%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 108 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.88800049 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 164.6519928 23.67700005 Tm 0 Tr [(tRFP)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 211.97099304 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 322.41101074 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(tRFP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 119.21700287 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.71699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.96699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(tRFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.19999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.5739975 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.34599304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.72000122 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.41499329 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.21099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tRFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.46700287 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tRFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.46700287 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 185.17500305 0.75 l 185.17500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 186.17500305 -0.25 l 186.17500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 185.92500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 185.92500305 94.34999847 l h f* Q q 1 0 0 1 185.55000305 0 cm -0.625 -0.25 m 237.875 -0.25 l 237.875 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.73900032 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.23900032 11.72200012 Tm [(Flu)-1(o)1(re)-1(s)1(c)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.91000366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.41000366 11.72200012 Tm [(Pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.97499847 11.72200012 Tm [(\(RFP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.1499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.6499939 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.21099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.71099854 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.68600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.18600464 11.72200012 Tm [(versat)1(il)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.34300232 11.72200012 Tm [(biolo)1(gi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.88300037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.38299942 27.3220005 Tm [(marker)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.66999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.16999817 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.44800186 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.94799805 27.3220005 Tm [(monito)1(rin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.25299835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.75299835 27.3220005 Tm [(ph)1(y)-1(sio)1(l)-1(o)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.24000549 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.74000549 27.3220005 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.03700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(visualizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.71900177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.21900177 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.52600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.02600098 42.92200089 Tm [(localizat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.00300598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.50300598 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.77999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.27999878 42.92200089 Tm [(detecting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.16700745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.66700745 42.92200089 Tm [(tr)1(ans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(genic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.31699944 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.81699944 58.52199936 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.77100372 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.27100372 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.21199799 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.71199799 58.52199936 Tm [(vivo.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.44300079 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.94300079 58.52199936 Tm [(RFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.10600281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.60600281 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.63999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.13999939 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.9940033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.4940033 58.52199936 Tm [(exc)-1(it)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.28599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.78599548 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.29800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.79800415 58.52199936 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(48)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.43899918 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.93899918 74.12200165 Tm [(nm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.91799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.41799927 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.57600021 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.07600021 74.12200165 Tm [(53)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.90899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.40899658 74.12200165 Tm [(nm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.38800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.88800049 74.12200165 Tm [(laser)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.96700287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.46700287 74.12200165 Tm [(line)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.90899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.40899658 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68600464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.18600464 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.74699402 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.24699402 74.12200165 Tm [(op)1(timally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.42599487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.92599487 74.12200165 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(etec)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.29499817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.79499817 89.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.1230011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.6230011 89.72200012 Tm [(58)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.45600128 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.95600128 89.72200012 Tm [(nm.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.10199738 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 185.17500305 0.75 l 185.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.17500305 -0.25 l 186.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 185.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 185.92500305 16.35000038 l h f* Q q 1 0 0 1 185.55000305 0 cm -0.625 -0.25 m 237.875 -0.25 l 237.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 185.17500305 0.75 l 185.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.17500305 -0.25 l 186.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 185.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 185.92500305 16.35000038 l h f* Q q 1 0 0 1 185.55000305 0 cm -0.625 -0.25 m 237.875 -0.25 l 237.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tR)1(F)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.51600075 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 185.17500305 0.75 l 185.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.17500305 -0.25 l 186.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 185.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 185.92500305 16.35000038 l h f* Q q 1 0 0 1 185.55000305 0 cm -0.625 -0.25 m 237.875 -0.25 l 237.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Rec)-1(o)1(mbinant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.2120018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.7120018 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.51899719 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.36100006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.86100006 11.72200012 Tm [(tR)1(F)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3769989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 185.17500305 0.75 l 185.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.17500305 -0.25 l 186.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 185.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 185.92500305 16.35000038 l h f* Q q 1 0 0 1 185.55000305 0 cm -0.625 -0.25 m 237.875 -0.25 l 237.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(26)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 185.17500305 0.75 l 185.17500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 186.17500305 -0.25 l 186.17500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 27.3220005 Tm [(Positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.59600067 27.3220005 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 185.92500305 0.75 m 422.42498779 0.75 l 422.42498779 47.54999924 l 185.92500305 47.54999924 l h f* Q q 1 0 0 1 185.55000305 0 cm -0.625 -0.25 m 237.875 -0.25 l 237.875 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61500168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11500168 11.72200012 Tm [(over-)1(e)-1(xp)1(re)-1(s)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.9509964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.4509964 11.72200012 Tm [(lysates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.37600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.87600708 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.6230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.1230011 11.72200012 Tm [(rec)-1(o)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(binant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.56200027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.06200027 27.3220005 Tm [(tR)1(F)-1(P)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.74499893 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.24499893 27.3220005 Tm [(TurboFP60)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.97699738 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.47699738 27.3220005 Tm [(TurboFP63)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.20899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.70899963 27.3220005 Tm [(fluoresce)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.98599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.47299957 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.55000305 0.75 m 185.55000305 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.55000305 95.09999847 m 185.55000305 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.55000305 111.44999695 m 185.55000305 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.55000305 127.79999542 m 185.55000305 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.55000305 144.1499939 m 185.55000305 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.55000305 160.5 m 185.55000305 207.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67500305 m 423.17498779 207.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>