%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 83 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 82.5 l -90 82.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 71.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 239.25 0 0 -70 0 70 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 125.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [(Bi)1(ot)1(in)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 59.89799881 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 220.01400757 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.32800293 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 30.76399994 Tm [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.47699738 30.76399994 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 161.602005 30.76399994 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.81399536 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 87.07800293 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [(Bio)-1(tin)-1(-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.56900024 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.94299316 30.76399994 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.65100098 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.0249939 30.76399994 Tm [(anti)-1(-rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.91999817 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.29400635 30.76399994 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.5059967 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 132.95599365 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 30.76399994 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 30.76399994 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 30.76399994 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 30.76399994 Tm [<0011001200130003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.125 30.76399994 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.33700562 30.76399994 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 178.83399963 m 416.75 178.83399963 l 416.75 196.83399963 l -1.45000005 196.83399963 l h f* Q q 1 0 0 1 0 178.83399963 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 15.04699993 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 196.83399963 m 416.75 196.83399963 l 416.75 214.83399963 l -1.45000005 214.83399963 l h f* Q q 1 g -1.45000005 214.83399963 m 416.75 214.83399963 l 416.75 232.83399963 l -1.45000005 232.83399963 l h f* Q q 1 g -1.45000005 232.83399963 m 416.75 232.83399963 l 416.75 250.83399963 l -1.45000005 250.83399963 l h f* Q q 1 g -1.45000005 250.83399963 m 416.75 250.83399963 l 416.75 282.03399658 l -1.45000005 282.03399658 l h f* Q q 1 0 0 1 0 196.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 15.04699993 Tm 0 g [<0014001500160010000E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 15.04699993 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 15.04699993 Tm [(Biotin)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.875 15.04699993 Tm [<00030004001C0007>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 133.875 15.04699993 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 15.04699993 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 33.04700089 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 51.04700089 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 10.5 51.04700089 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 51.04700089 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 47.25 51.04700089 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 57.75 51.04700089 Tm [<001F00200021>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 89.25 51.04700089 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105 51.04700089 Tm [<00250026>] TJ ET EMC /P <> BDC BT /FAAACG 18 Tf 1 0 0 -1 126 51.04700089 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC /P <> BDC q /GS3 gs 1 g 0 60.59400177 m 42 60.59400177 l 42 78.60500336 l 0 78.60500336 l h f* Q EMC /P <> BDC BT /FAAADA 10.5 Tf 1 0 0 -1 0 74.17500305 Tm 0 Tr /GS3 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAADE 10.5 Tf 1 0 0 -1 42 74.17500305 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 282.03399658 cm q 1 g 0.375 0.75 m 124.375 0.75 l 124.375 343.95001221 l 0.375 343.95001221 l h f* Q q -0.625 -0.25 m 125.375 -0.25 l 125.375 344.95001221 l -0.625 344.95001221 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADE 10 Tf 1 0 0 -1 0 175.95700073 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADI 10 Tf 1 0 0 -1 60.80099869 175.95700073 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 125.125 0.75 m 426.17498779 0.75 l 426.17498779 343.95001221 l 125.125 343.95001221 l h f* Q q 1 0 0 1 124.75 0 cm -0.625 -0.25 m 302.42498779 -0.25 l 302.42498779 344.95001221 l -0.625 344.95001221 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADI 10 Tf 1 0 0 -1 0 19.95700073 Tm 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.80999756 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.80999756 19.95700073 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.24700165 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.24700165 19.95700073 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.6989975 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.6989975 19.95700073 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.98899841 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.98899841 19.95700073 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.18200684 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.18200684 19.95700073 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.0059967 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.0059967 19.95700073 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.56300354 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.56300354 19.95700073 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64500427 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.64500427 19.95700073 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.69500732 19.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.69500732 19.95700073 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 51.1570015 Tm [(teins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.85199928 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.85199928 51.1570015 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.67499924 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.67499924 51.1570015 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.32800293 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32800293 51.1570015 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.76699829 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.76699829 51.1570015 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.66299438 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.66299438 51.1570015 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.21099854 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.21099854 51.1570015 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.4019928 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.4019928 51.1570015 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.32099915 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.32099915 51.1570015 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.86199951 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.86199951 51.1570015 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.68499756 51.1570015 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 82.35700226 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.47299957 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.47299957 82.35700226 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.03900146 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.03900146 82.35700226 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.81099701 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.81099701 82.35700226 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.10099792 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.10099792 82.35700226 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83500671 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.83500671 82.35700226 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.47799683 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.47799683 82.35700226 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.81599426 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.81599426 82.35700226 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.49200439 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.49200439 82.35700226 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.1210022 82.35700226 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.1210022 82.35700226 Tm [(mic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 113.55699921 Tm [(roo)1(rganisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.72700119 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72699738 113.55699921 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81300354 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.81300354 113.55699921 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.37000275 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.37000275 113.55699921 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.57299805 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.57299805 113.55699921 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.59300232 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.59300232 113.55699921 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.79899597 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.79899597 113.55699921 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.47900391 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.47900391 113.55699921 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.75300598 113.55699921 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.75299072 