999695 0 cm -0.625 -0.25 m 326.9750061 -0.25 l 326.9750061 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.53500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.03500366 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.97599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.47599792 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.88600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.38600159 11.72200012 Tm [(mot)1(il)-1(it)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.86199951 11.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.86099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.36099243 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.92199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.42199707 11.72200012 Tm [(exp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.73800087 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.23799896 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.17900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.67900085 27.3220005 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.46399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.96399689 27.3220005 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.69599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.19599915 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.47299957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.97299957 27.3220005 Tm [(to)1(gether)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.3480072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.8480072 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.2440033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.7440033 27.3220005 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.90299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.40299988 27.3220005 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.04199219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.54199219 27.3220005 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.29000854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.79000854 27.3220005 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.66699219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.16699219 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.14199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.64199829 27.3220005 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(omp)1(l)-1(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9659996 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.4659996 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.86199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 42.92200089 Tm [(BRCA1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.51499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.01499939 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.29199982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.79199982 42.92200089 Tm [(BRCA2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.11199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.61199951 42.92200089 Tm [(th)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.21800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.71800232 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.27900696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.77900696 42.92200089 Tm [(po)1(ten)-1(t)1(ially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.52999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.02999878 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.15701294 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.65701294 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.05300903 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.55300903 42.92200089 Tm [(hi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gh)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.8409996 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.3409996 58.52199936 Tm [(risk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.23799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.73799896 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.58000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.08000183 58.52199936 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.86499786 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.36499786 58.52199936 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.6210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.1210022 58.52199936 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.0019989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.5019989 58.52199936 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.58299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.08299255 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.00500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.50500488 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.07501221 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.57501221 58.52199936 Tm [(en)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(od)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.1760006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6760006 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.61599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.11599731 74.12200165 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.27600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.77600098 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.1230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.6230011 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.13000488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.63000488 74.12200165 Tm [(noted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.11399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.61399841 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.89199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.39199829 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.8480072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.3480072 74.12200165 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.02999878 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 0.75 m 100.19999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 17.10000038 m 100.19999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 33.45000076 m 100.19999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 49.80000305 m 100.19999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 66.15000153 m 100.19999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 82.5 m 100.19999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 98.84999847 m 100.19999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.19999695 115.19999695 m 100.19999695 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 589.41802979 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm
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