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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.55999756 23.67700005 Tm 0 g [(AP)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 125.09999847 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 285.21600342 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.73999023 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 41.20000076 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 69.13899994 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(AP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 66.625 12.82499981 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 142.75 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.31500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68899536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 102.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(AP)1(-co)-1(nju)-1(g)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.96700287 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.34100342 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.04899597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.42300415 12.82499981 Tm [(anti)-1(-hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.07800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.45199585 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.01699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 136.21699524 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(AP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 66.625 12.82499981 Tm [<0003000400140008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.625 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 169.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 203.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 236.83399963 m 416.75 236.83399963 l 416.75 268.03399658 l -1.45000005 268.03399658 l h f* Q q 1 0 0 1 0 236.83399963 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 268.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 295.97299194 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 98.17500305 156.75 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 325.625 -0.25 l 325.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 11.72200012 Tm [(normally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.86199951 11.72200012 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 11.72200012 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42399597 11.72200012 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.48599243 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82800293 11.72200012 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01600647 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.42700195 11.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.62298584 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.25899887 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.75899887 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.31999969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.81999969 27.3220005 Tm [(pro)1(min)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.10600281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.60600281 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.54699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.04699707 27.3220005 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.7230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.2230072 27.3220005 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.68200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.18200684 27.3220005 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.34500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.84500122 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.91999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.41999817 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.09399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.59399414 27.3220005 Tm [(antig)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.43798828 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.93798828 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.36400032 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.86400032 42.92200089 Tm [(larg)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.69200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.19200134 42.92200089 Tm [(confine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.89700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.39700317 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.47200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.97200012 42.92200089 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.66299438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.16299438 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.57200623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.07200623 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.14700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.64700317 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.56100464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.06100464 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.72999573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.22999573 42.92200089 Tm [(size.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.48899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.98899841 42.92200089 Tm [(Monomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.65600586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.15600586 42.92200089 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.79300022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.29300022 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.85400009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.35400009 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50800323 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.00800323 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.14900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.64900208 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.62400055 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.12400055 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.90800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.40800476 58.52199936 Tm [(bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.72599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.22599792 58.52199936 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.48500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.98500061 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.25300598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.75300598 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.7539978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.2539978 58.52199936 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.11700439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.61700439 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.45901489 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.95901489 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.60598755 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.57600021 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.07600021 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.35300064 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.85300064 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.99399948 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.49399948 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.46900177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.96900177 74.12200165 Tm [(pentamer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.67299652 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.17299652 74.12200165 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.4730072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.9730072 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.51800537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.01800537 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.52999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.02999878 74.12200165 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.72099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.22099304 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.96299744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.4630127 74.12200165 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.9710083 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.4710083 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.54598999 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.04598999 74.12200165 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.95999146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.45999146 74.12200165 Tm [(hi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(gh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29800034 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79800034 89.72200012 Tm [(valenc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.82099915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.32099915 89.72200012 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.51699829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.01699829 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.57800293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.07800293 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.77600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.27600098 89.72200012 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.93099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.43099976 89.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.84599304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.34599304 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.50500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.00500488 89.72200012 Tm [(isot)1(y)-1(p)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.42500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.92500305 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.48599243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.98599243 89.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.13000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.63000488 89.72200012 Tm [(antig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(en)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.81799984 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.31800079 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.7140007 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.2140007 105.3219986 Tm [(repeating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.63700104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.13700104 105.3219986 Tm [(epito)1(pe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.48200226 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.98199463 105.3219986 Tm [(\(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.25500488 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.75500488 105.3219986 Tm [(pa)1(rticle)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84300232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.34300232 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.61999512 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.11999512 105.3219986 Tm [(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.41999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.91999817 105.3219986 Tm [(bloo)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.26300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.76300049 105.3219986 Tm [(ce)-1(lls\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.34500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.84500122 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.12200928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.62200928 105.3219986 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 120.92199707 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.36400032 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.86399841 120.92199707 Tm [(efficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.51899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.01899719 120.92199707 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.43399811 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.93399811 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.02899933 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.52899933 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.47000122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.97000122 120.92199707 Tm [(activiat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.3500061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.8500061 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.85099792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.35099792 120.92199707 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.70700073 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.20700073 120.92199707 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.83499146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.33499146 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.14199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.29399872 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.79399872 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 136.52200317 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.27400208 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.77400208 136.52200317 Tm [(constant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.9469986 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.4469986 136.52200317 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.40899658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90899658 136.52200317 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.12399292 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.62399292 136.52200317 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.44799805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.94799805 136.52200317 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.94099426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.44100952 136.52200317 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.06399536 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.56399536 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.07598877 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.21899986 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.71899986 152.12199402 Tm [(interven)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.62999725 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.12999725 152.12199402 Tm [(seque)-1(nce)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.30999756 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 98.17500305 31.95000076 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 325.625 -0.25 l 325.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(20)-1(00-10)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01699829 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.79499817 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03399658 11.72200012 Tm [(1/)-1(10)-1(00-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.272995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.772995 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.55099487 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92399597 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.19299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.69299316 11.72200012 Tm [(1/)-1(20)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.6539917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.77799988 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry/)-1(cytochemistry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.89399719 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 0.75 m 97.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 157.5 m 97.80000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 541.30102539 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 569.23999023 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 597.17901611 cm Q Q 1 0 0 -1 0 841.90002441 cm
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