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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 104.5739975 23.67700005 Tm 0 g [(Bi)1(ot)1(in)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.47200012 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 280.4119873 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.72601318 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00080009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.72699738 12.82499981 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 145.852005 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.06399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.43800354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)-1(-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.06900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.44299316 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.13400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.50799561 12.82499981 Tm [(Anti-)-1(Dog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.18099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.55499268 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000F00100011000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.72699738 12.82499981 Tm [<0003000400120006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 132.727005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 48.70299911 Tm /GS2 gs 0 g [<0013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 48.70299911 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 48.70299911 Tm [<0014000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 48.70299911 Tm /GS2 gs 0 g [<001500160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 48.70299911 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 48.70299911 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001A000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.10199738 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 216.83399963 m 416.75 216.83399963 l 416.75 248.03399658 l -1.45000005 248.03399658 l h f* Q q 1 0 0 1 0 216.83399963 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 275.97299194 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 107.17500305 156.75 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.44000244 11.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(erum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.52199936 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.02199936 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.41799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.91799927 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.42500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.92500305 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.81800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.31800079 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.38999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.88999939 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.61700439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.11700439 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.20399475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.70399475 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.64500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.14500427 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.16999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.66999817 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.17999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.67999268 27.3220005 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.7749939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.2749939 27.3220005 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.1269989 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.40499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.90499878 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.60900116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.10900116 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.51699829 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.18299866 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.27799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.77799988 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.55499268 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.55599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.05599976 42.92200089 Tm [(molec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ule)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.23099899 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.73099899 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.31600189 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.81600189 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.32800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.82800293 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.97499847 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.47999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.97999573 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.1210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.6210022 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.59599304 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.09599304 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.60800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.10800171 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.94999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.44999695 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.15400696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.65400696 58.52199936 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.68701172 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.18701172 58.52199936 Tm [(imm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(une)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.19799995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.69799995 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.86199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.36199951 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.16899872 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.66899872 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.76399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.26399994 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.48100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.98100281 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.66299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.16299438 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.34399414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.84399414 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.71000671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.21000671 74.12200165 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.2829895 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.7829895 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.85800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.35800171 74.12200165 Tm [(bin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.33200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.83200073 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.83300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.33300018 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.08100128 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.58100128 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.8030014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.3030014 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.32400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.82400513 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.82499695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.32499695 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.32200623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.82200623 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.09899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.59899902 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.67399597 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.17399597 89.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.96099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.46099854 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.61999512 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.11999512 89.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ell)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.06200027 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.56200027 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.8390007 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.3390007 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.22200012 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.29699707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.79699707 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10099792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.60099792 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.602005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.102005 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.94599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.44599915 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.25300598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.75300598 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.30801392 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.80801392 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.6499939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.1499939 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.15100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.65100098 105.3219986 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.69299984 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.19299984 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.77899933 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.27899933 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.84000015 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.34000015 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.48300171 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.98300171 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.49500275 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.99500275 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.55200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.05200195 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.94200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.44200134 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.71899414 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.21899414 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.22000122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.72000122 120.92199707 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.53601074 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.03601074 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.87799072 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.3730011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.8730011 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.81399918 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.31400299 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.83499908 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.33499908 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.21900177 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.71900177 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.04699707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.54699707 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.52200317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.02200317 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.55000305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05000305 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.33799744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.83799744 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.602005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.102005 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.66299438 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.16299438 136.52200317 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.80801392 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.30801392 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.38299561 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.88299561 136.52200317 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.71699905 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.21699905 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.95300293 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 47.54999924 l 107.17500305 47.54999924 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(00-10)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01699829 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.79499817 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03399658 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.272995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.772995 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.55099487 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92399597 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.19299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.69299316 11.72200012 Tm [(1/)-1(10)-1(0-10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.33399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.83399963 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.94999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.44999695 27.3220005 Tm [(1/)-1(10)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.41099548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.91099548 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.18899536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.68899536 27.3220005 Tm [(Immuno)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(fluoresce)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.27700043 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 0.75 m 106.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 157.5 m 106.80000305 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q q 1 0 0 1 0 481.02301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 508.96200562 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 536.90100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 564.84002686 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 592.7789917 cm Q Q 1 0 0 -1 0 841.90002441 cm
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