%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.30699921 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.98300171 23.67700005 Tm 0 Tr [(TUB)1(B3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.55200195 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.99200439 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TUBB3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.84799957 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.3480072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.5980072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TUB)1(B3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.33200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.70600128 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.35600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.72999573 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.28900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.66299438 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.45899963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBB4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.59799957 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0013001400040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.59799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.09799957 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 176.92500305 0.75 l 176.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 177.92500305 -0.25 l 177.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 177.67500305 172.3500061 l h f* Q q 1 0 0 1 177.30000305 0 cm -0.625 -0.25 m 246.125 -0.25 l 246.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.88500214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.38500214 11.72200012 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.32200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.82200623 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.08599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.58599854 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.42799377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.92799377 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.92900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.42900085 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.61099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11099243 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ubulin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.1760006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.6760006 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.98300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.48300171 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.73100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.23100281 27.3220005 Tm [(Be)-1(t)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.31199646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.81199646 27.3220005 Tm [(tub)1(u)-1(lins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.50700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.00700378 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.5249939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.0249939 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.39900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89900208 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.74099731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24099731 27.3220005 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.42199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.77799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.27799988 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.58499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.08499908 42.92200089 Tm [(fa)1(mi)-1(lies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.06999969 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.56999969 42.92200089 Tm [(\(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.20999908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.70999908 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.98699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.48699951 42.92200089 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.66900635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.16900635 42.92200089 Tm [(tub)1(u)-1(lins\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.86999512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.36999512 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.59199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(heterod)1(ime)-1(riz)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.31999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.81999969 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.09700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.59700012 58.52199936 Tm [(assemble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.69299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.19299316 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.26800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.76800537 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.47900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.97900391 58.52199936 Tm [(mic)-1(r)1(otubules.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.06900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.56900024 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.12999725 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.62999725 74.12200165 Tm [(prima)1(rily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.60800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.10800171 74.12200165 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.26199341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.76199341 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.70300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.20300293 74.12200165 Tm [(ne)-1(uro)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.27099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.77099609 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.04800415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 89.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.52500153 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.02500153 89.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.39399719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.89399719 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.83499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.33499908 89.72200012 Tm [(ne)-1(uro)1(gen)-1(esis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.93400574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.43400574 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.71099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.21099854 89.72200012 Tm [(axo)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.01499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.51499939 89.72200012 Tm [(guida)1(n)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.88299942 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.38299942 105.3219986 Tm [(maintenanc)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.04399872 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.54399872 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.39300537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.89300537 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.83399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.33399963 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.78999329 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.28999329 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.30599976 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.82400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.32400513 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.32499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.30599976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.80599976 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.64799881 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.14799881 120.92199707 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.45600128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.95600128 120.92199707 Tm [(fib)1(rosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.10399628 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.60399628 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.44599915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.94599915 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.94700623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.44700623 120.92199707 Tm [(extra)1(oc)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.46600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.96600342 120.92199707 Tm [(musc)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 136.52200317 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.74300003 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.24300003 136.52200317 Tm [(3.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.68700027 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.18700027 136.52200317 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.79100037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.29100037 136.52200317 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.20600128 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.70599365 136.52200317 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.875 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.375 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.31599426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.81599426 136.52200317 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.18800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.68800354 136.52200317 Tm [(tr)1(ans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(cript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.68199921 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.18199921 152.12199402 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.51499939 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.01499939 152.12199402 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.57600403 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.07600403 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.91799927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.41799927 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.87399292 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.37399292 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.88999939 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.38999939 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.95100403 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.45100403 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.14100647 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 167.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.56300354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.06300354 167.72200012 Tm [(6.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.50700378 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 177.30000305 0.75 m 177.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>