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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 73.61100006 23.67700005 Tm 0 g [(HEN)1(MT1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.98399353 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.98399353 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 341.68798828 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(HENMT1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.36299896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.61299896 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.61300659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HENMT1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.86299896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.23699951 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.43899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.81300354 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.79299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.16700745 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.64100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HEN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.76899719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.14299774 12.82499981 Tm [(me)1(th)-1(y)1(l)-1(tr)1(an)-1(sfer)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.23199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.60600281 12.82499981 Tm [(ho)-1(molo)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.47399902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.8480072 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.97900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.35299683 12.82499981 Tm [(HEN1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.30499268 12.82499981 Tm [(C1orf59)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.27099609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(194-3)1(93)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(HENMT1)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 406.29901123 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HEN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.50399971 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.00399971 11.72200012 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.98300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.48300171 11.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.7749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.2749939 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.55299377 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HEN1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.67000008 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.17000008 11.72200012 Tm [(C1orf59)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.30200195 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q5T)-1(8I9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.97299957 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(19)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.47499847 16.35000038 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 110.72499847 0.75 l 110.72499847 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 111.72499847 -0.25 l 111.72499847 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.47499847 0.75 m 426.17501831 0.75 l 426.17501831 94.34999847 l 111.47499847 94.34999847 l h f* Q q 1 0 0 1 111.09999847 0 cm -0.625 -0.25 m 316.07501221 -0.25 l 316.07501221 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Methyltra)1(nsferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.33899689 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.83899689 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.06099701 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.56099701 11.72200012 Tm [(ad)1(ds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.21499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.71499634 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.19000244 11.72200012 Tm [(2')-1(-)1(O-methyl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.48899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.98899841 11.72200012 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.19799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.69799805 11.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.02600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.52600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.5269928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.02700806 11.72200012 Tm [(3')-1(-)1(e)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.91500854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.41500854 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.25698853 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(piRNA)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.47499847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.97499847 27.3220005 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.19000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.69000244 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.53199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.03199768 27.3220005 Tm [(24)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.58799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.08799744 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.16300201 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.66300201 27.3220005 Tm [(30)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.21900177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.71899414 27.3220005 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.15800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.65800476 27.3220005 Tm [(RNA)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.34899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.84899902 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.07099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.57099915 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.08900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.58900452 27.3220005 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.73199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.23199463 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.74398804 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 42.92200089 Tm [(Dice)-1(r-)1(indepe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.64199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14199829 42.92200089 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.25100708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.75100708 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.02799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.52799988 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.04600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.54600525 42.92200089 Tm [(prima)1(rily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.52400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.02400208 42.92200089 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.30599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.80599976 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.51699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.01699829 42.92200089 Tm [(tr)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nspos)1(ons)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.78099823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.28099823 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.55799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.05799866 58.52199936 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.21700287 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.71700287 58.52199936 Tm [(repeated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.30499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.80499268 58.52199936 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.6519928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.1519928 58.52199936 Tm [(ele)-1(ments.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.53100586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.03100586 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.29299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.79299927 58.52199936 Tm [(pro)1(bab)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.32901001 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.82901001 58.52199936 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tects)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.49200058 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.99200058 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.99300003 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.49300003 74.12200165 Tm [(3')-1(-)1(e)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.3809967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.8809967 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.72299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.22299957 74.12200165 Tm [(piRNA)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.05699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.55699921 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.26800537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.76800537 74.12200165 Tm [(uridylatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.05099487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.55099487 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.022995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.522995 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.80000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.29998779 74.12200165 Tm [(subsequent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.34100342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.94499969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.44499969 89.72200012 Tm [(Sta)1(bilizat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.31600189 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.81600189 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.65799713 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.15800476 89.72200012 Tm [(piRNA)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.99200439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.49200439 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05299377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55299377 89.72200012 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.76100159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.26100159 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.03900146 89.72200012 Tm [(ga)1(me)-1(t)1(ogene)-1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.79400635 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 0.75 m 111.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 17.10000038 m 111.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 33.45000076 m 111.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 49.80000305 m 111.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 66.15000153 m 111.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 82.5 m 111.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 98.84999847 m 111.09999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.09999847 115.19999695 m 111.09999847 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92501831 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm
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