%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 77.41400146 23.67700005 Tm 0 g [(HMGN5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.18200684 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 161.18200684 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 337.88598633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HMGN)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.24299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.49299622 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.49299622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HMGN)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.24299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.61699677 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.81900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.19299316 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.17300415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.54699707 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.02099609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(hi)-1(gh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.38500214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.75900269 12.82499981 Tm [(mob)-1(il)-1(ity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.6989975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.07299805 12.82499981 Tm [(gr)1(o)-1(up)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.2460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.61999512 12.82499981 Tm [(nu)-1(cleosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.52000427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.89399719 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.72200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.09599304 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.49301147 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.86700439 12.82499981 Tm [(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.99798584 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.37200928 12.82499981 Tm [(NSBP1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.24099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.61499023 12.82499981 Tm [(NB)1(P-45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.38699341 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.20599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.58000183 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.73500061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10899353 12.55799961 Tm [(130)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.07400513 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.44799805 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.32899475 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.70300293 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.20498657 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.57901001 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.32000732 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.69400024 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.66101074 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.03500366 12.55799961 Tm [(HMGN)1(5)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 336.27801514 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.73500061 11.72200012 Tm [(mob)1(i)-1(lit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.93999863 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.43999863 11.72200012 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.64900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14900208 11.72200012 Tm [(nuc)-1(leosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.40400696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.90400696 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.04800415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.54800415 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.375 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.875 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.15299988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NSB)-1(P)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.10899925 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.60900116 11.72200012 Tm [(NBP-45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.52799988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P82)-1(97)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(05)-1(34)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.27500153 16.35000038 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 98.52500153 0.75 l 98.52500153 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 99.52500153 -0.25 l 99.52500153 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.27500153 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 99.27500153 63.15000153 l h f* Q q 1 0 0 1 98.90000153 0 cm -0.625 -0.25 m 328.2749939 -0.25 l 328.2749939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.18800354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.68800354 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.99499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.49499512 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.89100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.39100647 11.72200012 Tm [(similarit)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.0019989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.5019989 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.57699585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.07699585 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.07800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.57800293 11.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.81298828 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.31298828 11.72200012 Tm [(mob)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.30200005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.80200005 27.3220005 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.01100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.51100159 27.3220005 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.15000153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.65000153 27.3220005 Tm [(HMG1)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.65299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.15299988 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.42999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.92999268 27.3220005 Tm [(HMG1)-1(7,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.09899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.59899902 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.69599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.19599915 27.3220005 Tm [(sugg)1(e)-1(st)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.2130127 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.7130127 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.93499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.43499756 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.89099121 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.39099121 27.3220005 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.39999962 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.07099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.57099915 42.92200089 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.31199646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.81199646 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.95300293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.45300293 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.4280014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.9280014 42.92200089 Tm [(nuc)-1(leosomal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.44700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.94700623 42.92200089 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.09100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.59100342 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.86799622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.36799622 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.32199097 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.82199097 42.92200089 Tm [(activat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 58.52199936 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.67100143 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 0.75 m 98.90000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 17.10000038 m 98.90000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 33.45000076 m 98.90000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 49.80000305 m 98.90000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 66.15000153 m 98.90000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 82.5 m 98.90000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 98.84999847 m 98.90000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.90000153 115.19999695 m 98.90000153 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 561.47900391 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>