%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 77 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 79.5 l -90 79.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 68.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 228 0 0 -66.70000458 0 66.70000458 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 122.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [(Bi)1(ot)1(in)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 59.89799881 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 197.92599487 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.24000549 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 80.22699738 30.76399994 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 145.852005 30.76399994 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.06399536 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 87.07800293 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [(Bio)-1(tin)-1(-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.56900024 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.94299316 30.76399994 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.63400269 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.00799561 30.76399994 Tm [(anti)-1(-rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.90299988 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.2769928 30.76399994 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.48899841 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 132.95599365 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 30.76399994 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 47.25 30.76399994 Tm [<001000110012000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 144.375 30.76399994 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.58700562 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.83399963 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<001300140015000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 80.22699738 30.76399994 Tm [<0003000400160006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 122.22699738 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 48.43599701 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 66.64199829 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 66.64199829 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 66.64199829 Tm [<0018000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 66.64199829 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 66.64199829 Tm [<0019001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 66.64199829 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 66.64199829 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 66.64199829 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 84.31399536 Tm [( )] TJ ET EMC Q q 1 g -1.45000005 278.5289917 m 416.75 278.5289917 l 416.75 309.72900391 l -1.45000005 309.72900391 l h f* Q q 1 0 0 1 0 278.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 309.72900391 cm q 1 g 0.375 0.75 m 96.67500305 0.75 l 96.67500305 312.75 l 0.375 312.75 l h f* Q q -0.625 -0.25 m 97.67500305 -0.25 l 97.67500305 313.75 l -0.625 313.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 10 Tf 1 0 0 -1 0 160.35699463 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 10 Tf 1 0 0 -1 60.80099869 160.35699463 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 97.42500305 0.75 m 426.17498779 0.75 l 426.17498779 312.75 l 97.42500305 312.75 l h f* Q q 1 0 0 1 97.05000305 0 cm -0.625 -0.25 m 330.125 -0.25 l 330.125 313.75 l -0.625 313.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 10 Tf 1 0 0 -1 0 19.95700073 Tm 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.80999756 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.80999756 19.95700073 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.24700165 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.24700165 19.95700073 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.6989975 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.6989975 19.95700073 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.98899841 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.98899841 19.95700073 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.18200684 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.18200684 19.95700073 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.0059967 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.0059967 19.95700073 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.56300354 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.56300354 19.95700073 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64500427 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.64500427 19.95700073 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.69500732 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.69500732 19.95700073 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.10900879 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 51.1570015 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.82299995 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.82299995 51.1570015 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.47600174 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.47600174 51.1570015 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.91500092 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.91500092 51.1570015 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.81099701 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.81099701 51.1570015 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.35899353 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.35899353 51.1570015 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.55000305 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.55000305 51.1570015 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.46899414 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.46899414 51.1570015 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.00999451 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.01000977 51.1570015 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.83300781 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.83300781 51.1570015 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.30599976 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.30599976 51.1570015 Tm [(blo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 82.35700226 Tm [(od)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.16100025 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.1609993 82.35700226 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.93299866 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93299866 82.35700226 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.22299957 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.22299957 82.35700226 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.95700073 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.95700073 82.35700226 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.59999847 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.59999847 82.35700226 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.93800354 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.93800354 82.35700226 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.61399841 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.61399841 82.35700226 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.24299622 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24299622 82.35700226 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.01501465 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.01501465 82.35700226 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 113.55699921 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.55900002 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.55900002 113.55699921 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.11600113 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.11600113 113.55699921 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.31900024 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.31900024 113.55699921 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.33899689 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33899689 113.55699921 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.54499817 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.54499817 113.55699921 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.2250061 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.2250061 113.55699921 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.49899292 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.49899292 113.55699921 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.06100464 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.06100464 113.55699921 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.2170105 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.2170105 113.55699921 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.74398804 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.74398804 113.55699921 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.20199585 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.20199585 113.55699921 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.02600098 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 144.75700378 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.33799934 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.33799934 144.75700378 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.48500061 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.48500061 144.75700378 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.88400269 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.88400269 144.75700378 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.6210022 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.6210022 144.75700378 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.18400574 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.18400574 144.75700378 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.95599365 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.95599365 144.75700378 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.52999878 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.52999878 144.75700378 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84298706 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.84298706 144.75700378 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.82199097 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.82199097 144.75700378 Tm [(sep)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 175.95700073 Tm [(ara)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.27199936 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.27199936 175.95700073 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.01999664 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.01999664 175.95700073 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.10299683 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.10299683 175.95700073 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.70899963 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.70899963 175.95700073 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.79200745 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.79200745 175.95700073 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.34899902 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34899902 175.95700073 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.73599243 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.73599243 175.95700073 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.87199402 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.87199402 175.95700073 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.33999634 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.33999634 175.95700073 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.89700317 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.89700317 175.95700073 Tm [(respo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 207.15699768 Tm [(nse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.46500015 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.46500015 207.15699768 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.55099869 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.55099869 207.15699768 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.63399887 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.63399887 207.15699768 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.50800323 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.50800323 207.15699768 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.23999786 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.23999786 207.15699768 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.88000488 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.88000488 207.15699768 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.96600342 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.96600342 207.15699768 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.16900635 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.16900635 207.15699768 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.2519989 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.2519989 207.15699768 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.14599609 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.14599609 207.15699768 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.70300293 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.70300293 207.15699768 Tm [(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 238.35699463 Tm [(igen.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.3010006 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.3010006 238.35699463 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.86399841 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.86399841 238.35699463 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.03600311 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.03600311 238.35699463 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.86000061 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.86000061 238.35699463 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.41700745 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.41700745 238.35699463 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.18899536 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.18899536 238.35699463 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.95199585 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.95199585 238.35699463 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.24200439 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.24200439 238.35699463 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.28999329 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.28999329 238.35699463 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.97000122 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.97000122 238.35699463 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.25500488 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.25500488 238.35699463 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 269.55700684 Tm [(combinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.38600159 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.38600159 269.55700684 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.47200012 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47200012 269.55700684 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.02899933 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.02899933 269.55700684 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.602005 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.602005 269.55700684 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.42599487 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.42599487 269.55700684 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.28399658 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.28399658 269.55700684 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.10699463 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.10699463 269.55700684 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.79600525 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.79598999 269.55700684 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.33401489 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.33401489 269.55700684 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.58700562 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 300.75698853 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.52699995 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.52700043 300.75698853 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.66999817 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.66999817 300.75698853 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.10100174 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.10099792 300.75698853 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.39399719 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.39399719 300.75698853 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.68399811 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.68399811 300.75698853 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.06700134 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.06700134 300.75698853 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.1499939 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.1499939 300.75698853 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.21099854 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.21099854 300.75698853 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.66799927 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.66799927 300.75698853 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.375 300.75698853 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 312.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.05000305 0.75 m 97.05000305 312.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 312.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 313.125 m 426.92498779 313.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>