113.55699921 Tm [(lymph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 144.75700378 Tm [(ocy)-1(t)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.69300079 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.69300079 144.75700378 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.84899902 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.84899902 144.75700378 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.37599945 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.37599945 144.75700378 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.83399963 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.83399963 144.75700378 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.65799713 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.65799713 144.75700378 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.9960022 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.9960022 144.75700378 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.14300537 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.14300537 144.75700378 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.54200745 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.54200745 144.75700378 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.2789917 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.2789917 144.75700378 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.8420105 144.75700378 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.8420105 144.75700378 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 175.95700073 Tm [(gG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.83300018 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.83300018 175.95700073 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.4070015 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.40699768 175.95700073 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.72000122 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.72000122 175.95700073 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.6989975 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.6989975 175.95700073 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.66099548 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.66099548 175.95700073 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.40899658 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.40899658 175.95700073 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.49200439 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.49200439 175.95700073 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.0980072 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.0980072 175.95700073 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.18099976 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.18099976 175.95700073 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.73800659 175.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.73800659 175.95700073 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 207.15699768 Tm [(at)1(hog)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45 207.15699768 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.13600159 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.13600159 207.15699768 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.60399628 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.60399628 207.15699768 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.16100311 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.16099548 207.15699768 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.49099731 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.49099731 207.15699768 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.57699585 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.57699585 207.15699768 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.66000366 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.66000366 207.15699768 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.53399658 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.53399658 207.15699768 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.26599121 207.15699768 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.26599121 207.15699768 Tm [(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 238.35699463 Tm [(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.95100021 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.95100021 238.35699463 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.03699875 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.03699875 238.35699463 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.23999786 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.23999786 238.35699463 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32299805 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.32299805 238.35699463 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.21699524 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.21699524 238.35699463 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.77400208 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.77400208 238.35699463 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.49000549 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.49000549 238.35699463 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.05299377 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.05299377 238.35699463 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.2250061 238.35699463 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.2250061 238.35699463 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 269.55700684 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.46700001 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.46700001 269.55700684 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02400017 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.02400017 269.55700684 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.79600143 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.79600143 269.55700684 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.55899811 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.55899811 269.55700684 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.84899902 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84899902 269.55700684 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.89700317 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.89700317 269.55700684 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.57699585 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.57699585 269.55700684 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.86199951 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.86199951 269.55700684 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.73999023 269.55700684 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.73999023 269.55700684 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 300.75698853 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.39599991 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.39599991 300.75698853 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.95299911 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.95299911 300.75698853 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.52600098 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.52600098 300.75698853 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.34999847 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.34999847 300.75698853 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.20799255 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.20799255 300.75698853 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.03100586 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.03100586 300.75698853 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.72000122 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.72000122 300.75698853 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.25799561 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.25799561 300.75698853 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.51100159 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.51100159 300.75698853 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.03799438 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.03799438 300.75698853 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.18099976 300.75698853 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.18099976 300.75698853 Tm [(ti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 331.95700073 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.04399967 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.04400063 331.95700073 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.3370018 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.3370018 331.95700073 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.6269989 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.6269989 331.95700073 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.01000214 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.01000214 331.95700073 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.09300232 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.09300232 331.95700073 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.15400696 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.15400696 331.95700073 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.61099243 331.95700073 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.61099243 331.95700073 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.31799316 331.95700073 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 343.95001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.75 0.75 m 124.75 343.95001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 343.95001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 344.32501221 m 426.92498779 344.32501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| 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