%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.99099731 23.67700005 Tm 0 g [(HELL)1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.60499573 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.60499573 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.30899048 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HEL)-1(LS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.3219986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 93.5719986 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.57200623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HEL)-1(LS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.3219986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69599915 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.89800262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.27200317 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.2519989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.62600708 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.1000061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(heli)-1(case)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.98100281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35500336 12.82499981 Tm [(lymph)-1(oi)-1(d-sp)-1(e)1(ci)-1(fic;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.17700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.55099487 12.82499981 Tm [(LS)-1(H;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.14100647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.51499939 12.82499981 Tm [(PA)1(S)-1(G;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.272995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.64700317 12.82499981 Tm [(SMARCA6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.03100586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.40499878 12.82499981 Tm [(Nbla10143)] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.74798584 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(591-8)1(38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(HEL)-1(LS)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 393.75799561 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(helic)-1(as)1(e)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.36500168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.86500168 11.72200012 Tm [(lymphoid)1(-specific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(LSH)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.94000053 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.44000053 11.72200012 Tm [(PA)1(S)-1(G)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.33300018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.83300018 11.72200012 Tm [(SMARCA)1(6)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.8259964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.3259964 11.72200012 Tm [(Nbla101)-1(43)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.1499939 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9NRZ9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.66400146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(30)-1(96)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 132.875 109.94999695 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(lymphoid)1(-sp)1(e)-1(cific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.7749939 11.72200012 Tm [(helic)-1(as)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.13999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.63999939 11.72200012 Tm [(Ot)1(he)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.41200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.91200256 11.72200012 Tm [(helic)-1(as)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.4070015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.9070015 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.84799957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.34799957 27.3220005 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.47799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.97799683 27.3220005 Tm [(involving)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.18200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.68200684 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.18699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.68699646 27.3220005 Tm [(st)1(rand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.91999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.41999817 27.3220005 Tm [(separa)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.00799561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.50799561 27.3220005 Tm [(inc)-1(lu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.45499992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.95499992 42.92200089 Tm [(replic)-1(a)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.70600128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.20600128 42.92200089 Tm [(repair,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.47000122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.97000122 42.92200089 Tm [(rec)-1(o)1(mbination,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.0269928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.5269928 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.80400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.30400085 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.05499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.55499268 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.81698608 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.36800003 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.86800003 58.52199936 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.68099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.18099976 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.2559967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.7559967 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.61000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.11000061 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.47900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.97900391 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.875 58.52199936 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.63699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.13699341 58.52199936 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.48699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.98699951 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4279995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9280014 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.80899811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.30899811 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.2840004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78399658 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.44400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.94400024 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.88500214 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.38500214 74.12200165 Tm [(leu)-1(ke)-1(mo)1(gen)-1(esis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.00300598 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.50300598 74.12200165 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.38400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.88400269 74.12200165 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.96499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.46499634 74.12200165 Tm [(tr)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(script)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.61199951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.11199951 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.68199921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.18199921 89.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.52400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.02400208 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.46400452 89.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.62399292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.12399292 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.47099304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.97099304 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.47799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.97799683 89.72200012 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 0.75 m 132.5 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 17.10000038 m 132.5 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 33.45000076 m 132.5 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 49.80000305 m 132.5 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 66.15000153 m 132.5 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 82.5 m 132.5 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 98.84999847 m 132.5 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 115.19999695 m 132.5 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 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