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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 47.35100174 23.67700005 Tm 0 g [(FIT)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 74.20600128 23.67700005 Tm [(C)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 91.35099792 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 185.20300293 23.67700005 Tm 0 Tr [(GAPD)-1(H)] TJ ET EMC /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 257.50900269 23.67700005 Tm 2 Tr [<0007>-4<0008>-4<0009>-4<0006>-4<000A>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 367.94900513 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 41.20000076 cm /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 69.13899994 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(FIT)-1(C)] TJ ET EMC /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.80999756 12.82499981 Tm [<0003000400050006>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 128.43499756 12.82499981 Tm [(GA)1(PDH)] TJ ET EMC /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 162.18600464 12.82499981 Tm [<0007000800090006000A>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 214.68600464 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 219.93600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 102.6780014 cm /P <</Lang (zh-CN) /MCID 15 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 16 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FIT)-1(C-con)-1(jugated)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 132.1519928 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 134.52600098 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 162.21699524 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 164.59100342 12.82499981 Tm [(anti)-1(-GA)1(PDH)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 215.40400696 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 217.77799988 12.82499981 Tm [(pl)-1(oyclo)-1(nal)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 261.33700562 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 263.71099854 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 301.50698853 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 136.21699524 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130014000F>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AP)] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 77.125 12.82499981 Tm [<0003000400150006>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 119.125 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 124.375 12.82499981 Tm [<00160006>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 145.375 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 169.7559967 cm /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018000F>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0019001A001B>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001E001F>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 203.29499817 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000F>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000F>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 270.37298584 cm /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000F>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FIT)-1(C)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 81.18499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 303.9119873 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0008000900130027000F>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 337.45098877 cm /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0028000F>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FIT)-1(C-con)-1(jugated)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 132.1519928 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 134.52600098 12.82499981 Tm [(GA)1(PDH)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 165.6519928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 370.98999023 m 416.75 370.98999023 l 416.75 402.19000244 l -1.45000005 402.19000244 l h f* Q q 1 0 0 1 0 370.98999023 cm /P <</MCID 79 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.19000244 cm /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 430.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(FC)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 11.08300018 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 15.58300018 11.72200012 Tm [(Recommend)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 72.39499664 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 76.89499664 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 114.74099731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 129.67500305 16.35000038 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(20)-1(-)1(1)-1(00)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 30.28300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 128.92500305 0.75 l 128.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 129.92500305 -0.25 l 129.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 129.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 129.67500305 172.3500061 l h f* Q q 1 0 0 1 129.30000305 0 cm -0.625 -0.25 m 294.125 -0.25 l 294.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(ab)1(u)-1(nd)1(anc)-1(e)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 68.01799774 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 72.51799774 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 81.36000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 85.86000061 11.72200012 Tm [(glyc)-1(era)1(l)-1(d)1(e)-1(h)1(y)-1(d)1(e)-1(-)1(3)-1(-)1(pho)1(spha)1(te)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 210.19900513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 214.69900513 11.72200012 Tm [(dehydro)1(gen)-1(a)1(se)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 281.43899536 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 57.15100098 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 61.65100098 27.3220005 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 80.22699738 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 84.72699738 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 91.28800201 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 95.78800201 27.3220005 Tm [(relatively)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 134.43800354 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 138.93800354 27.3220005 Tm [(unaffected)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 185.08099365 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 189.58099365 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 200.09300232 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 204.59300232 27.3220005 Tm [(eternal)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 234.51100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 239.01100159 27.3220005 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 270.4630127 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 274.9630127 27.3220005 Tm [(In)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 283.1539917 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(west)1(e)-1(rn)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 33.81999969 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 38.31999969 42.92200089 Tm [(blot)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 55.5379982 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 60.0379982 42.92200089 Tm [(analysis)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 93.41899872 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 97.91899872 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 111.91999817 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 116.41999817 42.92200089 Tm [(leve)-1(l)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 136.14700317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 140.64700317 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 149.48899841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 153.98899841 42.92200089 Tm [(GA)1(PDH,)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 188.5039978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 193.0039978 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 197.97900391 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 202.47900391 42.92200089 Tm [(38)-1(kDa)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 229.76499939 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 234.26499939 42.92200089 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 267.73800659 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 272.23800659 42.92200089 Tm [(ca)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(be)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 20.89999962 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 25.39999962 58.52199936 Tm [(used)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 45.97499847 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 50.47499847 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 59.61600113 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 64.11599731 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 69.09100342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 73.59100342 58.52199936 Tm [(refere)-1(nce)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 114.06900024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 118.56900024 58.52199936 Tm [(value)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 141.31500244 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 145.81500244 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 158.09300232 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 162.59300232 58.52199936 Tm [(load)1(in)-1(g)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 195.13900757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 199.63900757 58.52199936 Tm [(control.)