%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 120 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.01999664 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 161.78399658 23.67700005 Tm 0 Tr [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.18200684 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.15600586 23.67700005 Tm [(Tag)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.83999634 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 325.27999878 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.9489975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.32299805 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.03700256 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.53700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.03700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.93199921 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.02100372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.39499664 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.16700745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.54100037 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.86199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.23599243 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.03199768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.8239975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.19799805 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.28700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.8239975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.19799805 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.28700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.91100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.28500366 12.82499981 Tm [(protein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.147995 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.98300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.35699463 12.82499981 Tm [(the)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.61500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.98899841 12.82499981 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.81300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.18699646 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.27600098 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 174.67500305 0.75 l 174.67500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 175.67500305 -0.25 l 175.67500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.42500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 175.42500305 172.3500061 l h f* Q q 1 0 0 1 175.05000305 0 cm -0.625 -0.25 m 248.375 -0.25 l 248.375 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(S-t)1(ag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.17200089 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.67200089 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.23300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.73300171 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73400116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.23400116 11.72200012 Tm [(name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.29399872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.79399872 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.13600159 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.65699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.15699768 11.72200012 Tm [(oligo)1(peptid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.36099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.86099243 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.14300537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.64300537 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.35400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pa)1(n)-1(creatic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.56100082 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06100082 27.3220005 Tm [(ribo)1(n)-1(ucle)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.71600342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.21600342 27.3220005 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.5490036 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.0490036 27.3220005 Tm [(\(RNas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.4940033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.9940033 27.3220005 Tm [(A\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.49899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.99899292 27.3220005 Tm [(If)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.76499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.26499939 27.3220005 Tm [(RNas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.70399475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.20399475 27.3220005 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.53700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.03700256 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.5980072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.0980072 27.3220005 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(igested)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.64100075 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.14099884 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.53699875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.03699875 42.92200089 Tm [(subt)1(il)-1(isin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.30799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.80799866 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.78299713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.28299713 42.92200089 Tm [(single)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.647995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.147995 42.92200089 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.36199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.86199951 42.92200089 Tm [(bo)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.63400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.13400269 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.69500732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.19500732 42.92200089 Tm [(cl)-1(ea)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ved,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75399971 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25399971 58.52199936 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.90100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.40100098 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.40200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.90200043 58.52199936 Tm [(resulting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.60299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.10299683 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.28399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.78399658 58.52199936 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.0249939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.5249939 58.52199936 Tm [(remain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.41700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.91700745 58.52199936 Tm [(weakly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.16299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.66299438 58.52199936 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ound)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.56999969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06999969 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.14500046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.64500046 74.12200165 Tm [(eac)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.78099823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.28099823 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.44000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.94000244 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.21700287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.71700287 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.71800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.21800232 74.12200165 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.69099426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.19099426 74.12200165 Tm [(calle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.33200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.83200073 74.12200165 Tm [(ribo)1(n)-1(ucle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.24699974 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74699974 89.72200012 Tm [(S,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.1079998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.6079998 89.72200012 Tm [(remains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.66600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.16600037 89.72200012 Tm [(active)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.23200226 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.73200226 89.72200012 Tm [(alt)1(hough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.56199646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.06199646 89.72200012 Tm [(eac)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.19799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.69799805 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.53999329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.03999329 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.04100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.54100037 89.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.22200012 89.72200012 Tm [(pro)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(uc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.57799911 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.07799911 105.3219986 Tm [(alone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.8219986 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.3219986 105.3219986 Tm [(sho)1(ws)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.02300262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.52300262 105.3219986 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.79100037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.29100037 105.3219986 Tm [(en)-1(z)1(y)-1(ma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.80099487 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.30099487 105.3219986 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.93899536 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.43899536 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.2460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.7460022 105.3219986 Tm [(N-t)1(e)-1(r)1(mi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(nus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.25800037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.75799942 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.60000038 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.09999847 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.10100174 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.60100174 120.92199707 Tm [(orig)1(in)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.22200012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.72200012 120.92199707 Tm [(RNas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.16100311 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.66100311 120.92199707 Tm [(A,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.16000366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.66000366 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.91700745 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.41700745 120.92199707 Tm [(calle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.55799866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05799866 120.92199707 Tm [(S-p)1(e)-1(p)1(tide,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.52600098 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.02600098 120.92199707 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(onsist)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.51399994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.01399994 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.85599899 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.35599899 136.52200317 Tm [(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.91199875 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.41199875 136.52200317 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.48200226 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.98200226 136.52200317 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.78800201 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.28800201 136.52200317 Tm [(KETA)1(AAK)1(F)-1(E)1(RQH)-1(MD)1(S)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.72900391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.22900391 136.52200317 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.42300415 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.92300415 136.52200317 Tm [(Ta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 152.12199402 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.51599884 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 152.12199402 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.05000305 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.55000305 152.12199402 Tm [(rec)-1(o)1(gnize)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.55699921 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.05699921 152.12199402 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.7769928 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.2769928 152.12199402 Tm [(internal,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.19599915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.69599915 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.9730072 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.4730072 152.12199402 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.53300095 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.03300095 167.72200012 Tm [(S-t)1(agg)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.82499695 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.32499695 167.72200012 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.96399689 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.05000305 0.75 m 175.05000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>