%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 113 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.53500366 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 163.29899597 23.67700005 Tm 0 Tr [(eC)-1(FP)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.32499695 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.76501465 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(eCFP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.8219986 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.32200623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.57200623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(e)1(CF)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.80500031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.17900085 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.95100403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.32499695 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.64599609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.02000427 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81599426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(eCFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.0719986 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(eCFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.0719986 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 173.92500305 78.75 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cyan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.80500031 11.72200012 Tm [(Flu)-1(o)1(re)-1(s)1(c)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.47599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.97599792 11.72200012 Tm [(Pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.04100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.54100037 11.72200012 Tm [(\(CFP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.86099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.36099243 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.92199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.42199707 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.39700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.89700317 11.72200012 Tm [(versat)1(il)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.05400085 11.72200012 Tm [(biolo)1(gic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 27.3220005 Tm [(marker)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.1570015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.6570015 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.93500137 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.43500137 27.3220005 Tm [(monito)1(rin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.73999786 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.23999786 27.3220005 Tm [(ph)1(y)-1(sio)1(l)-1(o)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.727005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.227005 27.3220005 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.52400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.02400208 27.3220005 Tm [(vis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ualizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.43399811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.93399811 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.24099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.74099731 42.92200089 Tm [(localizat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.71800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.21800232 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.49499512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.99499512 42.92200089 Tm [(detecting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.88200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.38200378 42.92200089 Tm [(tr)1(ansgeni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.17500305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.95399857 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.45399857 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.39500046 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.89500046 58.52199936 Tm [(vivo.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.62599945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.12599945 58.52199936 Tm [(CFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.43399811 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.93399811 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.96800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.46800232 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.32200623 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.82200623 58.52199936 Tm [(exc)-1(it)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.61399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.11399841 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.62600708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.12600708 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.1269989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.6269989 58.52199936 Tm [(40)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.46000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.96000671 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.43299961 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.93299961 74.12200165 Tm [(laser)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.01200104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.51200104 74.12200165 Tm [(line)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.95399857 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.45399857 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.73100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.23100281 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.79199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.29199982 74.12200165 Tm [(op)1(timally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.47099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.97099304 74.12200165 Tm [(detected)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.022995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.522995 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.85099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.35099792 74.12200165 Tm [(48)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.18400574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.68400574 74.12200165 Tm [(nm.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.83000183 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(eCF)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.41500092 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.26200104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.76200104 11.72200012 Tm [(mCFP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.50299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.00299835 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.30999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.80999756 11.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.96400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.46400452 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.90499878 11.72200012 Tm [(HEK29)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.36099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.86099243 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.27099609 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cyan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.80500031 11.72200012 Tm [(Flu)-1(o)1(re)-1(s)1(c)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.47599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.97599792 11.72200012 Tm [(Pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.04100037 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.92500305 16.35000038 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(27)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 27.3220005 Tm [(Positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.59600067 27.3220005 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 47.54999924 l 173.92500305 47.54999924 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HEK29)-1(3T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61500168 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11500168 11.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.69100189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.19100189 11.72200012 Tm [(were)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.94599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.44599915 11.72200012 Tm [(tr)1(ansfec)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.87800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.37800598 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.77400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27400208 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.7749939 11.72200012 Tm [(pCMV6-ENT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(RY)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30700016 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 27.3220005 Tm [(control)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49399948 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.99399948 27.3220005 Tm [(\(Le)-1(f)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.19799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.69799805 27.3220005 Tm [(lane\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.72599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.22599792 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.38400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.88400269 27.3220005 Tm [(pCMV6-ENTRY)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.43499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.93499756 27.3220005 Tm [(eCF)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.3500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.8500061 27.3220005 Tm [(ne)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.50799561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.00799561 27.3220005 Tm [(cD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64900017 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.14900017 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.42700005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.92699814 42.92200089 Tm [(48)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.48300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.98300171 42.92200089 Tm [(hrs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.1269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.6269989 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.90399933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.40399933 42.92200089 Tm [(lyse)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.59200287 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 0.75 m 173.55000305 78.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 79.5 m 173.55000305 95.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 95.84999847 m 173.55000305 111.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 112.19999695 m 173.55000305 127.79999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 128.54998779 m 173.55000305 144.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 144.8999939 m 173.55000305 160.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 161.25 m 173.55000305 208.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 208.42500305 m 423.17498779 208.42500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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