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 232.49299622 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 236.99299622 58.52199936 Tm [(Has)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 253.09500122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 257.59500122 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 277.95901489 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(glyc)-1(era)1(l)-1(d)1(e)-1(h)1(y)-1(d)1(e)-1(-)1(3)-1(-)1(pho)1(spha)1(te)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 124.33899689 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 128.83900452 74.12200165 Tm [(dehydro)1(gen)-1(a)1(se)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 195.57899475 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 200.07899475 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 216.35600281 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 220.85600281 74.12200165 Tm [(nitro)1(sy)-1(la)1(se)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 266.88000488 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 271.38000488 74.12200165 Tm [(act)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ivities,)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 26.70100021 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 31.20100021 89.72200012 Tm [(th)1(e)-1(reby)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 64.25700378 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 68.75700378 89.72200012 Tm [(playing)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 100.33599854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 104.83599854 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 109.81099701 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 114.31099701 89.72200012 Tm [(role)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 130.97099304 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 135.47099304 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 143.41200256 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 147.91200256 89.72200012 Tm [(glyc)-1(o)1(ly)-1(sis)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 188.94799805 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 193.44799805 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 209.7250061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 214.2250061 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 245.74299622 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 250.24299622 89.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s,)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 6.33300018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 10.83300018 105.3219986 Tm [(respec)-1(t)1(ive)-1(ly.)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 63.81299973 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 68.31300354 105.3219986 Tm [(Par)1(tic)-1(ip)1(ates)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 118.23500061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 122.73500061 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 130.67599487 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 135.17599487 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 166.69400024 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 171.19400024 105.3219986 Tm [(eve)-1(nt)1(s)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 199.19599915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 203.69599915 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 243.54600525 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 248.04600525 105.3219986 Tm [(tr)1(ansc)-1(rip)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tio)1(n)-1(,)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 19.18199921 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 23.68199921 120.92199707 Tm [(RNA)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 43.20700073 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 47.70700073 120.92199707 Tm [(tr)1(anspor)1(t,)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 89.60900116 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 94.10900116 120.92199707 Tm [(DNA)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 114.61399841 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 119.11399841 120.92199707 Tm [(replic)-1(a)1(tion)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 164.69799805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 169.19799805 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 185.4750061 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 189.9750061 120.92199707 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 234.13600159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 238.63600159 120.92199707 Tm [(Nuc)-1(lear)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 271.92498779 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 276.42498779 120.92199707 Tm [(fu)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nc)-1(t)1(ions)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 31.24099922 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 35.74100113 136.52200317 Tm [(are)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 49.25899887 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 53.75899887 136.52200317 Tm [(pro)1(bab)1(ly)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 92.29499817 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 96.79499817 136.52200317 Tm [(due)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 113.20400238 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 117.70400238 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 126.77899933 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 131.27900696 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 145.27999878 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 149.77999878 136.52200317 Tm [(nitro)1(sy)-1(la)1(se)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 195.80400085 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 200.30400085 136.52200317 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 230.77600098 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 235.27600098 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 252.4980011 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 256.99798584 136.52200317 Tm [(media)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(tes)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 12.625 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 17.125 152.12199402 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 52.07500076 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 56.57500076 152.12199402 Tm [(S-nitr)1(osyl)-1(a)1(tion)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 119.43000031 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 123.93000031 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 132.77200317 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 137.27200317 152.12199402 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 168.78999329 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 173.28999329 152.12199402 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 199.27000427 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 203.77000427 152.12199402 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 239.24299622 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 243.74299622 152.12199402 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 263.51000977 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 268.01000977 152.12199402 Tm [(as)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 277.15100098 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(SIRT1)-1(,)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 26.31900024 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 30.81900024 167.72200012 Tm [(HDAC2)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 62.26599884 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 66.76599884 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 83.04299927 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 87.54299927 167.72200012 Tm [(PRK)1(DC)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 117.51399994 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 122.01399994 167.72200012 Tm [(By)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 132.42500305 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 136.92500305 167.72200012 Tm [(similarit)1(y)-1(.)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 177.79899597 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 182.29899597 167.72200012 Tm [(Glyc)-1(era)1(l)-1(d)1(e)-1(h)1(y)-1(d)1(e)-1(-)1(3)-1(-)1(pho)1(s)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 0.75 m 129.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.30000305 17.10000038 m 129.30000305 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07501221 m 423.17498779 189.07501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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