%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 156 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.26300049 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 155.0269928 23.67700005 Tm 0 Tr [(TUB)1(B3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 221.59599304 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 332.03601074 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TUBB3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.3480072 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.8480072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.0980072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TUB)1(B3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.33200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.70600128 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.47799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.852005 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.17300415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.54699707 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.34300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tub)-1(ul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.40299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.91799927 12.82499981 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.20600128 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.72100067 12.82499981 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.04299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.55799866 12.82499981 Tm [(class)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.65100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.16600037 12.82499981 Tm [(III;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.91200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.42700195 12.82499981 Tm [(CDC)-1(BM;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.58299255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.0980072 12.82499981 Tm [(FE)-1(OM3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.11000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.625 12.82499981 Tm [(TUBB4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.0329895 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.54800415 12.82499981 Tm [(CDC)-1(BM1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.0249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.54000854 12.82499981 Tm [(CF)-1(EOM3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 379.15100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.66598511 12.82499981 Tm [(beta-4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(CF)-1(EOM3A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.8769989 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.59799957 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 171.67500305 0.75 l 171.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 172.67500305 -0.25 l 172.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 172.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 172.42500305 156.75 l h f* Q q 1 0 0 1 172.05000305 0 cm -0.625 -0.25 m 251.375 -0.25 l 251.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.88500214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.38500214 11.72200012 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.32200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.82200623 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.08599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.58599854 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.42799377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.92799377 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.92900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.42900085 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.61099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11099243 11.72200012 Tm [(tu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(bulin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.62999916 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.12999916 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.43700027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.93700027 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.18499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.68499756 27.3220005 Tm [(Be)-1(t)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.76599884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.26599884 27.3220005 Tm [(tub)1(u)-1(lins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.96099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.46099854 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.97900391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.47900391 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.85299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.35299683 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.19500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.69500732 27.3220005 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.87600708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.37600708 27.3220005 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.34999847 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.84999847 42.92200089 Tm [(fa)1(mi)-1(lies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.83499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.33499908 42.92200089 Tm [(\(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.97499847 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47499847 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.7519989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.2519989 42.92200089 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.43400574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.93400574 42.92200089 Tm [(tub)1(u)-1(lins\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.63499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.13499451 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.35699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.85699463 42.92200089 Tm [(het)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(erodimerize)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.31900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.81900024 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.09600067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.59600067 58.52199936 Tm [(assemble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.69200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.19200134 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.26699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.76699829 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.47799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.97799683 58.52199936 Tm [(mic)-1(r)1(otubules.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.5039978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.0039978 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.26600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.36800003 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.86800003 74.12200165 Tm [(prima)1(rily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.84600067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.34600067 74.12200165 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.5 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.94099426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44099426 74.12200165 Tm [(ne)-1(uro)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.50900269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.00900269 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.28599548 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.78599548 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.95700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.45700073 74.12200165 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 89.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.47499847 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.41600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.91600037 89.72200012 Tm [(ne)-1(uro)1(gen)-1(esis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.51499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.01499939 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.29200745 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.79200745 89.72200012 Tm [(axo)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.59599304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.09599304 89.72200012 Tm [(guida)1(n)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.69099426 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.19099426 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.46800232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(maintenanc)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.6609993 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.1609993 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.01000214 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.51000214 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.4509964 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.9509964 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.40699768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.90699768 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.42300415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.92300415 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.44099426 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.94099426 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.94200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.44200134 105.3219986 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.7480011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.2480011 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.08999634 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.30799866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.80799866 120.92199707 Tm [(fib)1(rosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.95600128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.45600128 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.29799652 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.79799652 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.7990036 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.2990036 120.92199707 Tm [(extra)1(oc)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.31799316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.81799316 120.92199707 Tm [(musc)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.14399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.64399719 120.92199707 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.61500549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.11500549 120.92199707 Tm [(3.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.55900574 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.60400009 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.10400009 136.52200317 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.01899719 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.51899719 136.52200317 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.68800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.18800354 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1289978 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.6289978 136.52200317 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.00100708 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.50100708 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.42300415 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.92300415 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 152.12199402 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.16600037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.66600037 152.12199402 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.22699738 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.72699738 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.56900024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06900024 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52500153 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.02500153 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.54100037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.04100037 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.602005 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.102005 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.79200745 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.29200745 152.12199402 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.55999756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.05999756 152.12199402 Tm [(chromos)1(o)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 172.05000305 0.75 m 172.05000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>