%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 78 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 105.60399628 23.67700005 Tm 0 g [(AP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 136.14399719 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 274.17199707 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.6960144 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 69.13899994 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(AP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 77.125 12.82499981 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 142.75 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.31500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68899536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 102.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AP)1(-co)-1(nju)-1(g)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.46700287 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.84100342 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.53199768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.90600586 12.82499981 Tm [(anti)-1(-hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.56100464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.93499756 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 136.21699524 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 77.125 12.82499981 Tm [<0003000400130007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 119.125 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 169.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 203.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 236.83399963 m 416.75 236.83399963 l 416.75 268.03399658 l -1.45000005 268.03399658 l h f* Q q 1 0 0 1 0 236.83399963 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 268.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 295.97299194 cm q /GS2 gs 1 g 0.375 0.75 m 87.67500305 0.75 l 87.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 88.67500305 -0.25 l 88.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 88.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 88.42500305 156.75 l h f* Q q 1 0 0 1 88.05000305 0 cm -0.625 -0.25 m 335.375 -0.25 l 335.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 11.72200012 Tm [(normally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86199951 11.72200012 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 11.72200012 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42399597 11.72200012 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.48599243 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82800293 11.72200012 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01600647 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.42700195 11.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.62298584 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.12298584 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ntibo)1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.2840004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.7840004 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.34500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.84500122 27.3220005 Tm [(pro)1(min)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.1309967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.6309967 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.5719986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.0719986 27.3220005 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.7480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.2480011 27.3220005 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.70700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.20700073 27.3220005 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.86999512 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.94500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.44500732 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.11898804 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.61898804 27.3220005 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.4630127 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.9630127 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.23999023 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 42.92200089 Tm [(larg)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.88899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.38899994 42.92200089 Tm [(confine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.09400177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.59400177 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.66899872 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.16899872 42.92200089 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.86000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.36000061 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.76899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.26899719 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.34399414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.84399414 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.75799561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.25799561 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.92700195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.42700195 42.92200089 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.68600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.18600464 42.92200089 Tm [(Monomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.85299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.35299683 42.92200089 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.54901123 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.04901123 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.60998535 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.10998535 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(xpr)1(e)-1(ssed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.04800034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.54800034 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.68899918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18899918 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.16400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.66400146 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.44799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.94799805 58.52199936 Tm [(bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.26600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.76600647 58.52199936 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.0249939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.5249939 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.79299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.29299927 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.29400635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.79400635 58.52199936 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.65701294 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.15701294 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.99899292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.49899292 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.14599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.64599609 58.52199936 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.22198486 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.72198486 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.99899292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.61599922 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.11599922 74.12200165 Tm [(pentamer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.81999969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.31999969 74.12200165 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.62000275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.12000275 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.66499329 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.16499329 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.17700195 74.12200165 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.86799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.36799622 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.11000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.61000061 74.12200165 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.61799622 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.69299316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.19299316 74.12200165 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.10699463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.60699463 74.12200165 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.8420105 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.3420105 74.12200165 Tm [(valenc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.36499023 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.86499023 74.12200165 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(gM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55000019 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.04999924 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.61100006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.11100006 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.80899811 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.30899811 89.72200012 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.96399689 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.46399689 89.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.8789978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.3789978 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.53799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.03799438 89.72200012 Tm [(isot)1(y)-1(p)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.45799255 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.95799255 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.51899719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.01899719 89.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.16299438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.66299438 89.72200012 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.50698853 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.00698853 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.40301514 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.90301514 89.72200012 Tm [(repea)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.0510006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.5510006 105.3219986 Tm [(epito)1(pe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.89599991 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.39599991 105.3219986 Tm [(\(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.66899872 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.16899872 105.3219986 Tm [(pa)1(rticle)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.25700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.75700378 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.03399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.53399658 105.3219986 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.83399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.33399963 105.3219986 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.67700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.17700195 105.3219986 Tm [(ce)-1(lls\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.75900269 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.25900269 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.53599548 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.03599548 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.59700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.09698486 105.3219986 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.79501343 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.29501343 105.3219986 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.95001221 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.41500092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.91500092 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.00999832 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.50999832 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.45100021 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.95100021 120.92199707 Tm [(activiat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.33100128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.83100128 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.83200073 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.33200073 120.92199707 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.68800354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.18800354 120.92199707 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.81599426 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.31599426 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.1230011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.6230011 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.13900757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.63900757 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.91699219 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.41699219 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.41799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.91799927 120.92199707 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.89700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(constant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.17300034 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.67300034 136.52200317 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.63500214 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.13500214 136.52200317 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.34999847 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.84999847 136.52200317 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.67399597 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.17399597 136.52200317 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.16700745 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.66700745 136.52200317 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.28999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.78999329 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.30200195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.80200195 136.52200317 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.02099609 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.52099609 136.52200317 Tm [(interven)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.43200684 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.93200684 136.52200317 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(eque)-1(nce)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.01399994 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 87.67500305 0.75 l 87.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 88.67500305 -0.25 l 88.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 88.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 88.42500305 31.95000076 l h f* Q q 1 0 0 1 88.05000305 0 cm -0.625 -0.25 m 335.375 -0.25 l 335.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(00-10)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01699829 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.79499817 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03399658 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.272995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.772995 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.55099487 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92399597 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.19299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.69299316 11.72200012 Tm [(1/)-1(20)-1(0-500)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.37701416 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.87701416 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.15499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.11599731 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 88.05000305 0.75 m 88.05000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 88.05000305 157.5 m 88.05000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 541.30102539 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>