%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 112 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.14299774 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 167.90699768 23.67700005 Tm 0 Tr [(GST)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 208.71699524 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.15701294 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(GST)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.31500244 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.81500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.06500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(G)1(S)-1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.67299652 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.44500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.81900024 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.13999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.51400757 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.30999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.56500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.56500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.93900299 12.82499981 Tm [(tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.4280014 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 166.42500305 109.94999695 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.04599953 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.54599953 11.72200012 Tm [(\(Gluta)1(thio)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.17700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.67700195 11.72200012 Tm [(S-T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.9240036 11.72200012 Tm [(ransf)1(e)-1(ra)1(se)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.96299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.46299744 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.02400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.52400208 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.99899292 11.72200012 Tm [(26)-1(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.28500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.78500366 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.09199524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.59199524 11.72200012 Tm [(wh)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55500031 27.3220005 Tm [(wa)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.80200005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.30199814 27.3220005 Tm [(wid)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.82500076 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.32499695 27.3220005 Tm [(used)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.90000153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.40000153 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.34100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.84100342 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.84200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.34200287 27.3220005 Tm [(pG)1(EX)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.53599548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.03599548 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.11799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.61799622 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.46000671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.96000671 27.3220005 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.0059967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.5059967 27.3220005 Tm [(plas)1(mi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.21099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.71099854 42.92200089 Tm [(vec)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.73200226 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.23200226 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.3730011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.8730011 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.84799957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.34799957 42.92200089 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.84300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.34300232 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.6499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.1499939 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.54600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.04600525 42.92200089 Tm [(fo)1(re)-1(ig)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.1289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(tein)-1(s)1(.GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.68600082 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.18600082 58.52199936 Tm [(isoenzyme)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.01599884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.51599884 58.52199936 Tm [(ap)1(pear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.5039978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.0039978 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.07899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.57899475 58.52199936 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.46000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.96000671 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.93499756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.43499756 58.52199936 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.75999451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.25999451 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.91999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.44199944 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.94199944 74.12200165 Tm [(pa)1(rasite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.09600067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.59600067 74.12200165 Tm [(deto)1(xific)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.50900269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.00900269 74.12200165 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.16400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.66400146 74.12200165 Tm [(Ot)1(he)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.43600464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.93600464 74.12200165 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.84300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.34300232 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.29999924 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.79999924 89.72200012 Tm [(suspec)-1(t)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.26200104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.76200104 89.72200012 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.61199951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.11199951 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.08700562 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.58700562 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.24699402 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.74699402 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.68800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.18800354 89.72200012 Tm [(inc)-1(reasing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.022995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.522995 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.52400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.02400208 89.72200012 Tm [(so)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(lubility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.99099922 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.49100113 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.33300018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.83300018 105.3219986 Tm [(ha)1(e)-1(mat)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.15699768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.65699768 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.59799957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.09799957 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.09899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.59899902 105.3219986 Tm [(pa)1(rasite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75300598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.25300598 105.3219986 Tm [(gut)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.07499695 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.42500305 16.35000038 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.42500305 16.35000038 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.04599953 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.42500305 16.35000038 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Rec)-1(o)1(mbinant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.2120018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.7120018 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75800323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.25800323 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.56500244 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.42500305 16.35000038 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gluta)1(thio)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.625 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.125 11.72200012 Tm [(S-Transf)1(e)-1(ra)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.40499878 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 19.52199936 Tm [(Positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.59600067 19.52199936 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 166.42500305 31.95000076 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(six)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.12300014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.62300014 11.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.56299973 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.06299973 11.72200012 Tm [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.6780014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.1780014 11.72200012 Tm [(over-)1(e)-1(xp)1(re)-1(s)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.01400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.51400757 11.72200012 Tm [(lysates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.43899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93899536 11.72200012 Tm [(containin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 27.3220005 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.1969986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.6969986 27.3220005 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.74299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.24299622 27.3220005 Tm [(ta)1(gged)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.94799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.44799805 27.3220005 Tm [(rec)-1(o)1(mbinant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.22099304 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.72099304 27.3220005 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.36000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.86000061 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.13699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.63699341 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.01100159 27.3220005 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 0.75 m 166.05000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 110.69999695 m 166.05000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 127.04999542 m 166.05000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 143.3999939 m 166.05000305 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 159.75 m 166.05000305 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 176.1000061 m 166.05000305 207.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 175.7250061 m 422.42498779 175.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67500305 m 423.17498779 207.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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