%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.31600189 23.67700005 Tm 0 g [(GNL3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.27900696 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.27900696 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.98300171 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(GN)1(L)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.13800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.38800049 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.38800049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GN)1(L)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.13800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.51200104 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.71399689 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.08799744 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.06799316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.44200134 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.91600037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(guani)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.15599823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.52999878 12.82499981 Tm [(nu)-1(cleotid)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.84199524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.21600342 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.04400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.41799927 12.82499981 Tm [(protein)-1(-li)-1(k)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.83200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.20599365 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.33700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.71099854 12.82499981 Tm [(NS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.12298584 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.49700928 12.82499981 Tm [(E2IG3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.34698486 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.7210083 12.82499981 Tm [(NN)1(P4)1(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.1539917 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.52801514 12.82499981 Tm [(C77032)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.73599243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(282-4)1(56)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(GN)1(L)-1(3)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 391.57400513 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.375 16.35000038 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(guanine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.87099838 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.37099838 11.72200012 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.80999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.30999756 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.45400238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.95400238 11.72200012 Tm [(pro)1(tein)-1(-)1(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.95100403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.45100403 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.72900391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.375 16.35000038 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.67800045 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.1779995 11.72200012 Tm [(E2IG3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.18700027 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.68700027 11.72200012 Tm [(NNP47)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.5490036 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.0490036 11.72200012 Tm [(C77)-1(03)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.45899963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.375 16.35000038 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(VP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.13000107 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.375 16.35000038 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(02)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 155.375 31.95000076 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.375 16.35000038 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.375 16.35000038 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.625 0.75 l 154.625 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 155.625 -0.25 l 155.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.375 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 155.375 94.34999847 l h f* Q q 1 0 0 1 155 0 cm -0.625 -0.25 m 272.17498779 -0.25 l 272.17498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.77600098 11.72200012 Tm [(interact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.45399475 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.95399475 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.3500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.8500061 11.72200012 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.1539917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.94800186 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.44800186 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.30199814 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.80199814 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.17099762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.67099762 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.61199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.11199951 27.3220005 Tm [(tumor)1(ige)-1(nesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.40600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.90600586 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.21299744 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.72000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.22000122 27.3220005 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 42.92200089 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.80400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.30400085 42.92200089 Tm [(ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.45800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.95800018 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.03299713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.53299713 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.38700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.88700104 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.8480072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.3480072 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.62600708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.12600708 42.92200089 Tm [(st)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.18499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.68499756 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.09500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.59500122 42.92200089 Tm [(pro)1(life)-1(r)1(atio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.71199989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.21199989 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.47400093 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.97399902 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.28099823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.78099823 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.34200287 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.84200287 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.53199768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.03199768 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.97299957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.47299957 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.83700562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.33700562 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.33799744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.83799744 58.52199936 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.65600586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.15600586 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.43299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.93299866 58.52199936 Tm [(nuc)-1(leolu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 74.12200165 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.18299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.68299866 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.60500336 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.10500336 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.67500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.17500305 74.12200165 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.51699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.01699829 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.19799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.69799805 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.63800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.13800049 74.12200165 Tm [(isof)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.01300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.51300049 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.02000046 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.52000046 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.20999908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.70999908 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.98799896 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.48799896 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.94400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.44400024 89.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.12600708 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 0.75 m 155 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 17.10000038 m 155 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 33.45000076 m 155 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 49.80000305 m 155 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 66.15000153 m 155 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 98.1000061 m 155 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 114.45000458 m 155 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155 130.80000305 m 155 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>