%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 127 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.69100189 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 146.36700439 23.67700005 Tm 0 Tr [(6X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.63499451 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.60899353 23.67700005 Tm [(Hi)1(s)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 208.16799927 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 318.60800171 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(6X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.39700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.77100372 12.82499981 Tm [(Hi)-1(s)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 115.45400238 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.95399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.45399475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(6)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 89.05500031 12.82499981 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 99.55500031 12.82499981 Tm [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.61299896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.98699951 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.63699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.01100159 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.57000732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.94400024 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.74000549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.3219986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.69599915 12.82499981 Tm [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.7539978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.12799835 12.82499981 Tm [(epito)-1(pe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.0739975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.44799805 12.82499981 Tm [(tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.93699646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0014001500040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 105 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(6)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 68.3219986 12.82499981 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 78.8219986 12.82499981 Tm [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.87999725 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.91100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.28500366 12.82499981 Tm [(protein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.147995 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.98300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.35699463 12.82499981 Tm [(the)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.61500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.98899841 12.82499981 Tm [(HIS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.00100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.375 12.82499981 Tm [(Tag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.46400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700130026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAADB 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 166.42500305 0.75 l 166.42500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 167.42500305 -0.25 l 167.42500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.17500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 167.17500305 141.1499939 l h f* Q q 1 0 0 1 166.80000305 0 cm -0.625 -0.25 m 256.625 -0.25 l 256.625 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.58499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.08499908 11.72200012 Tm [(X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.88999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.38999939 11.72200012 Tm [(hist)1(idine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.54499817 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.56800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.06800079 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.1289978 11.72200012 Tm [(used)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.70399475 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.20399475 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.34500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.84500122 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.82000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.32000732 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.40400696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.90400696 11.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.17199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.67199707 11.72200012 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.38900757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.88900757 11.72200012 Tm [(rec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(omb)1(i)-1(na)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.71699905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.21699905 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.69000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.19000244 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.26499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.76499939 27.3220005 Tm [(fa)1(c)-1(ilitat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.34500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.84500122 27.3220005 Tm [(purificat)1(ion.It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.15400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.65400696 27.3220005 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.68800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.18800354 27.3220005 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.73500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.85400009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35400009 42.92200089 Tm [(purified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.85800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.35800171 42.92200089 Tm [(using)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.76799774 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.26799774 42.92200089 Tm [(immobilized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.4730072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.9730072 42.92200089 Tm [(metal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.23500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.73500061 42.92200089 Tm [(ions,t)1(rad)1(i)-1(t)1(ionally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.19000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nic)-1(ke)-1(l,)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.96300125 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.46300125 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.43799973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.93799973 58.52199936 Tm [(pro)1(c)-1(edure)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.30999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.80999756 58.52199936 Tm [(termed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.0019989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.5019989 58.52199936 Tm [(immobilized-)1(me)-1(t)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.86199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36199951 58.52199936 Tm [(af)1(fini)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 74.12200165 Tm [(chromat)1(og)1(raph)1(y)-1(.)1(F)-1(urt)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.54799652 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.04799652 74.12200165 Tm [(analysis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.42900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.92900085 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.77099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.27099609 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.27200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.77200317 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.07899475 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.57899475 74.12200165 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.61300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.85400009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35400009 89.72200012 Tm [(achieve)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.47200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.97200012 89.72200012 Tm [(using)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.38200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.88200378 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.40299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.90299988 89.72200012 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.16200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.66200256 89.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.6190033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.1190033 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.19400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.69400024 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.69500732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.19500732 89.72200012 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.4730072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.9730072 89.72200012 Tm [(X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.77799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.27799988 89.72200012 Tm [(hist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(idine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.1989994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.6989994 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.63999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.13999939 105.3219986 Tm [(technique)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.16999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.66999817 105.3219986 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.43699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.93699646 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.07800293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.57800293 105.3219986 Tm [(west)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.397995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.897995 105.3219986 Tm [(blot)1(ting.)1(T)-1(h)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.13999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.63999939 105.3219986 Tm [(antib)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(od)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.24200058 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.74200058 120.92199707 Tm [(rec)-1(o)1(gnizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.91500092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.41500092 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.41600037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.91600037 120.92199707 Tm [(Hi)-1(s)1(-ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.41600037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.91600037 120.92199707 Tm [(fused)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.61099243 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.11099243 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.18600464 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.68600464 120.92199707 Tm [(ta)1(rgeted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.52999878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.02999878 120.92199707 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.50300598 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 136.52200317 Tm [(tr)1(ansfec)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.8730011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.3730011 136.52200317 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.53099823 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.03099823 136.52200317 Tm [(tr)1(ansfor)1(m)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.08200073 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.58200073 136.52200317 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.32400513 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 166.42500305 0.75 l 166.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.42500305 -0.25 l 167.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.17500305 16.35000038 l h f* Q q 1 0 0 1 166.80000305 0 cm -0.625 -0.25 m 256.625 -0.25 l 256.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 166.42500305 0.75 l 166.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.42500305 -0.25 l 167.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.17500305 16.35000038 l h f* Q q 1 0 0 1 166.80000305 0 cm -0.625 -0.25 m 256.625 -0.25 l 256.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 11.72200012 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.95300007 11.72200012 Tm [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.47500038 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.80000305 0.75 m 166.80000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.80000305 141.8999939 m 166.80000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.80000305 158.25 m 166.80000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>