%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 155 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.83799744 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 160.602005 23.67700005 Tm 0 Tr [(TUB)1(B)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.02099609 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 326.46099854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TUBB)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 123.02600098 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.52600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.77600098 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TUB)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.01000214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.38400269 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.15600586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.52999878 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.85099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.2250061 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.02099609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Tu)-1(bul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.0019989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.37599945 12.82499981 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.66400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.03800201 12.82499981 Tm [(chai)-1(n;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.75999451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.13400269 12.82499981 Tm [(TUBB5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.73199463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.27600098 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 176.17500305 63.15000153 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tubuli)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.33499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.83499908 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.39599991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.89599991 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.89699936 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.39700317 11.72200012 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.36699677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.86699677 11.72200012 Tm [(constituent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.96600342 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.30799866 11.72200012 Tm [(mic)-1(r)1(otubules.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.83399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.33399963 11.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.33299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.61199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.11199951 27.3220005 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.29299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.79299927 27.3220005 Tm [(moles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.61499786 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.11499786 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.95700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.45700073 27.3220005 Tm [(GTP,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.98200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.48200226 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.85600281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.35600281 27.3220005 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.68400574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.18400574 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.70500183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.20500183 27.3220005 Tm [(exc)-1(h)1(angeable)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.53599548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.03599548 27.3220005 Tm [(sit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.87400055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.37400055 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.375 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.875 42.92200089 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.05699921 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.55699921 42.92200089 Tm [(chain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.52700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.02700043 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.30400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.80400085 42.92200089 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.17799377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.67799377 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.5059967 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.48100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.98100281 42.92200089 Tm [(non-exchangeable)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.01899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02099991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52099991 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.78899956 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.28900146 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.29000092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.79000092 58.52199936 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.4240036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.9240036 58.52199936 Tm [(chain.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.06099701 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TUBB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.17200089 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TUBB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.51800537 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tubuli)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.33499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.83499908 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51699829 11.72200012 Tm [(chain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.48699951 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TUBB)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.45000076 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P07)-1(43)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 161.25 cm q /GS2 gs 1 g 0.375 0.75 m 175.42500305 0.75 l 175.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.42500305 -0.25 l 176.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.17500305 16.35000038 l h f* Q q 1 0 0 1 175.80000305 0 cm -0.625 -0.25 m 247.625 -0.25 l 247.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.45999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.95999908 11.72200012 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9280014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.4280014 11.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.51799774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01799774 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.79499817 11.72200012 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.25500488 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.75500488 11.72200012 Tm [(live)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.81199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.31199646 11.72200012 Tm [(canc)-1(er;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.56799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.06799316 11.72200012 Tm [(Hu)-1(m)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 0.75 m 175.80000305 63.15000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 63.90000153 m 175.80000305 79.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 80.25 m 175.80000305 95.84999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 96.59999847 m 175.80000305 112.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 112.94999695 m 175.80000305 128.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 129.30000305 m 175.80000305 144.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 145.65000916 m 175.80000305 161.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.80000305 162.00001526 m 175.80000305 177.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 177.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 112.57499695 m 422.42498779 112.57499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.92500305 m 422.42498779 128.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 145.27500916 m 422.42498779 145.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 161.62501526 m 422.42498779 161.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.97502136 m 423.17498779 177.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>