%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.0719986 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 163.83599854 23.67700005 Tm 0 Tr [(tGFP)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 212.78799438 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.22799683 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(tGFP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.13999939 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 172.63999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.88999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(tG)1(F)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.1230011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.49700165 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.26899719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.64300537 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.96400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.33799744 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.13400269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tGFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.38999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tGFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.38999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 175.42500305 125.55000305 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gr)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.88800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.38800049 11.72200012 Tm [(fluoresce)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.66500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.16500092 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.47200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.97200012 11.72200012 Tm [(\(GFP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.46400452 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.0249939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.5249939 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.5 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173 11.72200012 Tm [(27)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.78599548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.28599548 11.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.32799911 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.82799911 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.53900146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.03900146 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.04000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.54000092 27.3220005 Tm [(jel)-1(lyfish)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.82700348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.32700348 27.3220005 Tm [(Aequor)1(e)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.30799866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.80799866 27.3220005 Tm [(victoria)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.48800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.98800659 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.08500671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(emi)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.45400047 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.95400047 42.92200089 Tm [(gr)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.90599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.40599823 42.92200089 Tm [(light)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.84700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.34700012 42.92200089 Tm [(\(emission)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.28199768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.78199768 42.92200089 Tm [(peak)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.51100159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.01100159 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.33900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.83900452 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.81399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.31399536 42.92200089 Tm [(wa)1(ve)-1(lenth)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.16700745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.66700745 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.50900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(50)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 58.52199936 Tm [(nm\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.31800079 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.81800079 58.52199936 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.11799622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.61799622 58.52199936 Tm [(exc)-1(it)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.41000366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.91000366 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.42199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.92199707 58.52199936 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.71699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.21699524 58.52199936 Tm [(light)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.65800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.15800476 58.52199936 Tm [(\(exc)-1(it)1(atio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.08299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.58299255 58.52199936 Tm [(peak)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.31199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.32800007 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.8029995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.3029995 74.12200165 Tm [(wa)1(ve)-1(lenth)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.15599823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.65599823 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.4980011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.9980011 74.12200165 Tm [(39)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.83100128 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.33100128 74.12200165 Tm [(nm\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.48200226 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.98200226 74.12200165 Tm [(Gr)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.86999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.36999512 74.12200165 Tm [(Flu)-1(o)1(re)-1(s)1(c)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.04100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.54100037 74.12200165 Tm [(Pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(\(GFP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.0379982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.5379982 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.22000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.72000122 89.72200012 Tm [(bec)-1(o)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.34899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.84899902 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.37000275 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.87000275 89.72200012 Tm [(invaluable)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.67500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.17500305 89.72200012 Tm [(to)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.36599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.86599731 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.80700684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.30700684 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.71699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.21699524 89.72200012 Tm [(biolo)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 105.3219986 Tm [(researc)-1(h)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.7120018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.2120018 105.3219986 Tm [(sinc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.93900299 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.43900299 105.3219986 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.35299683 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.85299683 105.3219986 Tm [(intrinsic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.59899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.09899902 105.3219986 Tm [(fluoresce)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.37600708 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.87600708 105.3219986 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.91000366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.41000366 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.26400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.76400757 105.3219986 Tm [(vis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ualized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.59900093 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.09899902 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.04000092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.54000092 120.92199707 Tm [(living)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.7519989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.2519989 120.92199707 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.9940033 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.42500305 16.35000038 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.06500053 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56499863 11.72200012 Tm [(IP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.71699905 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.42500305 16.35000038 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tG)1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.42500305 16.35000038 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.26200104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.76200104 11.72200012 Tm [(tG)1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.09500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.59500122 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.90200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.40200043 11.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.05599976 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.99699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.49699402 11.72200012 Tm [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.11199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.61199951 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.02200317 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.42500305 16.35000038 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P42)-1(21)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.42500305 16.35000038 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(26)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30003357 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 0.75 m 175.05000305 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 126.30000305 m 175.05000305 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 142.65000916 m 175.05000305 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 159.00001526 m 175.05000305 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 175.35002136 m 175.05000305 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 191.70002747 m 175.05000305 207.30003357 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30003357 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 191.32502747 m 422.42498779 191.32502747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67503357 m 423.17498779 207.67503357 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>