%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 104 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 4.5 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 58.46500015 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 130.22900391 23.67700005 Tm 0 Tr [(mRaspb)1(e)-1(rr)-1(y)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 246.39500427 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 356.83499146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(mRaspb)-1(e)1(rry)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 151.30700684 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 203.80700684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.05700684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(m)1(Ras)-1(pber)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.28999329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.66400146 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.43600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.80999756 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.1309967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.50500488 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.30099487 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mRaspb)-1(e)1(rry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.55699921 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mRaspb)-1(e)1(rry)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.17700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.5510025 12.82499981 Tm [(Am)1(C)-1(y)1(an)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.23300171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NULL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.27300072 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(mRas)1(pberry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.68799973 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.26200104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.76200104 11.72200012 Tm [(mRas)1(pberry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.44999695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.94999695 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.25700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.75700378 11.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.91099548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.41099548 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.352005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.852005 11.72200012 Tm [(HEK29)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.30799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.80799866 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.21800232 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(26)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 27.3220005 Tm [(Positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.59600067 27.3220005 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 47.54999924 l 149.92500305 47.54999924 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61500168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11500168 11.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.69100189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.19100189 11.72200012 Tm [(were)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.94599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.44599915 11.72200012 Tm [(tr)1(ansfec)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.87800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.37800598 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.77400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27400208 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.7749939 11.72200012 Tm [(pCMV6-ENTRY)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.32600403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.82600403 11.72200012 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ntro)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.45199966 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.95199966 27.3220005 Tm [(\(Le)-1(f)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.15599823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.65599823 27.3220005 Tm [(lane\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.68399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18399811 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.34200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.84200287 27.3220005 Tm [(pCMV6-ENTRY)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.39300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.89300537 27.3220005 Tm [(mRas)1(pberry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.58099365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.08099365 27.3220005 Tm [(ne)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.73899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.23899841 27.3220005 Tm [(cDNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.25698853 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.75698853 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 42.92200089 Tm [(48)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.2140007 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.7140007 42.92200089 Tm [(hrs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.85800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.35800171 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.63499832 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.13500214 42.92200089 Tm [(lyse)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.32299805 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 129.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 149.17500305 0.75 l 149.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.17500305 -0.25 l 150.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Recommend)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.37000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.87000275 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 130.71600342 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.92500305 16.35000038 l h f* Q q 1 0 0 1 149.55000305 0 cm -0.625 -0.25 m 273.875 -0.25 l 273.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(10)-1(00)-1(-)1(5)-1(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.11600113 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 145.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 0.75 m 149.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 17.10000038 m 149.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 33.45000076 m 149.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 49.80000305 m 149.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 66.15000153 m 149.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 82.5 m 149.55000305 129.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.55000305 130.05000305 m 149.55000305 145.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 145.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 129.67500305 m 422.42498779 129.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 146.02500916 m 423.17498779 146.02500916 l S Q Q q 1 0 0 1 0 554.19000244 cm Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>