%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 129 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.36599731 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 165.13000488 23.67700005 Tm 0 Tr [(tY)1(FP)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 211.49299622 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 321.93301392 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(tYF)-1(P)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.63300323 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.13299561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.38299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(tYFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.61599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.98999786 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.76199341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.13600159 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.83099365 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.6269989 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C5DE)-1(Lq14.3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.23799896 12.82499981 Tm [(DE)-1(L5q14.3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.69400024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tYF)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88300323 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tYF)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88300323 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 159.67500305 94.34999847 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ant)1(e)-1(nna)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.90399933 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.21099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.71099854 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.93299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.43299866 11.72200012 Tm [(mod)1(u)-1(la)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.88600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.38600159 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.38699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.88699341 11.72200012 Tm [(color)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.67500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.17500305 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.51699829 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.51800537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.01800537 11.72200012 Tm [(biolum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ine)-1(scen)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.99900055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49900055 27.3220005 Tm [(emi)-1(s)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.4280014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.9280014 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.76999664 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26999664 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.27100372 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.77100372 27.3220005 Tm [(luc)-1(iferas)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.69700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.19700623 27.3220005 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.38800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.88800049 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.88900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.38900757 27.3220005 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.11799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.61799622 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.46000671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(YFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.71899986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.21899986 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.49599838 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.99599838 42.92200089 Tm [(only)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.42200089 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.92200089 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.25 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.75 42.92200089 Tm [(temperat)1(ure)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.51600647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.01600647 42.92200089 Tm [(below)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.09300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.59300232 42.92200089 Tm [(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.14900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.64900208 42.92200089 Tm [(degrees)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.08500671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.58500671 42.92200089 Tm [(Celsiu)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.54600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(luc)-1(iferas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.75899887 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.25899887 58.52199936 Tm [(exhibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.52600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02600098 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.00099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.50099945 58.52199936 Tm [(bimod)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.92500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.42500305 58.52199936 Tm [(emi)-1(s)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.35400391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.85400391 58.52199936 Tm [(spectrum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.15600586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.65600586 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.05200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.55200195 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.5269928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ne)-1(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75799942 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25799942 74.12200165 Tm [(peak)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.98699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.48699951 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.81499863 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.31499863 74.12200165 Tm [(54)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.14800262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.64800262 74.12200165 Tm [(nM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.98699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.48699951 74.12200165 Tm [(\(ye)-1(llow)1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.65299988 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.59399414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.09399414 74.12200165 Tm [(ad)1(dition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.99299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.49299622 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.56799316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.06799316 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.06900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.56900024 74.12200165 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.94299316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.44299316 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.77099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(48)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 89.72200012 Tm [(nM.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.8390007 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 159.67500305 16.35000038 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.06500053 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56499863 11.72200012 Tm [(FC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.36700058 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 159.67500305 16.35000038 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tY)1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.0720005 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 159.67500305 16.35000038 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.26200104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.76200104 11.72200012 Tm [(tY)1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.83399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.33399963 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.64099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.14099884 11.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.29499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.79499817 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.73599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.23599243 11.72200012 Tm [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.85099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.35099792 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.76100159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 159.67500305 16.35000038 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P21)-1(57)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 159.67500305 16.35000038 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 0.75 m 159.30000305 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 95.09999847 m 159.30000305 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 111.44999695 m 159.30000305 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 127.79999542 m 159.30000305 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 144.1499939 m 159.30000305 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 160.5 m 159.30000305 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 176.4750061 m 423.17498779 176.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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