%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 117 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 71.41400146 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.17799377 23.67700005 Tm 0 Tr [(mO)-1(ran)1(g)-1(e)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 233.44500732 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 343.88500977 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(mOrange)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 139.46299744 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 191.96299744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.21299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(m)1(O)-1(r)1(an)-1(g)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.4469986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.82099915 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.59300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.96699524 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.28799438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.66200256 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.45799255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mOrange)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.71299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mOrange)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.71299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 176.92500305 109.94999695 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(mOrang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.58800125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.08800125 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.64899826 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.14899826 11.72200012 Tm [(extremel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.41100311 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.91100311 11.72200012 Tm [(brig)1(ht)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.14199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.64199829 11.72200012 Tm [(ora)1(n)-1(g)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.18400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.68400574 11.72200012 Tm [(fluoresce)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.19400024 11.72200012 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.39999962 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 27.3220005 Tm [(monomers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.46399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.96399689 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.06099701 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.56099701 27.3220005 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.59500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.09500122 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.94900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.44900513 27.3220005 Tm [(used)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.02400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.52400208 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.66499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.16499329 27.3220005 Tm [(ta)1(gs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.41499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.91499329 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.07299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.57299805 27.3220005 Tm [(repor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ers.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.375 42.92200089 Tm [(mOrang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.96300125 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.46299744 42.92200089 Tm [(fluoresce)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.47299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.97299957 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.44599915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.94599915 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.50700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.00700378 42.92200089 Tm [(mutant)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.3789978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.8789978 42.92200089 Tm [(derive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.96800041 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.4679985 58.52199936 Tm [(mRFP1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.00900269 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.98400116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.48400116 58.52199936 Tm [(monomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.79100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.29100037 58.52199936 Tm [(mutant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.49699402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.99699402 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.83900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.33900452 58.52199936 Tm [(DsR)1(e)-1(d)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.26600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.76600647 58.52199936 Tm [(wh)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 74.12200165 Tm [(wa)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.28899956 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.78899956 74.12200165 Tm [(developed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.21099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.71099854 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.15200043 74.12200165 Tm [(Dr.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.61000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.11000061 74.12200165 Tm [(Rog)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.00700378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.50700378 74.12200165 Tm [(Tsie)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.88000488 74.12200165 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.88000488 74.12200165 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.04600525 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.54600525 74.12200165 Tm [(lab)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.66400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.16400146 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.67599487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.17599487 74.12200165 Tm [(direct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(mutag)1(e)-1(nesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.07900238 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.57900238 89.72200012 Tm [(mOrang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.16699982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.66699982 89.72200012 Tm [(exc)-1(it)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.58599854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.08599854 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.36300659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.86300659 89.72200012 Tm [(emi)-1(s)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.79200745 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(maxima)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.77199936 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.27199936 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.79000092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.29000092 105.3219986 Tm [(54)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.1230011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.6230011 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.90000153 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.40000153 105.3219986 Tm [(56)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.23300171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.73300171 105.3219986 Tm [(nm,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.8789978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.3789978 105.3219986 Tm [(respec)-1(t)1(ive)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.35899353 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.92500305 16.35000038 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.92500305 16.35000038 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(mOrang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.58800125 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.92500305 16.35000038 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(mOrang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.58800125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.08800125 11.72200012 Tm [(ta)1(gged)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.79299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.29299927 11.72200012 Tm [(rec)-1(o)1(mbinant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.06599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.56599426 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.8730011 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.92500305 16.35000038 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Frozen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.0170002 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.51699829 11.72200012 Tm [(sec)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.31800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.81800079 11.72200012 Tm [(Brain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.81700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.31700134 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.0490036 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(Recommend)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.78299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.28299713 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 120.1289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.92500305 16.35000038 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(25)-1(-)1(1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 191.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 176.17500305 0.75 l 176.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.17500305 -0.25 l 177.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.59600067 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.92500305 16.35000038 l h f* Q q 1 0 0 1 176.55000305 0 cm -0.625 -0.25 m 246.875 -0.25 l 246.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61500168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11500168 11.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.69100189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.19100189 11.72200012 Tm [(were)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.94599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.44599915 11.72200012 Tm [(tr)1(ansfec)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.87800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.37800598 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.77400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27400208 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.7749939 11.72200012 Tm [(pCMV6-EN)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 0.75 m 176.55000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 110.69999695 m 176.55000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 127.04999542 m 176.55000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 143.3999939 m 176.55000305 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 159.75 m 176.55000305 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 176.1000061 m 176.55000305 191.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.55000305 192.45001221 m 176.55000305 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 175.7250061 m 422.42498779 175.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 192.07501221 m 422.42498779 192.07501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 208.42501831 m 423.17498779 208.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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