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1 0 0 -1 240.7230072 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 351.16299438 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(Strep)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 119.86799622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 122.24199677 12.82499981 Tm [(tag)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 135.73100281 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 138.10499573 12.82499981 Tm [(II)] TJ ET EMC /P <</Lang (zh-CN) /MCID 16 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 146.02099609 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 17 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 198.52099609 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 209.02099609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(Stre)1(p)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 106.47699738 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 108.85099792 12.82499981 Tm [(tag)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 122.33999634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 124.71399689 12.82499981 Tm [(II)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 130.00500488 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 132.3789978 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 161.15100098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 163.5249939 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 213.84599304 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 216.22000122 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 254.01600647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Strep)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 85.74299622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 88.11699677 12.82499981 Tm [(tag)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 101.60600281 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 103.98000336 12.82499981 Tm [(II)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 109.27100372 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Strep)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 85.74299622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 88.11699677 12.82499981 Tm [(tag)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 101.60600281 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 103.98000336 12.82499981 Tm [(II)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 109.27100372 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0020>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130022000E>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <</MCID 88 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 89 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <</MCID 91 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 173.92500305 172.3500061 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Strept)1(avidin)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 51.98300171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 56.48300171 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 63.04399872 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 67.54399872 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 72.51899719 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 77.01899719 11.72200012 Tm [(tet)1(rameric)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 121.1269989 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 125.6269989 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 156.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 161.43400574 11.72200012 Tm [(purified)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 194.93800354 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 199.43800354 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 220.14900208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 224.64900208 11.72200012 Tm [(Stre)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pt)1(omyc)-1(es)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 41.80500031 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 46.30500031 27.3220005 Tm [(avid)1(i)-1(nii.)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 79.0530014 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 83.5530014 27.3220005 Tm [(It)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 89.55200195 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 94.05200195 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 108.73400116 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 113.23400116 27.3220005 Tm [(wid)1(e)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 133.5980072 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 138.0980072 27.3220005 Tm [(use)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 152.91600037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 157.41600037 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 165.35699463 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 169.85699463 27.3220005 Tm [(nume)-1(ro)1(u)-1(s)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 213.35800171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 217.85800171 27.3220005 Tm [(mole)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(cu)-1(lar)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 20.86499977 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 25.36499977 42.92200089 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 67.3809967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 71.8809967 42.92200089 Tm [(pro)1(tocols)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 112.65799713 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 117.15799713 42.92200089 Tm [(dues)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 137.73300171 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 142.23300171 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 151.30799866 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 155.80799866 42.92200089 Tm [(its)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 165.72200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 170.22200012 42.92200089 Tm [(st)1(rong)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 198.20199585 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 202.70199585 42.92200089 Tm [(af)1(fini)-1(t)1(y)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 232.3690033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 236.8690033 42.92200089 Tm [(f)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 9.15799999 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 13.65799999 58.52199936 Tm [(biot)1(in.)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 40.98300171 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 45.48300171 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 61.29000092 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 65.79000092 58.52199936 Tm [(orig)1(in)-1(a)1(l)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 98.41100311 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 102.91100311 58.52199936 Tm [(Strep-)1(tag)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 143.727005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 148.227005 58.52199936 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 164.47399902 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 168.97399902 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 173.94900513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 178.44900513 58.52199936 Tm [(nin)-1(e)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 197.04200745 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 201.54200745 58.52199936 Tm [(amino)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 228.61199951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 233.11199951 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ci)-1(d)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 12.66499996 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 17.16500092 74.12200165 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 50.37900162 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 54.87900162 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 73.27500153 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 77.77500153 74.12200165 Tm [(hig)1(h)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 97.01000214 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 101.51000214 74.12200165 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 143.97900391 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 148.47900391 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 164.7559967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 169.2559967 74.12200165 Tm [(af)1(fini)-1(t)1(y)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 198.92300415 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 203.42300415 74.12200165 Tm [(to)1(war)1(ds)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 237.93800354 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(st)1(re)-1(p)1(tavid)1(in)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 50.95500183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 55.45500183 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 80.55200195 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 85.05200195 89.72200012 Tm [(allow)1(s)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 111.80999756 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 116.30999756 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 130.31100464 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 134.81100464 89.72200012 Tm [(simple)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 163.05499268 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 167.55499268 89.72200012 Tm [(purificat)1(ion)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 216.69900513 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 221.19900513 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 230.04100037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 234.54100037 89.72200012 Tm [(p)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(rot)1(e)-1(in)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 25.55900002 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 30.05900002 105.3219986 Tm [(by)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 40.57099915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 45.07099915 105.3219986 Tm [(use)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 59.88899994 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 64.38899994 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 73.23100281 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 77.73100281 105.3219986 Tm [(af)1(fini)-1(t)1(y)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 107.39800262 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 111.89800262 105.3219986 Tm [(colu)-1(mns,)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 150.38499451 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 154.88499451 105.3219986 Tm [(but)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 169.53199768 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 174.03199768 105.3219986 Tm [(required)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 210.57299805 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 215.07299805 105.3219986 Tm [(ad)1(diti)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(on)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 11.26799965 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 15.76799965 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 24.84300041 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 29.34300041 120.92199707 Tm [(only)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 47.76900101 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 52.26900101 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 66.26999664 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 70.76999664 120.92199707 Tm [(C-t)1(e)-1(r)1(min)-1(us)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 118.66600037 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 123.16600037 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 132.00799561 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 136.50799561 120.92199707 Tm [(rec)-1(o)1(mbinant)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 191.28100586 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 195.78100586 120.92199707 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 233.41999817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(To)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 10.88099957 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 15.38099957 136.52200317 Tm [(also)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 32.63800049 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 37.13800049 136.52200317 Tm [(allow)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 59.72999954 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 64.23000336 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 69.20500183 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 73.70500183 136.52200317 Tm [(Strep-)1(tag)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 114.52100372 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 119.02100372 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 128.09599304 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 132.59599304 136.52200317 Tm [(be)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 143.44999695 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 147.94999695 136.52200317 Tm [(placed)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 176.44400024 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 180.94400024 136.52200317 Tm [(at)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 189.27200317 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 193.77200317 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 207.772995 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 212.272995 136.52200317 Tm [(N-t)1(e)-1(r)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(minu)-1(s)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 26.08600044 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 30.58600044 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 39.4280014 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 43.9280014 152.12199402 Tm [(rec)-1(o)1(mbinant)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 98.7009964 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 103.2009964 152.12199402 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 140.83999634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 145.33999634 152.12199402 Tm [(it)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 151.08799744 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 155.58799744 152.12199402 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 171.83500671 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 176.33500671 152.12199402 Tm [(re-engine)-1(ered)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 237.63400269 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 16.27700043 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 20.77700043 167.72200012 Tm [(re-named)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 63.02999878 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 67.52999878 167.72200012 Tm [(Strep-)1(tag)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 108.34600067 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 112.84600067 167.72200012 Tm [(II.)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 120.30400085 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 269 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 270 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 271 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 188.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 273 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 278 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 279 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Strep)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 22.83799934 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 27.33799934 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 41.42200089 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 45.92200089 11.72200012 Tm [(II)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 51.21300125 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 205.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 0.75 m 173.55000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 173.1000061 m 173.55000305 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 189.45001221 m 173.55000305 205.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 205.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.07501221 m 422.42498779 189.07501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 205.42501831 m 423.17498779 205.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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