%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 79 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.74199677 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 292.03399658 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.55801392 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 69.13899994 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000C000D000E000F0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.125 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.69000244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 97.07800293 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 125.01699829 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011000D000E000F0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)-1(-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.06900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.44299316 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.15100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.5249939 12.82499981 Tm [(anti)-1(-hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.17999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.55400085 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.1190033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 152.95599365 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00120013001400150010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.72699738 12.82499981 Tm [<000600070016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 132.727005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.83399963 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.772995 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00180010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0019001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 264.71200562 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 292.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 361.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 113.92500305 0.75 l 113.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 114.92500305 -0.25 l 114.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 114.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 114.67500305 156.75 l h f* Q q 1 0 0 1 114.30000305 0 cm -0.625 -0.25 m 309.125 -0.25 l 309.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 11.72200012 Tm [(normally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86199951 11.72200012 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 11.72200012 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42399597 11.72200012 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.48599243 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82800293 11.72200012 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01600647 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.42700195 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(gM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55000019 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.04999924 27.3220005 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.30899811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.80899811 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37000275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.87000275 27.3220005 Tm [(pro)1(min)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.15599823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.65599823 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.59700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.09700012 27.3220005 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.772995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.272995 27.3220005 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.73199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.23199463 27.3220005 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.39500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.89500427 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.97000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.47000122 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.14401245 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.64401245 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.32299995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.82299995 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.09999847 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.59999847 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.1609993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.6609993 42.92200089 Tm [(larg)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.48899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.98899841 42.92200089 Tm [(confine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.69400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.19400024 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.26899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.76899719 42.92200089 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.46000671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.96000671 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.3690033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.8690033 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.94400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.44400024 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.35800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.85800171 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.52700806 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.02700806 42.92200089 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.28601074 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.78601074 42.92200089 Tm [(Mo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.15200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.65200043 58.52199936 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.84799957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.34799957 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.90899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.40899658 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.56300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.06300354 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.20399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.70399475 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.67900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.17900085 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.96299744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.46299744 58.52199936 Tm [(bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.78100586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.28100586 58.52199936 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.54000854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.04000854 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.30801392 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.80801392 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.80899048 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.86300087 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.36299896 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.20500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.70500183 74.12200165 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.35200119 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.85200119 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.4280014 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.9280014 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.20500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.70500183 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.32099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.82099915 74.12200165 Tm [(pentamer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.5249939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.0249939 74.12200165 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.32499695 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.82499695 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.36999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.86999512 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.38200378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.88200378 74.12200165 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.57299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.07299805 74.12200165 Tm [(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.12300014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.62300014 89.72200012 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.13100052 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.63100052 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.70600128 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.20600128 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.11999893 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.62000275 89.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.85500336 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.35500336 89.72200012 Tm [(valenc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.37799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.87799835 89.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.07400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.57400513 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.13499451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.63499451 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.33299255 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.83299255 89.72200012 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.48800659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.98800659 89.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.40299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.90299988 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.06201172 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.56201172 89.72200012 Tm [(isot)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(pes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02099991 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52099991 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08200073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.58200073 105.3219986 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.72600174 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.22599792 105.3219986 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.06999969 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.56999969 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.96600342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.46600342 105.3219986 Tm [(repeating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.88900757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.38900757 105.3219986 Tm [(epito)1(pe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.73399353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.23399353 105.3219986 Tm [(\(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.50700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.00700378 105.3219986 Tm [(pa)1(rticle)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.09500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.59500122 105.3219986 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.55699921 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.05699921 120.92199707 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.40000153 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.90000153 120.92199707 Tm [(ce)-1(lls\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.48200226 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.98200226 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.25900269 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.75900269 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.31999969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.81999969 120.92199707 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.51800537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.01800537 120.92199707 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.67300415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.17300415 120.92199707 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.58799744 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.08799744 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.18299866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.68299866 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.62399292 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.12399292 120.92199707 Tm [(activiat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.5039978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.0039978 120.92199707 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 136.52200317 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.9620018 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46199799 136.52200317 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08999634 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.58999634 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.39700317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.89700317 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.41299438 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.91299438 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.19099426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.69099426 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.69200134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.19200134 136.52200317 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.17100525 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.67100525 136.52200317 Tm [(constant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.84399414 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.34399414 136.52200317 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.30599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.80599976 136.52200317 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ntains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.97999954 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.47999954 152.12199402 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.30400085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.80400085 152.12199402 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.79699707 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.29699707 152.12199402 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.91999817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.41999817 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.93200684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.43200684 152.12199402 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.65100098 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.15100098 152.12199402 Tm [(interven)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.06199646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.56199646 152.12199402 Tm [(seque)-1(nce)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.74200439 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 113.92500305 0.75 l 113.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 114.92500305 -0.25 l 114.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 114.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 114.67500305 31.95000076 l h f* Q q 1 0 0 1 114.30000305 0 cm -0.625 -0.25 m 309.125 -0.25 l 309.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Opt)1(imal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 11.72200012 Tm [(test)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.97499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.47499847 11.72200012 Tm [(ap)1(plic)-1(at)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [(wo)1(rk)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 11.72200012 Tm [(dilutions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81799316 11.72200012 Tm [(must)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.31599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.81599426 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17001343 11.72200012 Tm [(deter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.23699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.73699951 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.24900055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.74900055 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.75 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.25 27.3220005 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.65899658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.15899658 27.3220005 Tm [(user.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.58000183 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 114.30000305 0.75 m 114.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 114.30000305 157.5 m 114.30000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 551.23999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>