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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.63600159 23.67700005 Tm 0 g [(HI)1(F1A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.95899963 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.95899963 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.66299438 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HIF1A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.40899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 93.65899658 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.65899658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HIF1A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.40899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.78299713 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.98500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.35900116 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.33900452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.71299744 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.18699646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(hypo)-1(xia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.30999756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.57099915 12.82499981 Tm [(in)-1(du)-1(cibl)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.53100586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.79200745 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.18099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.44200134 12.82499981 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.38400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.64500427 12.82499981 Tm [(alp)-1(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.14700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.40800476 12.82499981 Tm [(su)-1(bun)-1(it;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.31700134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.57800293 12.82499981 Tm [(HIF1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.7210083 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.98199463 12.82499981 Tm [(MOP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.4670105 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.72799683 12.82499981 Tm [(PA)1(S)-1(D8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 335.64401245 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.90499878 12.82499981 Tm [(HIF-)-1(1)1(A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 370.3380127 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.59899902 12.82499981 Tm [(bHL)-1(He)1(78;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29098511 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(HIF-)-1(1)1(al)-1(ph)-1(a;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.86000061 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.23400116 30.49699783 Tm [(HIF1-ALPHA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.31400299 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(576-8)1(25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(HIF1A)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 393.84500122 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 121.77500153 0.75 l 121.77500153 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 122.77500153 -0.25 l 122.77500153 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.52500153 0.75 m 426.17498779 0.75 l 426.17498779 187.94999695 l 122.52500153 187.94999695 l h f* Q q 1 0 0 1 122.15000153 0 cm -0.625 -0.25 m 305.0249939 -0.25 l 305.0249939 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.69599915 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.33000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.83000183 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.13000488 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.63000488 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.47200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.97200012 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.05599976 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.17498779 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.67498779 11.72200012 Tm [(hypo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(xia-)1(in)-1(d)1(uc)-1(ible)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.22600174 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.72600174 27.3220005 Tm [(fa)1(c)-1(t)1(or-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.01699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.51699829 27.3220005 Tm [(\(HIF)-1(-)1(1)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.2539978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.7539978 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.85099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.35099792 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.91200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.41200256 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.38699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.88699341 27.3220005 Tm [(heterod)1(ime)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.28100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.78100586 27.3220005 Tm [(composed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.94799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.86300087 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.36300087 42.92200089 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.99700165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.49700165 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.77400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.27400208 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.24900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.74900055 42.92200089 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.93099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.43099976 42.92200089 Tm [(subunit.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.89700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.39700317 42.92200089 Tm [(HIF)-1(-)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.95599365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.45599365 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.36300659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.86300659 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.0039978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.5039978 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.47900391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.97900391 42.92200089 Tm [(mast)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.44900513 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.94900513 42.92200089 Tm [(reg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ulato)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.42700005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.92700005 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.76900101 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.26900101 58.52199936 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.03099823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.53099823 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.80799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.30799866 58.52199936 Tm [(systemic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.20399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.70399475 58.52199936 Tm [(ho)1(me)-1(os)1(tat)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.98300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.48300171 58.52199936 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.47999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.97999573 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.55499268 58.52199936 Tm [(hypo)1(xia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.26098633 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 74.12200165 Tm [(activat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.99700165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.49700165 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.08100128 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.58100128 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.42300415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.92300415 74.12200165 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.63999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.13999939 74.12200165 Tm [(gene)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.98800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.48800659 74.12200165 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.83799744 74.12200165 Tm [(th)1(ose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.72698975 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.22698975 74.12200165 Tm [(involv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 89.72200012 Tm [(en)-1(erg)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.52000046 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.02000046 89.72200012 Tm [(metab)1(olism,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.91300201 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.41300201 89.72200012 Tm [(angio)1(gen)-1(esis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.21600342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.71600342 89.72200012 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.8769989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.3769989 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.65400696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.15400696 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.31298828 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.81298828 89.72200012 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 105.3219986 Tm [(wh)1(ose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.41400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.91400146 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.22100067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.72100067 105.3219986 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.96199799 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.46199799 105.3219986 Tm [(inc)-1(rease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.70599365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.20599365 105.3219986 Tm [(oxygen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.66200256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16200256 105.3219986 Tm [(delive)-1(r)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.84599304 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.34599304 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.5039978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.0039978 105.3219986 Tm [(fa)1(c)-1(ilitat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.58401489 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(metab)1(olic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.63999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.13999939 120.92199707 Tm [(ad)1(apt)1(atio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.93699646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.43699646 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.51200104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.01200104 120.92199707 Tm [(hypo)1(xia.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.88499451 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.38499451 120.92199707 Tm [(HIF)-1(-)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.94400024 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.44400024 120.92199707 Tm [(th)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.05000305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.55000305 120.92199707 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.59700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.09700012 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.61799622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.11799622 120.92199707 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.32598877 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.82598877 120.92199707 Tm [(ro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.50099993 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.0010004 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.94199944 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.44199944 136.52200317 Tm [(embryonic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.10600281 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.60600281 136.52200317 Tm [(vasculariza)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.31300354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.81300354 136.52200317 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.30299377 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.80299377 136.52200317 Tm [(angio)1(gen)-1(esis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.44000244 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.94000244 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.21699524 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.7170105 136.52200317 Tm [(pa)1(tho)1(ph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ysiology)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.68399811 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.18399811 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.02600098 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.52600098 152.12199402 Tm [(ische)-1(mic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.58899689 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.08899689 152.12199402 Tm [(disease.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.92700195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.42700195 152.12199402 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.30799866 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.80799866 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.88900757 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.38900757 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.31100464 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.81100464 152.12199402 Tm [(var)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.06499958 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.56500053 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.9070015 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.4070015 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.34700012 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.84700012 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.00700378 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.50700378 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.85400391 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.35400391 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.86099243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.36099243 167.72200012 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.29200745 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.79200745 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.07000732 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.57000732 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.02600098 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.52600098 167.72200012 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.27299976 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 121.77500153 0.75 l 121.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.77500153 -0.25 l 122.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 122.52500153 16.35000038 l h f* Q q 1 0 0 1 122.15000153 0 cm -0.625 -0.25 m 305.0249939 -0.25 l 305.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 204.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 121.77500153 0.75 l 121.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.77500153 -0.25 l 122.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 122.52500153 16.35000038 l h f* Q q 1 0 0 1 122.15000153 0 cm -0.625 -0.25 m 305.0249939 -0.25 l 305.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 220.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.15000153 0.75 m 122.15000153 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.15000153 188.69999695 m 122.15000153 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.15000153 205.05000305 m 122.15000153 220.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 220.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 426.17498779 188.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 204.67500305 m 426.17498779 204.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 221.02500916 m 426.92498779 221.02500916 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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