%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 73.23500061 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.99899292 23.67700005 Tm 0 Tr [(EY)1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.96699524 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.94099426 23.67700005 Tm [(Tag)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 231.625 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 342.06500244 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(EY)-1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.61699677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.99099731 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 137.70500183 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 190.20500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.70500183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EYF)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.22599792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.59999847 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.68900299 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.06300354 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.83500671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.20899963 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.52999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.90400696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.69999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(En)-1(hanced)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.88700104 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.30200195 12.82499981 Tm [(Yell)-1(ow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.50500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.91999817 12.82499981 Tm [(fl)-1(ore)1(scent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.76100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.17599487 12.82499981 Tm [(protein)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.36799622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.78300476 12.82499981 Tm [(eYFP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.18200684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.59698486 12.82499981 Tm [(YF)-1(P)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.18701172 12.82499981 Tm [(Yell)-1(ow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.39001465 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.80499268 12.82499981 Tm [(Fl)-1(uo)-1(r)1(esce)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.7829895 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.19799805 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(enhan)-1(ce)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.98500061 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.35900116 30.49699783 Tm [(Yell)-1(ow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.56199646 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.93599701 30.49699783 Tm [(Fl)-1(uo)-1(r)1(esce)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.91400146 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.28800201 30.49699783 Tm [(Pr)1(o)-1(te)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.57800293 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EY)-1(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.49199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.86599731 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.95500183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 366.58999634 m 416.75 366.58999634 l 416.75 397.79000854 l -1.45000005 397.79000854 l h f* Q q 1 0 0 1 0 366.58999634 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 397.79000854 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 425.72900391 cm q /GS2 gs 1 g 0.375 0.75 m 165.67500305 0.75 l 165.67500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 166.67500305 -0.25 l 166.67500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.42500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 166.42500305 187.94999695 l h f* Q q 1 0 0 1 166.05000305 0 cm -0.625 -0.25 m 257.375 -0.25 l 257.375 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Yellow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(Flu)-1(o)1(re)-1(s)1(c)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.32700348 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.82700348 11.72200012 Tm [(Pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.89199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.39199829 11.72200012 Tm [(\(Y)1(F)-1(P\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.6230011 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.18400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.68400574 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.65899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.15899658 11.72200012 Tm [(gene)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.93600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.43600464 11.72200012 Tm [(mutant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.64199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.14199829 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(gr)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.5719986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.0719986 27.3220005 Tm [(fluoresce)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.08200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.58200073 27.3220005 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.55500031 27.3220005 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.83700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.33700562 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.04800415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.54800415 27.3220005 Tm [(Aequor)1(e)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.52900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.02900696 27.3220005 Tm [(vic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(to)1(ria.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.04700089 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.54700089 42.92200089 Tm [(Its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.7120018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.2120018 42.92200089 Tm [(exc)-1(it)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.1309967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.6309967 42.92200089 Tm [(peak)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.36000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.86000061 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.42099762 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.92099762 42.92200089 Tm [(51)-1(4nm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.73300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.23300171 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.50999451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.00999451 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.92399597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.42399597 42.92200089 Tm [(emi)-1(s)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.35299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.85299683 42.92200089 Tm [(pe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ak)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.375 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.93600082 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.43600082 58.52199936 Tm [(52)-1(7nm)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.41500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.91500092 58.52199936 Tm [(Lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.93499756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.43499756 58.52199936 Tm [(gr)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.38700104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.88700104 58.52199936 Tm [(fluoresce)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.89700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.39700317 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.70399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.20399475 58.52199936 Tm [(\(GFP\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.36300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.86300659 58.52199936 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.61099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.11099243 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.67199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 74.12200165 Tm [(useful)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.35400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.85400009 74.12200165 Tm [(to)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.04499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.54499817 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.48600006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.98600006 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.39600372 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.89600372 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.17299652 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.67299652 74.12200165 Tm [(molec)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.19400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.69400024 74.12200165 Tm [(biolo)1(gy,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.36199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.86199951 74.12200165 Tm [(usually)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.647995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.147995 74.12200165 Tm [(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(plor)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.16500092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.66500092 89.72200012 Tm [(using)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.07500076 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.57500076 89.72200012 Tm [(fluoresce)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.85199738 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.35199738 89.72200012 Tm [(mic)-1(r)1(osc)-1(o)1(py.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.93099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.43099976 89.72200012 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.78100586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.28100586 89.72200012 Tm [(impro)1(ve)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.60299683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(versions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.26200104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76200104 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.60400009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.10400009 105.3219986 Tm [(YFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.82299805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.32299805 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.84100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.34100342 105.3219986 Tm [(Citr)1(i)-1(ne,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.76000214 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.26000214 105.3219986 Tm [(Ve)-1(nus,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.8769989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.3769989 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.65400696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.15400696 105.3219986 Tm [(Yp)1(e)-1(t)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.96000671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.46000671 105.3219986 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03100586 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53100586 105.3219986 Tm [(ha)1(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(reduc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.82799911 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.32799911 120.92199707 Tm [(chloride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.19400024 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.69400024 120.92199707 Tm [(sensitivity,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.22399902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.72399902 120.92199707 Tm [(fa)1(ster)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.8809967 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.3809967 120.92199707 Tm [(mat)1(u)-1(r)1(atio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.28100586 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.78100586 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.05799866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.55799866 120.92199707 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nc)-1(reased)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.60599899 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.10599899 136.52200317 Tm [(brig)1(htness)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.32099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.82099915 136.52200317 Tm [(\(pr)1(oduc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.9019928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.4019928 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.2440033 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.7440033 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.74499512 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.24499512 136.52200317 Tm [(extinc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.73599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.23599243 136.52200317 Tm [(coe)-1(f)1(fic)-1(ie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6760006 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.17599869 152.12199402 Tm [(quant)1(u)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.33100128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.83100128 152.12199402 Tm [(yie)-1(ld\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.41999817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.91999817 152.12199402 Tm [(Ty)-1(p)1(ic)-1(ally,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.19400024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.69400024 152.12199402 Tm [(ye)-1(llow)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.18200684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.68200684 152.12199402 Tm [(FPs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.13600159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.63600159 152.12199402 Tm [(serve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.17599487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.67599487 152.12199402 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.81700134 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.31700134 152.12199402 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 167.72200012 Tm [(acc)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.51499939 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.01499939 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.29299927 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.79299927 167.72200012 Tm [(gene)-1(t)1(ic)-1(a)1(l)-1(ly-enc)-1(o)1(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.49899292 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.99899292 167.72200012 Tm [(FRET)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.76300049 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.26300049 167.72200012 Tm [(sensors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.57200623 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.07200623 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.91400146 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.41400146 167.72200012 Tm [(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(hich)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.99099922 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.49099922 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.49200058 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.99200058 183.32200623 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.66600037 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.16600037 183.32200623 Tm [(lik)-1(ely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.1210022 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 183.32200623 Tm [(do)1(n)-1(o)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.80400085 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30400085 183.32200623 Tm [(FP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.59199524 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.09199524 183.32200623 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.65299988 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.15299988 183.32200623 Tm [(mCFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.89399719 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.39399719 183.32200623 Tm [(\(monomeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.70599365 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.20599365 183.32200623 Tm [(cy)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.05000305 0.75 m 166.05000305 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>